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Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4).

Abstract

BACKGROUND

Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction.

PATIENTS AND METHODS

A pooled analysis of a history of pancreatitis and risk of pancreatic cancer was carried out considering the time interval between diagnoses and potential modification by covariates. Adjusted pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from 10 case-control studies (5048 cases of ductal pancreatic adenocarcinoma and 10,947 controls) taking part in the International Pancreatic Cancer Case-Control Consortium (PanC4).

RESULTS

The association between pancreatitis and pancreatic cancer was nearly three-fold at intervals of >2 years between diagnoses (OR: 2.71, 95% CI: 1.96-3.74) and much stronger at intervals of ≤2 years (OR: 13.56, 95% CI: 8.72-21.90) probably reflecting a combination of reverse causation and antecedent misdiagnosis of pancreas cancer as pancreatitis. The younger (<65 years) pancreatic cancer cases showed stronger associations with previous (>2 years) pancreatitis (OR: 3.91, 95% CI: 2.53-6.04) than the older (≥65 years) cases (OR: 1.68, 95% CI: 1.02-2.76; P value for interaction: 0.006).

CONCLUSIONS

Despite a moderately strong association between pancreatitis (diagnosed before >2 years) and pancreatic cancer, the population attributable fraction was estimated at 1.34% (95% CI: 0.612-2.07%), suggesting that a relatively small proportion of pancreatic cancer might be avoided if pancreatitis could be prevented.

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  • Authors+Show Affiliations

    ,

    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. eduell@iconcologia.net

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    Source

    MeSH

    Adenocarcinoma
    Aged
    Alcohol Drinking
    Case-Control Studies
    Diabetes Complications
    Female
    Humans
    Male
    Middle Aged
    Odds Ratio
    Pancreatic Neoplasms
    Pancreatitis
    Risk Factors
    Smoking

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, N.I.H., Intramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    22767586

    Citation

    Duell, E J., et al. "Pancreatitis and Pancreatic Cancer Risk: a Pooled Analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 11, 2012, pp. 2964-70.
    Duell EJ, Lucenteforte E, Olson SH, et al. Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol. 2012;23(11):2964-70.
    Duell, E. J., Lucenteforte, E., Olson, S. H., Bracci, P. M., Li, D., Risch, H. A., ... Boffetta, P. (2012). Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(11), pp. 2964-70. doi:10.1093/annonc/mds140.
    Duell EJ, et al. Pancreatitis and Pancreatic Cancer Risk: a Pooled Analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Ann Oncol. 2012;23(11):2964-70. PubMed PMID: 22767586.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). AU - Duell,E J, AU - Lucenteforte,E, AU - Olson,S H, AU - Bracci,P M, AU - Li,D, AU - Risch,H A, AU - Silverman,D T, AU - Ji,B T, AU - Gallinger,S, AU - Holly,E A, AU - Fontham,E H, AU - Maisonneuve,P, AU - Bueno-de-Mesquita,H B, AU - Ghadirian,P, AU - Kurtz,R C, AU - Ludwig,E, AU - Yu,H, AU - Lowenfels,A B, AU - Seminara,D, AU - Petersen,G M, AU - La Vecchia,C, AU - Boffetta,P, Y1 - 2012/07/05/ PY - 2012/7/7/entrez PY - 2012/7/7/pubmed PY - 2013/4/30/medline SP - 2964 EP - 70 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 11 N2 - BACKGROUND: Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction. PATIENTS AND METHODS: A pooled analysis of a history of pancreatitis and risk of pancreatic cancer was carried out considering the time interval between diagnoses and potential modification by covariates. Adjusted pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from 10 case-control studies (5048 cases of ductal pancreatic adenocarcinoma and 10,947 controls) taking part in the International Pancreatic Cancer Case-Control Consortium (PanC4). RESULTS: The association between pancreatitis and pancreatic cancer was nearly three-fold at intervals of >2 years between diagnoses (OR: 2.71, 95% CI: 1.96-3.74) and much stronger at intervals of ≤2 years (OR: 13.56, 95% CI: 8.72-21.90) probably reflecting a combination of reverse causation and antecedent misdiagnosis of pancreas cancer as pancreatitis. The younger (<65 years) pancreatic cancer cases showed stronger associations with previous (>2 years) pancreatitis (OR: 3.91, 95% CI: 2.53-6.04) than the older (≥65 years) cases (OR: 1.68, 95% CI: 1.02-2.76; P value for interaction: 0.006). CONCLUSIONS: Despite a moderately strong association between pancreatitis (diagnosed before >2 years) and pancreatic cancer, the population attributable fraction was estimated at 1.34% (95% CI: 0.612-2.07%), suggesting that a relatively small proportion of pancreatic cancer might be avoided if pancreatitis could be prevented. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/22767586/Pancreatitis_and_pancreatic_cancer_risk:_a_pooled_analysis_in_the_International_Pancreatic_Cancer_Case_Control_Consortium__PanC4__ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mds140 DB - PRIME DP - Unbound Medicine ER -