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25-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study.
BMC Nephrol. 2012 Jul 03; 13:55.BN

Abstract

BACKGROUND

Low 25-hydroxy vitamin D (25(OH)D) levels have been associated with an increased risk of albuminuria, however an association with glomerular filtration rate (GFR) is not clear. We explored the relationship between 25(OH)D levels and prevalent chronic kidney disease (CKD), albuminuria and impaired GFR, in a national, population-based cohort of Australian adults (AusDiab Study).

METHODS

10,732 adults ≥ 25 years of age participating in the baseline survey of the AusDiab study (1999-2000) were included. The GFR was estimated using an enzymatic creatinine assay and the CKD-EPI equation, with CKD defined as eGFR <60 ml/min/1.73 m(2). Albuminuria was defined as a spot urine albumin to creatinine ratio (ACR) of ≥ 2.5 mg/mmol for men and ≥ 3.5 for women. Serum 25(OH)D levels of <50 nmol/L were considered vitamin D deficient. The associations between 25(OH)D level, albuminuria and impaired eGFR were estimated using multivariate regression models.

RESULTS

30.7% of the study population had a 25(OH)D level <50 nmol/L (95% CI 25.6-35.8). 25(OH)D deficiency was significantly associated with an impaired eGFR in the univariate model (OR 1.52, 95% CI 1.07-2.17), but not in the multivariate model (OR 0.95, 95% CI 0.67-1.35). 25(OH)D deficiency was significantly associated with albuminuria in the univariate (OR 2.05, 95% CI 1.58-2.67) and multivariate models (OR 1.54, 95% CI 1.14-2.07).

CONCLUSIONS

Vitamin D deficiency is common in this population, and 25(OH)D levels of <50 nmol/L were independently associated with albuminuria, but not with impaired eGFR. These associations warrant further exploration in prospective and interventional studies.

Authors+Show Affiliations

Department of Nephrology, Monash Medical Centre, 246 Clayton Road, Clayton, 3168, Victoria, Australia. matthew.damasiewicz@monash.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22759247

Citation

Damasiewicz, Matthew J., et al. "25-Hydroxyvitamin D Levels and Chronic Kidney Disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) Study." BMC Nephrology, vol. 13, 2012, p. 55.
Damasiewicz MJ, Magliano DJ, Daly RM, et al. 25-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study. BMC Nephrol. 2012;13:55.
Damasiewicz, M. J., Magliano, D. J., Daly, R. M., Gagnon, C., Lu, Z. X., Ebeling, P. R., Chadban, S. J., Atkins, R. C., Kerr, P. G., Shaw, J. E., & Polkinghorne, K. R. (2012). 25-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study. BMC Nephrology, 13, 55. https://doi.org/10.1186/1471-2369-13-55
Damasiewicz MJ, et al. 25-Hydroxyvitamin D Levels and Chronic Kidney Disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) Study. BMC Nephrol. 2012 Jul 3;13:55. PubMed PMID: 22759247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 25-Hydroxyvitamin D levels and chronic kidney disease in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study. AU - Damasiewicz,Matthew J, AU - Magliano,Dianna J, AU - Daly,Robin M, AU - Gagnon,Claudia, AU - Lu,Zhong X, AU - Ebeling,Peter R, AU - Chadban,Steven J, AU - Atkins,Robert C, AU - Kerr,Peter G, AU - Shaw,Jonathan E, AU - Polkinghorne,Kevan R, Y1 - 2012/07/03/ PY - 2012/05/02/received PY - 2012/06/21/accepted PY - 2012/7/5/entrez PY - 2012/7/5/pubmed PY - 2013/5/28/medline SP - 55 EP - 55 JF - BMC nephrology JO - BMC Nephrol VL - 13 N2 - BACKGROUND: Low 25-hydroxy vitamin D (25(OH)D) levels have been associated with an increased risk of albuminuria, however an association with glomerular filtration rate (GFR) is not clear. We explored the relationship between 25(OH)D levels and prevalent chronic kidney disease (CKD), albuminuria and impaired GFR, in a national, population-based cohort of Australian adults (AusDiab Study). METHODS: 10,732 adults ≥ 25 years of age participating in the baseline survey of the AusDiab study (1999-2000) were included. The GFR was estimated using an enzymatic creatinine assay and the CKD-EPI equation, with CKD defined as eGFR <60 ml/min/1.73 m(2). Albuminuria was defined as a spot urine albumin to creatinine ratio (ACR) of ≥ 2.5 mg/mmol for men and ≥ 3.5 for women. Serum 25(OH)D levels of <50 nmol/L were considered vitamin D deficient. The associations between 25(OH)D level, albuminuria and impaired eGFR were estimated using multivariate regression models. RESULTS: 30.7% of the study population had a 25(OH)D level <50 nmol/L (95% CI 25.6-35.8). 25(OH)D deficiency was significantly associated with an impaired eGFR in the univariate model (OR 1.52, 95% CI 1.07-2.17), but not in the multivariate model (OR 0.95, 95% CI 0.67-1.35). 25(OH)D deficiency was significantly associated with albuminuria in the univariate (OR 2.05, 95% CI 1.58-2.67) and multivariate models (OR 1.54, 95% CI 1.14-2.07). CONCLUSIONS: Vitamin D deficiency is common in this population, and 25(OH)D levels of <50 nmol/L were independently associated with albuminuria, but not with impaired eGFR. These associations warrant further exploration in prospective and interventional studies. SN - 1471-2369 UR - https://www.unboundmedicine.com/medline/citation/22759247/25_Hydroxyvitamin_D_levels_and_chronic_kidney_disease_in_the_AusDiab__Australian_Diabetes_Obesity_and_Lifestyle__study_ L2 - https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-13-55 DB - PRIME DP - Unbound Medicine ER -