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What should we recommend to our patients with NAFLD regarding alcohol use?
Am J Gastroenterol 2012; 107(7):976-8AJ

Abstract

It is generally recommended that patients with nonalcoholic fatty liver disease (NAFLD) not consume alcohol. However, because these patients are at increased cardiovascular risk, and light to moderate alcohol consumption may have hepatic benefits in people with or at risk for NAFLD, this recommendation may be ill-advised. We reviewed the literature on alcohol consumption and NAFLD and conclude that (i) heavy consumption has many harmful effects, including those on the liver, and should be discouraged whether a person has NAFLD or not; (ii) it is unknown whether cardiovascular and metabolic benefits of light to moderate consumption observed in the general population extend to those with NAFLD; (iii) epidemiological and cohort studies suggesting that light to moderate drinking may have hepatic benefits are largely cross-sectional and used surrogate end points; and (iv) until further data from rigorous prospective studies become available, people with NAFLD should avoid alcohol of any type or amount.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

22764020

Citation

Liangpunsakul, Suthat, and Naga Chalasani. "What Should We Recommend to Our Patients With NAFLD Regarding Alcohol Use?" The American Journal of Gastroenterology, vol. 107, no. 7, 2012, pp. 976-8.
Liangpunsakul S, Chalasani N. What should we recommend to our patients with NAFLD regarding alcohol use? Am J Gastroenterol. 2012;107(7):976-8.
Liangpunsakul, S., & Chalasani, N. (2012). What should we recommend to our patients with NAFLD regarding alcohol use? The American Journal of Gastroenterology, 107(7), pp. 976-8. doi:10.1038/ajg.2012.20.
Liangpunsakul S, Chalasani N. What Should We Recommend to Our Patients With NAFLD Regarding Alcohol Use. Am J Gastroenterol. 2012;107(7):976-8. PubMed PMID: 22764020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - What should we recommend to our patients with NAFLD regarding alcohol use? AU - Liangpunsakul,Suthat, AU - Chalasani,Naga, PY - 2012/7/6/entrez PY - 2012/7/6/pubmed PY - 2012/10/25/medline SP - 976 EP - 8 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 107 IS - 7 N2 - It is generally recommended that patients with nonalcoholic fatty liver disease (NAFLD) not consume alcohol. However, because these patients are at increased cardiovascular risk, and light to moderate alcohol consumption may have hepatic benefits in people with or at risk for NAFLD, this recommendation may be ill-advised. We reviewed the literature on alcohol consumption and NAFLD and conclude that (i) heavy consumption has many harmful effects, including those on the liver, and should be discouraged whether a person has NAFLD or not; (ii) it is unknown whether cardiovascular and metabolic benefits of light to moderate consumption observed in the general population extend to those with NAFLD; (iii) epidemiological and cohort studies suggesting that light to moderate drinking may have hepatic benefits are largely cross-sectional and used surrogate end points; and (iv) until further data from rigorous prospective studies become available, people with NAFLD should avoid alcohol of any type or amount. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/22764020/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=22764020 DB - PRIME DP - Unbound Medicine ER -