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The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study.

Abstract

BACKGROUND

Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products.

OBJECTIVE

The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups.

DESIGN

A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis.

RESULTS

Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles.

CONCLUSIONS

This large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined fermented dairy product intake with diabetes is suggested, which merits further study.

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  • Authors+Show Affiliations

    ,

    University Medical Center Utrecht, Netherlands.

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    Source

    MeSH

    Adult
    Cohort Studies
    Dairy Products
    Diabetes Mellitus, Type 2
    Diet
    Energy Intake
    Europe
    Female
    Follow-Up Studies
    Humans
    Incidence
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22760573

    Citation

    Sluijs, Ivonne, et al. "The Amount and Type of Dairy Product Intake and Incident Type 2 Diabetes: Results From the EPIC-InterAct Study." The American Journal of Clinical Nutrition, vol. 96, no. 2, 2012, pp. 382-90.
    Sluijs I, Forouhi NG, Beulens JW, et al. The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study. Am J Clin Nutr. 2012;96(2):382-90.
    Sluijs, I., Forouhi, N. G., Beulens, J. W., van der Schouw, Y. T., Agnoli, C., Arriola, L., ... Wareham, N. J. (2012). The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study. The American Journal of Clinical Nutrition, 96(2), pp. 382-90.
    Sluijs I, et al. The Amount and Type of Dairy Product Intake and Incident Type 2 Diabetes: Results From the EPIC-InterAct Study. Am J Clin Nutr. 2012;96(2):382-90. PubMed PMID: 22760573.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study. AU - Sluijs,Ivonne, AU - Forouhi,Nita G, AU - Beulens,Joline W J, AU - van der Schouw,Yvonne T, AU - Agnoli,Claudia, AU - Arriola,Larraitz, AU - Balkau,Beverley, AU - Barricarte,Aurelio, AU - Boeing,Heiner, AU - Bueno-de-Mesquita,H Bas, AU - Clavel-Chapelon,Françoise, AU - Crowe,Francesca L, AU - de Lauzon-Guillain,Blandine, AU - Drogan,Dagmar, AU - Franks,Paul W, AU - Gavrila,Diana, AU - Gonzalez,Carlos, AU - Halkjaer,Jytte, AU - Kaaks,Rudolf, AU - Moskal,Aurelie, AU - Nilsson,Peter, AU - Overvad,Kim, AU - Palli,Domenico, AU - Panico,Salvatore, AU - Quirós,José R, AU - Ricceri,Fulvio, AU - Rinaldi,Sabina, AU - Rolandsson,Olov, AU - Sacerdote,Carlotta, AU - Sánchez,María-José, AU - Slimani,Nadia, AU - Spijkerman,Annemieke M W, AU - Teucher,Birgit, AU - Tjonneland,Anne, AU - Tormo,María-José, AU - Tumino,Rosario, AU - van der A,Daphne L, AU - Sharp,Stephen J, AU - Langenberg,Claudia, AU - Feskens,Edith J M, AU - Riboli,Elio, AU - Wareham,Nicholas J, AU - ,, Y1 - 2012/07/03/ PY - 2012/7/5/entrez PY - 2012/7/5/pubmed PY - 2012/10/2/medline SP - 382 EP - 90 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 2 N2 - BACKGROUND: Dairy product intake may be inversely associated with risk of type 2 diabetes, but the evidence is inconclusive for total dairy products and sparse for types of dairy products. OBJECTIVE: The objective was to investigate the prospective association of total dairy products and different dairy subtypes with incidence of diabetes in populations with marked variation of intake of these food groups. DESIGN: A nested case-cohort within 8 European countries of the European Prospective Investigation into Cancer and Nutrition Study (n = 340,234; 3.99 million person-years of follow-up) included a random subcohort (n = 16,835) and incident diabetes cases (n = 12,403). Baseline dairy product intake was assessed by using dietary questionnaires. Country-specific Prentice-weighted Cox regression HRs were calculated and pooled by using a random-effects meta-analysis. RESULTS: Intake of total dairy products was not associated with diabetes (HR for the comparison of the highest with the lowest quintile of total dairy products: 1.01; 95% CI: 0.83, 1.34; P-trend = 0.92) in an analysis adjusted for age, sex, BMI, diabetes risk factors, education, and dietary factors. Of the dairy subtypes, cheese intake tended to have an inverse association with diabetes (HR: 0.88; 95% CI: 0.76, 1.02; P-trend = 0.01), and a higher combined intake of fermented dairy products (cheese, yogurt, and thick fermented milk) was inversely associated with diabetes (HR: 0.88; 95% CI: 0.78, 0.99; P-trend = 0.02) in adjusted analyses that compared extreme quintiles. CONCLUSIONS: This large prospective study found no association between total dairy product intake and diabetes risk. An inverse association of cheese intake and combined fermented dairy product intake with diabetes is suggested, which merits further study. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22760573/The_amount_and_type_of_dairy_product_intake_and_incident_type_2_diabetes:_results_from_the_EPIC_InterAct_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.021907 DB - PRIME DP - Unbound Medicine ER -