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Vitamin D and multiple sclerosis: a critical review and recommendations on treatment.

Abstract

Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neurology, University of California, San Francisco, USA.

    , , ,

    Source

    Acta neurologica Belgica 112:4 2012 Dec pg 327-33

    MeSH

    Adult
    Humans
    Multiple Sclerosis
    Vitamin D
    Vitamin D Deficiency
    Vitamins

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    22767049

    Citation

    Faridar, Alireza, et al. "Vitamin D and Multiple Sclerosis: a Critical Review and Recommendations On Treatment." Acta Neurologica Belgica, vol. 112, no. 4, 2012, pp. 327-33.
    Faridar A, Eskandari G, Sahraian MA, et al. Vitamin D and multiple sclerosis: a critical review and recommendations on treatment. Acta Neurol Belg. 2012;112(4):327-33.
    Faridar, A., Eskandari, G., Sahraian, M. A., Minagar, A., & Azimi, A. (2012). Vitamin D and multiple sclerosis: a critical review and recommendations on treatment. Acta Neurologica Belgica, 112(4), pp. 327-33. doi:10.1007/s13760-012-0108-z.
    Faridar A, et al. Vitamin D and Multiple Sclerosis: a Critical Review and Recommendations On Treatment. Acta Neurol Belg. 2012;112(4):327-33. PubMed PMID: 22767049.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D and multiple sclerosis: a critical review and recommendations on treatment. AU - Faridar,Alireza, AU - Eskandari,Ghazaleh, AU - Sahraian,Mohammad Ali, AU - Minagar,Alireza, AU - Azimi,Amirreza, Y1 - 2012/07/06/ PY - 2012/05/18/received PY - 2012/06/19/accepted PY - 2012/7/7/entrez PY - 2012/7/7/pubmed PY - 2013/9/17/medline SP - 327 EP - 33 JF - Acta neurologica Belgica JO - Acta Neurol Belg VL - 112 IS - 4 N2 - Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients. SN - 2240-2993 UR - https://www.unboundmedicine.com/medline/citation/22767049/Vitamin_D_and_multiple_sclerosis:_a_critical_review_and_recommendations_on_treatment_ L2 - https://dx.doi.org/10.1007/s13760-012-0108-z DB - PRIME DP - Unbound Medicine ER -