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The hypoglycemic effects of American red ginseng (Panax quinquefolius L.) on a diabetic mouse model.
J Food Sci 2012; 77(7):H147-52JF

Abstract

American ginseng (Panax quinquefolius L.) root health benefits include treatment of type 2 diabetes and this study evaluated the hypoglycemic effects of American red ginseng (ARG). ARG roots have increased bioactive phenolic contents, such as cinnamic acid and ferulic acid during the steaming process. The antihyperglycemic effects of methanol fraction extract of ARG, ferulic acid, and cinnamic acid were examined using a type 2 diabetic mouse model. The ARG treated group presented relatively lower blood glucose levels than the control group (P < 0.05). In addition, the glycogen and high density lipoprotein (HDL) contents were significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL) concentration were significantly decreased in the ARG treated group. The groups treated with ferulic and cinnamic acids showed similar effects as those found in the ARG treated group. Thus, it is suggested that ARG roots, ferulic acid, and cinnamic acid have hypoglycemic effects in an animal model.

PRACTICAL APPLICATION

This study was conducted to elucidate the hypoglycemic effects of American red ginseng (ARG) using a type 2 diabetic mouse model. ARG showed an enhanced antioxidant capacity and higher antihyperglycemia effect. The glycogen and high density lipoprotein (HDL) contents were significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL) concentration were significantly decreased in the ARG treated group. It is suggested that ARG has a potential to be used for human diabetic treatment.

Authors+Show Affiliations

Dept of Food and Nutrition, SoongEui Women's College, Seoul 100-751, South Korea. bkmoon@cau.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22757707

Citation

Yoo, Kyung Mi, et al. "The Hypoglycemic Effects of American Red Ginseng (Panax Quinquefolius L.) On a Diabetic Mouse Model." Journal of Food Science, vol. 77, no. 7, 2012, pp. H147-52.
Yoo KM, Lee C, Lo YM, et al. The hypoglycemic effects of American red ginseng (Panax quinquefolius L.) on a diabetic mouse model. J Food Sci. 2012;77(7):H147-52.
Yoo, K. M., Lee, C., Lo, Y. M., & Moon, B. (2012). The hypoglycemic effects of American red ginseng (Panax quinquefolius L.) on a diabetic mouse model. Journal of Food Science, 77(7), pp. H147-52. doi:10.1111/j.1750-3841.2012.02748.x.
Yoo KM, et al. The Hypoglycemic Effects of American Red Ginseng (Panax Quinquefolius L.) On a Diabetic Mouse Model. J Food Sci. 2012;77(7):H147-52. PubMed PMID: 22757707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The hypoglycemic effects of American red ginseng (Panax quinquefolius L.) on a diabetic mouse model. AU - Yoo,Kyung Mi, AU - Lee,Cy, AU - Lo,Y Martin, AU - Moon,BoKyung, PY - 2012/7/5/entrez PY - 2012/7/5/pubmed PY - 2012/11/10/medline SP - H147 EP - 52 JF - Journal of food science JO - J. Food Sci. VL - 77 IS - 7 N2 - UNLABELLED: American ginseng (Panax quinquefolius L.) root health benefits include treatment of type 2 diabetes and this study evaluated the hypoglycemic effects of American red ginseng (ARG). ARG roots have increased bioactive phenolic contents, such as cinnamic acid and ferulic acid during the steaming process. The antihyperglycemic effects of methanol fraction extract of ARG, ferulic acid, and cinnamic acid were examined using a type 2 diabetic mouse model. The ARG treated group presented relatively lower blood glucose levels than the control group (P < 0.05). In addition, the glycogen and high density lipoprotein (HDL) contents were significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL) concentration were significantly decreased in the ARG treated group. The groups treated with ferulic and cinnamic acids showed similar effects as those found in the ARG treated group. Thus, it is suggested that ARG roots, ferulic acid, and cinnamic acid have hypoglycemic effects in an animal model. PRACTICAL APPLICATION: This study was conducted to elucidate the hypoglycemic effects of American red ginseng (ARG) using a type 2 diabetic mouse model. ARG showed an enhanced antioxidant capacity and higher antihyperglycemia effect. The glycogen and high density lipoprotein (HDL) contents were significantly increased while levels of plasma cholesterol and low density lipoprotein (LDL) concentration were significantly decreased in the ARG treated group. It is suggested that ARG has a potential to be used for human diabetic treatment. SN - 1750-3841 UR - https://www.unboundmedicine.com/medline/citation/22757707/The_hypoglycemic_effects_of_American_red_ginseng__Panax_quinquefolius_L___on_a_diabetic_mouse_model_ L2 - https://doi.org/10.1111/j.1750-3841.2012.02748.x DB - PRIME DP - Unbound Medicine ER -