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Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC).
PLoS One. 2012; 7(6):e39361.Plos

Abstract

BACKGROUND

Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location.

METHODOLOGY/PRINCIPAL FINDINGS

After a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79-0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals.

CONCLUSIONS/SIGNIFICANCE

Our results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22761771

Citation

Murphy, Neil, et al. "Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation Into Cancer and Nutrition (EPIC)." PloS One, vol. 7, no. 6, 2012, pp. e39361.
Murphy N, Norat T, Ferrari P, et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS One. 2012;7(6):e39361.
Murphy, N., Norat, T., Ferrari, P., Jenab, M., Bueno-de-Mesquita, B., Skeie, G., Dahm, C. C., Overvad, K., Olsen, A., Tjønneland, A., Clavel-Chapelon, F., Boutron-Ruault, M. C., Racine, A., Kaaks, R., Teucher, B., Boeing, H., Bergmann, M. M., Trichopoulou, A., Trichopoulos, D., ... Riboli, E. (2012). Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PloS One, 7(6), e39361. https://doi.org/10.1371/journal.pone.0039361
Murphy N, et al. Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation Into Cancer and Nutrition (EPIC). PLoS One. 2012;7(6):e39361. PubMed PMID: 22761771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). AU - Murphy,Neil, AU - Norat,Teresa, AU - Ferrari,Pietro, AU - Jenab,Mazda, AU - Bueno-de-Mesquita,Bas, AU - Skeie,Guri, AU - Dahm,Christina C, AU - Overvad,Kim, AU - Olsen,Anja, AU - Tjønneland,Anne, AU - Clavel-Chapelon,Françoise, AU - Boutron-Ruault,Marie Christine, AU - Racine,Antoine, AU - Kaaks,Rudolf, AU - Teucher,Birgit, AU - Boeing,Heiner, AU - Bergmann,Manuela M, AU - Trichopoulou,Antonia, AU - Trichopoulos,Dimitrios, AU - Lagiou,Pagona, AU - Palli,Domenico, AU - Pala,Valeria, AU - Panico,Salvatore, AU - Tumino,Rosario, AU - Vineis,Paolo, AU - Siersema,Peter, AU - van Duijnhoven,Franzel, AU - Peeters,Petra H M, AU - Hjartaker,Anette, AU - Engeset,Dagrun, AU - González,Carlos A, AU - Sánchez,Maria-José, AU - Dorronsoro,Miren, AU - Navarro,Carmen, AU - Ardanaz,Eva, AU - Quirós,José R, AU - Sonestedt,Emily, AU - Ericson,Ulrika, AU - Nilsson,Lena, AU - Palmqvist,Richard, AU - Khaw,Kay-Tee, AU - Wareham,Nick, AU - Key,Timothy J, AU - Crowe,Francesca L, AU - Fedirko,Veronika, AU - Wark,Petra A, AU - Chuang,Shu-Chun, AU - Riboli,Elio, Y1 - 2012/06/22/ PY - 2012/01/23/received PY - 2012/05/18/accepted PY - 2012/7/5/entrez PY - 2012/7/5/pubmed PY - 2013/3/22/medline SP - e39361 EP - e39361 JF - PloS one JO - PLoS One VL - 7 IS - 6 N2 - BACKGROUND: Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. METHODOLOGY/PRINCIPAL FINDINGS: After a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79-0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals. CONCLUSIONS/SIGNIFICANCE: Our results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22761771/Dietary_fibre_intake_and_risks_of_cancers_of_the_colon_and_rectum_in_the_European_prospective_investigation_into_cancer_and_nutrition__EPIC__ L2 - https://dx.plos.org/10.1371/journal.pone.0039361 DB - PRIME DP - Unbound Medicine ER -