Tags

Type your tag names separated by a space and hit enter

Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children.
Nutr Metab Cardiovasc Dis. 2013 Aug; 23(8):785-91.NM

Abstract

BACKGROUND AND AIM

Evidence of the relationship between serum vitamin D levels and cardiovascular risk factors in children is limited. We investigated the associations between serum vitamin D levels (25-hydroxyvitamin D [25(OH)D]) and obesity and metabolic syndrome and its components in Korean children.

METHODS AND RESULTS

We recruited 1660, nine-year-old, Korean children (904 boys and 756 girls) who voluntarily participated in this study while being examined during school-based health examinations. We measured anthropometric variables (height and weight), metabolic parameters (blood pressure, fasting plasma glucose, triglyceride, and HDL cholesterol levels) and serum vitamin D levels. We analyzed the data using multivariate logistic regression models. Mean 25(OH)D levels were lower in children defined as obese or abdominally obese (P <0.001). When serum levels of 25(OH)D were divided into quartiles, BMI, waist circumference, and triglyceride levels were lower, and HDL cholesterol levels were higher, as vitamin D levels increased. Using children from the highest quartile of 25(OH)D levels as a referent, the adjusted ORs (95% CI) for obesity in those in the third, second, and lowest quartiles of 25(OH)D levels were 1.55 (1.01-2.40), 1.87 (1.22-2.85), and 2.59 (1.71-3.90), respectively (P for trend <0.001). For abdominal obesity the ORs (CI) were 2.08 (1.20-3.60), 2.32 (1.36-3.95), and 2.96 (1.75-5.00) (P for trend<0.001), and for metabolic syndrome they were 2.60 (1.08-6.30), 4.00 (1.73-9.26), and 4.25 (1.84-9.85), respectively (P for trend <0.05).

CONCLUSIONS

We found low vitamin D levels in Korean children to be associated with obesity and metabolic syndrome. Insufficient serum vitamin D levels in children may be a risk factor of obesity and metabolic syndrome.

Authors+Show Affiliations

Department of Family Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22762845

Citation

Lee, S H., et al. "Serum 25-hydroxyvitamin D Levels, Obesity and the Metabolic Syndrome Among Korean Children." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 23, no. 8, 2013, pp. 785-91.
Lee SH, Kim SM, Park HS, et al. Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children. Nutr Metab Cardiovasc Dis. 2013;23(8):785-91.
Lee, S. H., Kim, S. M., Park, H. S., Choi, K. M., Cho, G. J., Ko, B. J., & Kim, J. H. (2013). Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 23(8), 785-91. https://doi.org/10.1016/j.numecd.2012.04.013
Lee SH, et al. Serum 25-hydroxyvitamin D Levels, Obesity and the Metabolic Syndrome Among Korean Children. Nutr Metab Cardiovasc Dis. 2013;23(8):785-91. PubMed PMID: 22762845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children. AU - Lee,S H, AU - Kim,S M, AU - Park,H S, AU - Choi,K M, AU - Cho,G J, AU - Ko,B J, AU - Kim,J H, Y1 - 2012/07/03/ PY - 2011/12/20/received PY - 2012/04/02/revised PY - 2012/04/25/accepted PY - 2012/7/6/entrez PY - 2012/7/6/pubmed PY - 2014/2/6/medline KW - 25(OH)D KW - 25-hydroxyvitamin D KW - ATP III KW - BMI KW - HDL KW - KMOSES KW - LDL KW - MetS KW - Metabolic syndrome KW - NCEP KW - National Cholesterol Education Program KW - Obesity KW - The Korean Metabolic Disorders and Obesity Study in Elementary School Children KW - Vitamin D KW - adult treatment panel III KW - body mass index KW - high density lipoprotein KW - low density lipoprotein KW - metabolic syndrome SP - 785 EP - 91 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 23 IS - 8 N2 - BACKGROUND AND AIM: Evidence of the relationship between serum vitamin D levels and cardiovascular risk factors in children is limited. We investigated the associations between serum vitamin D levels (25-hydroxyvitamin D [25(OH)D]) and obesity and metabolic syndrome and its components in Korean children. METHODS AND RESULTS: We recruited 1660, nine-year-old, Korean children (904 boys and 756 girls) who voluntarily participated in this study while being examined during school-based health examinations. We measured anthropometric variables (height and weight), metabolic parameters (blood pressure, fasting plasma glucose, triglyceride, and HDL cholesterol levels) and serum vitamin D levels. We analyzed the data using multivariate logistic regression models. Mean 25(OH)D levels were lower in children defined as obese or abdominally obese (P <0.001). When serum levels of 25(OH)D were divided into quartiles, BMI, waist circumference, and triglyceride levels were lower, and HDL cholesterol levels were higher, as vitamin D levels increased. Using children from the highest quartile of 25(OH)D levels as a referent, the adjusted ORs (95% CI) for obesity in those in the third, second, and lowest quartiles of 25(OH)D levels were 1.55 (1.01-2.40), 1.87 (1.22-2.85), and 2.59 (1.71-3.90), respectively (P for trend <0.001). For abdominal obesity the ORs (CI) were 2.08 (1.20-3.60), 2.32 (1.36-3.95), and 2.96 (1.75-5.00) (P for trend<0.001), and for metabolic syndrome they were 2.60 (1.08-6.30), 4.00 (1.73-9.26), and 4.25 (1.84-9.85), respectively (P for trend <0.05). CONCLUSIONS: We found low vitamin D levels in Korean children to be associated with obesity and metabolic syndrome. Insufficient serum vitamin D levels in children may be a risk factor of obesity and metabolic syndrome. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/22762845/Serum_25_hydroxyvitamin_D_levels_obesity_and_the_metabolic_syndrome_among_Korean_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(12)00123-8 DB - PRIME DP - Unbound Medicine ER -