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Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency.
Diabetes Res Clin Pract 2012; 97(3):359-67DR

Abstract

Metformin treatment is a known pharmacological cause of vitamin B12 (Cbl) deficiency with controversial responsible mechanisms. A possible diagnosis of this deficiency is based mainly on the combination of patient's medical history (usually long-term metformin use), clinical examination (possible neuropsychiatric symptoms and signs), laboratory studies which confirm a Cbl deficiency (haematological abnormalities, low serum Cbl levels, elevated serum total homocysteine and methylmalonic acid levels), and exclusion other causes of Cbl deficiency (as pernicious anaemia, food-cobalamin malabsorption syndrome, other drugs, etc.). In our review, recommendations for diagnosis and management of metformin-induced Cbl deficiency (MICD) in diabetic patients based on medical bibliography are presented and discussed.

Authors+Show Affiliations

Department of Internal Medicine, Naval Hospital of Crete, 73 200 Chania, Crete, Greece. emazokopakis@yahoo.grNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22770998

Citation

Mazokopakis, Elias E., and Ioannis K. Starakis. "Recommendations for Diagnosis and Management of Metformin-induced Vitamin B12 (Cbl) Deficiency." Diabetes Research and Clinical Practice, vol. 97, no. 3, 2012, pp. 359-67.
Mazokopakis EE, Starakis IK. Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency. Diabetes Res Clin Pract. 2012;97(3):359-67.
Mazokopakis, E. E., & Starakis, I. K. (2012). Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency. Diabetes Research and Clinical Practice, 97(3), pp. 359-67. doi:10.1016/j.diabres.2012.06.001.
Mazokopakis EE, Starakis IK. Recommendations for Diagnosis and Management of Metformin-induced Vitamin B12 (Cbl) Deficiency. Diabetes Res Clin Pract. 2012;97(3):359-67. PubMed PMID: 22770998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency. AU - Mazokopakis,Elias E, AU - Starakis,Ioannis K, Y1 - 2012/07/07/ PY - 2012/02/27/received PY - 2012/05/17/revised PY - 2012/06/12/accepted PY - 2012/7/10/entrez PY - 2012/7/10/pubmed PY - 2013/2/26/medline SP - 359 EP - 67 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 97 IS - 3 N2 - Metformin treatment is a known pharmacological cause of vitamin B12 (Cbl) deficiency with controversial responsible mechanisms. A possible diagnosis of this deficiency is based mainly on the combination of patient's medical history (usually long-term metformin use), clinical examination (possible neuropsychiatric symptoms and signs), laboratory studies which confirm a Cbl deficiency (haematological abnormalities, low serum Cbl levels, elevated serum total homocysteine and methylmalonic acid levels), and exclusion other causes of Cbl deficiency (as pernicious anaemia, food-cobalamin malabsorption syndrome, other drugs, etc.). In our review, recommendations for diagnosis and management of metformin-induced Cbl deficiency (MICD) in diabetic patients based on medical bibliography are presented and discussed. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/22770998/Recommendations_for_diagnosis_and_management_of_metformin_induced_vitamin_B12__Cbl__deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(12)00216-1 DB - PRIME DP - Unbound Medicine ER -