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The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability.
Mol Nutr Food Res. 2012 Jul; 56(7):1073-80.MN

Abstract

Atherosclerosis has an important inflammatory component and acute cardiovascular events can be initiated by inflammatory processes occurring in advanced plaques. Fatty acids influence inflammation through a variety of mechanisms; many of these are mediated by, or associated with, the fatty acid composition of cell membranes. Human inflammatory cells are typically rich in the n-6 fatty acid arachidonic acid, but the contents of arachidonic acid and of the marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can be altered through oral administration of EPA and DHA. Eicosanoids produced from arachidonic acid have roles in inflammation. EPA also gives rise to eicosanoids and these are usually biologically weak. EPA and DHA give rise to resolvins which are anti-inflammatory and inflammation resolving. EPA and DHA also affect production of peptide mediators of inflammation (adhesion molecules, cytokines, etc.). Thus, the fatty acid composition of human inflammatory cells influences their function; the contents of arachidonic acid, EPA and DHA appear to be especially important. The anti-inflammatory effects of marine n-3 polyunsaturated fatty acids (PUFAs) may contribute to their protective actions towards atherosclerosis and plaque rupture.

Authors+Show Affiliations

Faculty of Medicine, University of Southampton, MP887 Southampton General Hospital, Southampton, UK. pcc@soton.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22760980

Citation

Calder, Philip C.. "The Role of Marine Omega-3 (n-3) Fatty Acids in Inflammatory Processes, Atherosclerosis and Plaque Stability." Molecular Nutrition & Food Research, vol. 56, no. 7, 2012, pp. 1073-80.
Calder PC. The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability. Mol Nutr Food Res. 2012;56(7):1073-80.
Calder, P. C. (2012). The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability. Molecular Nutrition & Food Research, 56(7), 1073-80. https://doi.org/10.1002/mnfr.201100710
Calder PC. The Role of Marine Omega-3 (n-3) Fatty Acids in Inflammatory Processes, Atherosclerosis and Plaque Stability. Mol Nutr Food Res. 2012;56(7):1073-80. PubMed PMID: 22760980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability. A1 - Calder,Philip C, PY - 2012/7/5/entrez PY - 2012/7/5/pubmed PY - 2012/10/30/medline SP - 1073 EP - 80 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 56 IS - 7 N2 - Atherosclerosis has an important inflammatory component and acute cardiovascular events can be initiated by inflammatory processes occurring in advanced plaques. Fatty acids influence inflammation through a variety of mechanisms; many of these are mediated by, or associated with, the fatty acid composition of cell membranes. Human inflammatory cells are typically rich in the n-6 fatty acid arachidonic acid, but the contents of arachidonic acid and of the marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can be altered through oral administration of EPA and DHA. Eicosanoids produced from arachidonic acid have roles in inflammation. EPA also gives rise to eicosanoids and these are usually biologically weak. EPA and DHA give rise to resolvins which are anti-inflammatory and inflammation resolving. EPA and DHA also affect production of peptide mediators of inflammation (adhesion molecules, cytokines, etc.). Thus, the fatty acid composition of human inflammatory cells influences their function; the contents of arachidonic acid, EPA and DHA appear to be especially important. The anti-inflammatory effects of marine n-3 polyunsaturated fatty acids (PUFAs) may contribute to their protective actions towards atherosclerosis and plaque rupture. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/22760980/The_role_of_marine_omega_3__n_3__fatty_acids_in_inflammatory_processes_atherosclerosis_and_plaque_stability_ L2 - https://doi.org/10.1002/mnfr.201100710 DB - PRIME DP - Unbound Medicine ER -