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Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies.
Am J Clin Nutr. 2012 Aug; 96(2):356-73.AJ

Abstract

BACKGROUND

Measurement errors in the dietary assessment of fruit and vegetable intake may attenuate associations with breast cancer risk and might explain the weak associations observed in epidemiologic studies. Carotenoid concentrations in blood are biomarkers of fruit and vegetable intake; however, no systematic assessment has compared dietary intake with blood concentrations of carotenoids and breast cancer risk.

OBJECTIVE

We conducted a systematic review and meta-analysis of prospective studies of dietary intake and blood concentrations of carotenoids and breast cancer risk.

DESIGN

We searched PubMed and several other databases for relevant studies up to 31 August 2011. Random-effects models were used to estimate summary estimates.

RESULTS

Of the 6 dietary carotenoids assessed, only intake of β-carotene was significantly associated with a reduced breast cancer risk (summary RR: 0.95; 95% CI: 0.91, 0.99; I(2): 0%) per 5000 μg/d (n = 10). In contrast, the summary RR for blood concentrations of carotenoids was 0.78 (95% CI: 0.61, 0.99; I(2): 53%) per 100 μg total carotenoids/dL (n = 7), 0.74 (95% CI: 0.57, 0.97; I(2): 43%) per 50 μg β-carotene/dL (n = 13), 0.82 (95% CI: 0.73, 0.92, I(2): 3%) per 10 μg α-carotene/dL (n = 12), and 0.68 (95% CI: 0.52, 0.89; I(2): 0%) per 25 μg lutein/dL (n = 6).

CONCLUSIONS

Blood concentrations of carotenoids are more strongly associated with reduced breast cancer risk than are carotenoids assessed by dietary questionnaires. Our results suggest that the use of certain biomarkers may clarify inconsistent and weak results between dietary intake and breast cancer risk.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom. d.aune@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

22760559

Citation

Aune, Dagfinn, et al. "Dietary Compared With Blood Concentrations of Carotenoids and Breast Cancer Risk: a Systematic Review and Meta-analysis of Prospective Studies." The American Journal of Clinical Nutrition, vol. 96, no. 2, 2012, pp. 356-73.
Aune D, Chan DS, Vieira AR, et al. Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr. 2012;96(2):356-73.
Aune, D., Chan, D. S., Vieira, A. R., Navarro Rosenblatt, D. A., Vieira, R., Greenwood, D. C., & Norat, T. (2012). Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies. The American Journal of Clinical Nutrition, 96(2), 356-73. https://doi.org/10.3945/ajcn.112.034165
Aune D, et al. Dietary Compared With Blood Concentrations of Carotenoids and Breast Cancer Risk: a Systematic Review and Meta-analysis of Prospective Studies. Am J Clin Nutr. 2012;96(2):356-73. PubMed PMID: 22760559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies. AU - Aune,Dagfinn, AU - Chan,Doris S M, AU - Vieira,Ana Rita, AU - Navarro Rosenblatt,Deborah A, AU - Vieira,Rui, AU - Greenwood,Darren C, AU - Norat,Teresa, Y1 - 2012/07/03/ PY - 2012/7/5/entrez PY - 2012/7/5/pubmed PY - 2012/10/2/medline SP - 356 EP - 73 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 96 IS - 2 N2 - BACKGROUND: Measurement errors in the dietary assessment of fruit and vegetable intake may attenuate associations with breast cancer risk and might explain the weak associations observed in epidemiologic studies. Carotenoid concentrations in blood are biomarkers of fruit and vegetable intake; however, no systematic assessment has compared dietary intake with blood concentrations of carotenoids and breast cancer risk. OBJECTIVE: We conducted a systematic review and meta-analysis of prospective studies of dietary intake and blood concentrations of carotenoids and breast cancer risk. DESIGN: We searched PubMed and several other databases for relevant studies up to 31 August 2011. Random-effects models were used to estimate summary estimates. RESULTS: Of the 6 dietary carotenoids assessed, only intake of β-carotene was significantly associated with a reduced breast cancer risk (summary RR: 0.95; 95% CI: 0.91, 0.99; I(2): 0%) per 5000 μg/d (n = 10). In contrast, the summary RR for blood concentrations of carotenoids was 0.78 (95% CI: 0.61, 0.99; I(2): 53%) per 100 μg total carotenoids/dL (n = 7), 0.74 (95% CI: 0.57, 0.97; I(2): 43%) per 50 μg β-carotene/dL (n = 13), 0.82 (95% CI: 0.73, 0.92, I(2): 3%) per 10 μg α-carotene/dL (n = 12), and 0.68 (95% CI: 0.52, 0.89; I(2): 0%) per 25 μg lutein/dL (n = 6). CONCLUSIONS: Blood concentrations of carotenoids are more strongly associated with reduced breast cancer risk than are carotenoids assessed by dietary questionnaires. Our results suggest that the use of certain biomarkers may clarify inconsistent and weak results between dietary intake and breast cancer risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22760559/Dietary_compared_with_blood_concentrations_of_carotenoids_and_breast_cancer_risk:_a_systematic_review_and_meta_analysis_of_prospective_studies_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.034165 DB - PRIME DP - Unbound Medicine ER -