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Vitamin D and multiple sclerosis: a critical review and recommendations on treatment.
Acta Neurol Belg 2012; 112(4):327-33AN

Abstract

Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients.

Authors+Show Affiliations

Department of Neurology, University of California, San Francisco, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22767049

Citation

Faridar, Alireza, et al. "Vitamin D and Multiple Sclerosis: a Critical Review and Recommendations On Treatment." Acta Neurologica Belgica, vol. 112, no. 4, 2012, pp. 327-33.
Faridar A, Eskandari G, Sahraian MA, et al. Vitamin D and multiple sclerosis: a critical review and recommendations on treatment. Acta Neurol Belg. 2012;112(4):327-33.
Faridar, A., Eskandari, G., Sahraian, M. A., Minagar, A., & Azimi, A. (2012). Vitamin D and multiple sclerosis: a critical review and recommendations on treatment. Acta Neurologica Belgica, 112(4), pp. 327-33. doi:10.1007/s13760-012-0108-z.
Faridar A, et al. Vitamin D and Multiple Sclerosis: a Critical Review and Recommendations On Treatment. Acta Neurol Belg. 2012;112(4):327-33. PubMed PMID: 22767049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and multiple sclerosis: a critical review and recommendations on treatment. AU - Faridar,Alireza, AU - Eskandari,Ghazaleh, AU - Sahraian,Mohammad Ali, AU - Minagar,Alireza, AU - Azimi,Amirreza, Y1 - 2012/07/06/ PY - 2012/05/18/received PY - 2012/06/19/accepted PY - 2012/7/7/entrez PY - 2012/7/7/pubmed PY - 2013/9/17/medline SP - 327 EP - 33 JF - Acta neurologica Belgica JO - Acta Neurol Belg VL - 112 IS - 4 N2 - Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients. SN - 2240-2993 UR - https://www.unboundmedicine.com/medline/citation/22767049/Vitamin_D_and_multiple_sclerosis:_a_critical_review_and_recommendations_on_treatment_ DB - PRIME DP - Unbound Medicine ER -