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Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis.
Cancer Epidemiol. 2012 Dec; 36(6):e373-9.CE

Abstract

INTRODUCTION

NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2), involved in detoxification of environmental carcinogens and activation of chemotherapeutic agents, are supposed to play critical role in carcinogenesis. So, we aimed to investigate the association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer (EC) in north Indian population. We also performed Meta analysis of published literatures on NQO1 609C>T polymorphism to systematically evaluate its association with EC.

METHODS

We genotyped NQO1 609C>T and NQO2 -3423G>A polymorphisms in 200 incident EC cases (including 150 follow-up cases) and 200 controls using PCR RFLP based methods. Binary logistic regression was applied for risk estimation, while Kaplan Meier and Cox regression tests were applied for survival analysis. All Meta analysis tests were performed using MIX 2.0 software.

RESULTS

The present study did not find any significant association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility to EC or its clinical phenotypes (histopathology, tumor location or lymph node metastasis) or interactions with lifestyle risk factors (tobacco usage, smoking, alcohol habit and occupational exposures). Meta analysis of NQO1 polymorphism also indicated null association of the polymorphism with EC overall or with cancer cases stratified by tumor histopathology/ethnicity. Moreover, no prognostic implication of both polymorphisms was observed in EC.

CONCLUSION

NQO1 609C>T and NQO2 -3423G>A polymorphisms do not seem to play any significant role in susceptibility or prognosis of EC in north Indian population and results of Meta-analysis further reinforces null association of NQO1 609C>T polymorphism with EC susceptibility.

Authors+Show Affiliations

Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22770696

Citation

Umar, Meenakshi, et al. "Null Association of NQO1 609C>T and NQO2 -3423G>A Polymorphisms With Susceptibility and Prognosis of Esophageal Cancer in North Indian Population and Meta-analysis." Cancer Epidemiology, vol. 36, no. 6, 2012, pp. e373-9.
Umar M, Upadhyay R, Kumar S, et al. Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis. Cancer Epidemiol. 2012;36(6):e373-9.
Umar, M., Upadhyay, R., Kumar, S., Ghoshal, U. C., & Mittal, B. (2012). Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis. Cancer Epidemiology, 36(6), e373-9. https://doi.org/10.1016/j.canep.2012.06.004
Umar M, et al. Null Association of NQO1 609C>T and NQO2 -3423G>A Polymorphisms With Susceptibility and Prognosis of Esophageal Cancer in North Indian Population and Meta-analysis. Cancer Epidemiol. 2012;36(6):e373-9. PubMed PMID: 22770696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis. AU - Umar,Meenakshi, AU - Upadhyay,Rohit, AU - Kumar,Shaleen, AU - Ghoshal,Uday Chand, AU - Mittal,Balraj, Y1 - 2012/07/06/ PY - 2012/03/12/received PY - 2012/06/10/revised PY - 2012/06/13/accepted PY - 2012/7/10/entrez PY - 2012/7/10/pubmed PY - 2013/7/3/medline SP - e373 EP - 9 JF - Cancer epidemiology JO - Cancer Epidemiol VL - 36 IS - 6 N2 - INTRODUCTION: NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2), involved in detoxification of environmental carcinogens and activation of chemotherapeutic agents, are supposed to play critical role in carcinogenesis. So, we aimed to investigate the association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer (EC) in north Indian population. We also performed Meta analysis of published literatures on NQO1 609C>T polymorphism to systematically evaluate its association with EC. METHODS: We genotyped NQO1 609C>T and NQO2 -3423G>A polymorphisms in 200 incident EC cases (including 150 follow-up cases) and 200 controls using PCR RFLP based methods. Binary logistic regression was applied for risk estimation, while Kaplan Meier and Cox regression tests were applied for survival analysis. All Meta analysis tests were performed using MIX 2.0 software. RESULTS: The present study did not find any significant association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility to EC or its clinical phenotypes (histopathology, tumor location or lymph node metastasis) or interactions with lifestyle risk factors (tobacco usage, smoking, alcohol habit and occupational exposures). Meta analysis of NQO1 polymorphism also indicated null association of the polymorphism with EC overall or with cancer cases stratified by tumor histopathology/ethnicity. Moreover, no prognostic implication of both polymorphisms was observed in EC. CONCLUSION: NQO1 609C>T and NQO2 -3423G>A polymorphisms do not seem to play any significant role in susceptibility or prognosis of EC in north Indian population and results of Meta-analysis further reinforces null association of NQO1 609C>T polymorphism with EC susceptibility. SN - 1877-783X UR - https://www.unboundmedicine.com/medline/citation/22770696/Null_association_of_NQO1_609C>T_and_NQO2__3423G>A_polymorphisms_with_susceptibility_and_prognosis_of_Esophageal_cancer_in_north_Indian_population_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1877-7821(12)00087-2 DB - PRIME DP - Unbound Medicine ER -