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[Effect of electroacupuncture stimulation of auricular concha region at different time-points on behavior changes in depression rats].
Zhen Ci Yan Jiu. 2012 Apr; 37(2):131-5.ZC

Abstract

OBJECTIVE To observe the effect of electroacupuncture (EA) stimulation of auricular concha region (ACR) on behavior changes of depression rats.

METHODS

A total of 80 male Wistar rats were randomized into depression model (model, n = 6), EA-ACR (n = 12), preventive EA-ACR (Pre-EA-ACR, n = 11) and EA-ear-tip (n = 12) groups. Depression model was established by chronic unpredictable mild stress for 21 days and isolated breeding. Open-field test and sucrose solution intake preference test were conducted to assess changes of the rats' behavior activities before modeling and on day 22, 36 and 50 after starting model. For rats of the pre-EA-ACR group, EA (2 Hz, 1 mA) was applied to the bilateral auricular concha area for 20 min, once daily for 14 days, beginning from the 8th day on after starting model preparation till the end of the modeling, and for rats of the EA-ACR and EA-ear-tip groups, EA was given to the bilateral ACR and ear-tips respectively, beginning after modeling, once daily for 14 days.

RESULTS

In comparison with pre-modeling, the percentages of sucrose solution consumption in rats of the model group decreased gradually from day 22 to 50 (P > 0.05). Compared with the model group,the percentage of sucrose solution consumption in the EA-ACR group was increased significantly on day 50 (P < 0.05), suggesting an inhibitory effect of EA on the reduction of sucrose intake preference at this time-point. No significant differences were found between the pre-EA-ACR and the model groups and between the EA-ear-tip and model groups as well as between the EA-ACR and model groups at most time-points (P > 0.05). Open-field test showed that in comparison with pre-modeling in the same one group, the total scores, crossing and rearing scores on day 22 were decreased considerably in the model and EA-ear-tip groups (P < 0.05, P < 0.01), rather than in the pre-EA-ACR and EA-ARC groups (P > 0.05), suggesting a suppressing effect of pre-EA-ACR and EA-ACR on depression behavior. Compared to day 22 in the same one group, the total scores, crossing and rearing scores on day 36 and 50 in the pre-EA-ACR and EA-ear-tip groups were decreased significantly (P < 0.05, P < 0.01).

CONCLUSION

EA of auricular concha region can restrain the development of depression behavioral status in depression rats, which is superior to that of EA of ear-tip.

Authors+Show Affiliations

Institute of Acu-moxibustion, China Acadmy of Chinese Medical Sciences, Beijing 100700, China. Acupeng@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

22764599

Citation

Liu, Ru-Peng, et al. "[Effect of Electroacupuncture Stimulation of Auricular Concha Region at Different Time-points On Behavior Changes in Depression Rats]." Zhen Ci Yan Jiu = Acupuncture Research, vol. 37, no. 2, 2012, pp. 131-5.
Liu RP, Rong PJ, Huang ZX, et al. [Effect of electroacupuncture stimulation of auricular concha region at different time-points on behavior changes in depression rats]. Zhen Ci Yan Jiu. 2012;37(2):131-5.
Liu, R. P., Rong, P. J., Huang, Z. X., Ben, H., Li, L., Ma, H. M., Ma, Y. G., & Zhu, B. (2012). [Effect of electroacupuncture stimulation of auricular concha region at different time-points on behavior changes in depression rats]. Zhen Ci Yan Jiu = Acupuncture Research, 37(2), 131-5.
Liu RP, et al. [Effect of Electroacupuncture Stimulation of Auricular Concha Region at Different Time-points On Behavior Changes in Depression Rats]. Zhen Ci Yan Jiu. 2012;37(2):131-5. PubMed PMID: 22764599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of electroacupuncture stimulation of auricular concha region at different time-points on behavior changes in depression rats]. AU - Liu,Ru-Peng, AU - Rong,Pei-Jing, AU - Huang,Zhan-Xia, AU - Ben,Hui, AU - Li,Liang, AU - Ma,Hui-Min, AU - Ma,Ying-Ge, AU - Zhu,Bing, PY - 2012/7/7/entrez PY - 2012/7/7/pubmed PY - 2012/8/29/medline SP - 131 EP - 5 JF - Zhen ci yan jiu = Acupuncture research JO - Zhen Ci Yan Jiu VL - 37 IS - 2 N2 - UNLABELLED: OBJECTIVE To observe the effect of electroacupuncture (EA) stimulation of auricular concha region (ACR) on behavior changes of depression rats. METHODS: A total of 80 male Wistar rats were randomized into depression model (model, n = 6), EA-ACR (n = 12), preventive EA-ACR (Pre-EA-ACR, n = 11) and EA-ear-tip (n = 12) groups. Depression model was established by chronic unpredictable mild stress for 21 days and isolated breeding. Open-field test and sucrose solution intake preference test were conducted to assess changes of the rats' behavior activities before modeling and on day 22, 36 and 50 after starting model. For rats of the pre-EA-ACR group, EA (2 Hz, 1 mA) was applied to the bilateral auricular concha area for 20 min, once daily for 14 days, beginning from the 8th day on after starting model preparation till the end of the modeling, and for rats of the EA-ACR and EA-ear-tip groups, EA was given to the bilateral ACR and ear-tips respectively, beginning after modeling, once daily for 14 days. RESULTS: In comparison with pre-modeling, the percentages of sucrose solution consumption in rats of the model group decreased gradually from day 22 to 50 (P > 0.05). Compared with the model group,the percentage of sucrose solution consumption in the EA-ACR group was increased significantly on day 50 (P < 0.05), suggesting an inhibitory effect of EA on the reduction of sucrose intake preference at this time-point. No significant differences were found between the pre-EA-ACR and the model groups and between the EA-ear-tip and model groups as well as between the EA-ACR and model groups at most time-points (P > 0.05). Open-field test showed that in comparison with pre-modeling in the same one group, the total scores, crossing and rearing scores on day 22 were decreased considerably in the model and EA-ear-tip groups (P < 0.05, P < 0.01), rather than in the pre-EA-ACR and EA-ARC groups (P > 0.05), suggesting a suppressing effect of pre-EA-ACR and EA-ACR on depression behavior. Compared to day 22 in the same one group, the total scores, crossing and rearing scores on day 36 and 50 in the pre-EA-ACR and EA-ear-tip groups were decreased significantly (P < 0.05, P < 0.01). CONCLUSION: EA of auricular concha region can restrain the development of depression behavioral status in depression rats, which is superior to that of EA of ear-tip. SN - 1000-0607 UR - https://www.unboundmedicine.com/medline/citation/22764599/[Effect_of_electroacupuncture_stimulation_of_auricular_concha_region_at_different_time_points_on_behavior_changes_in_depression_rats]_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -