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Antiulcerogenic effect of Croton urucurana Baillon bark.
J Ethnopharmacol. 2012 Aug 30; 143(1):331-7.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Croton urucurana (Euphorbiaceae) bark is used to treat gastric ulcers. However, to our knowledge, no study has been conducted to confirm this therapeutic property.

AIM OF THE STUDY

To evaluate the antiulcerogenic effect and any possible toxic effects of Croton urucurana bark in an induced gastric ulcer model in rats.

MATERIALS AND METHODS

The preventive and healing properties of Croton urucurana bark methanol extract (CUE) were evaluated in experimental models of acute (ethanol and indomethacin) and chronic (acetic acid) gastric ulcers. The gastric juice and mucous were evaluated using the pylorus ligation model, while the gastroprotective action of sulphydryl compounds and nitric oxide were analysed using the ethanol model. The toxicity was evaluated with acute and subacute toxicity tests.

RESULTS

No signs of toxicity were observed in the parameters analysed. All of the CUE doses tested (50, 100 and 250mg/kg) significantly reduced the gastric lesions by 70.25, 95.40 and 98.71%, respectively. Treatment with 30mg/kg lansoprazole (positive control) inhibited 82.58% of the gastric lesions. In the indomethacin model, the 50, 100 and 250mg/kg doses of CUE significantly reduced gastric damage by 67.85, 82.50 and 71.01%, respectively, and the positive control, cimetidine (200mg/kg), reduced gastric damage by 91.02%. The CUE (100mg/kg) and cimetidine (200mg/kg) treatments significantly reduced the ulcerative pathology induced by acetic acid, promoting 81.55 and 72.62% healing, respectively. Nitric oxide did not change the cytoprotection generated by CUE. However, the antiulcerogenic activity of CUE appears to involve sulphydryl compounds because CUE activity was inhibited in animals receiving a sulphydryl compound blocker. In addition, CUE exhibited systemic effects, increasing mucous production and decreasing gastric acidity.

CONCLUSIONS

The present study shows that Croton urucurana bark exerts gastroprotective activity in rats without causing toxicity. This effect appears to involve sulphydryl compounds, increasing mucus production and reducing gastric acidity.

Authors+Show Affiliations

Federal University of Grande Dourados, College of Health Science, Dourados, Mato Grosso do Sul CEP 79804-970, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22771279

Citation

Wolff Cordeiro, Kátia, et al. "Antiulcerogenic Effect of Croton Urucurana Baillon Bark." Journal of Ethnopharmacology, vol. 143, no. 1, 2012, pp. 331-7.
Wolff Cordeiro K, Aparecida Pinto L, Nazari Formagio AS, et al. Antiulcerogenic effect of Croton urucurana Baillon bark. J Ethnopharmacol. 2012;143(1):331-7.
Wolff Cordeiro, K., Aparecida Pinto, L., Nazari Formagio, A. S., Faloni de Andrade, S., Leite Kassuya, C. A., & de Cássia Freitas, K. (2012). Antiulcerogenic effect of Croton urucurana Baillon bark. Journal of Ethnopharmacology, 143(1), 331-7. https://doi.org/10.1016/j.jep.2012.06.044
Wolff Cordeiro K, et al. Antiulcerogenic Effect of Croton Urucurana Baillon Bark. J Ethnopharmacol. 2012 Aug 30;143(1):331-7. PubMed PMID: 22771279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiulcerogenic effect of Croton urucurana Baillon bark. AU - Wolff Cordeiro,Kátia, AU - Aparecida Pinto,Lorraine, AU - Nazari Formagio,Anelise Samara, AU - Faloni de Andrade,Sérgio, AU - Leite Kassuya,Cândida Aparecida, AU - de Cássia Freitas,Karine, Y1 - 2012/07/04/ PY - 2012/02/22/received PY - 2012/06/21/revised PY - 2012/06/25/accepted PY - 2012/7/10/entrez PY - 2012/7/10/pubmed PY - 2012/12/19/medline SP - 331 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 143 IS - 1 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Croton urucurana (Euphorbiaceae) bark is used to treat gastric ulcers. However, to our knowledge, no study has been conducted to confirm this therapeutic property. AIM OF THE STUDY: To evaluate the antiulcerogenic effect and any possible toxic effects of Croton urucurana bark in an induced gastric ulcer model in rats. MATERIALS AND METHODS: The preventive and healing properties of Croton urucurana bark methanol extract (CUE) were evaluated in experimental models of acute (ethanol and indomethacin) and chronic (acetic acid) gastric ulcers. The gastric juice and mucous were evaluated using the pylorus ligation model, while the gastroprotective action of sulphydryl compounds and nitric oxide were analysed using the ethanol model. The toxicity was evaluated with acute and subacute toxicity tests. RESULTS: No signs of toxicity were observed in the parameters analysed. All of the CUE doses tested (50, 100 and 250mg/kg) significantly reduced the gastric lesions by 70.25, 95.40 and 98.71%, respectively. Treatment with 30mg/kg lansoprazole (positive control) inhibited 82.58% of the gastric lesions. In the indomethacin model, the 50, 100 and 250mg/kg doses of CUE significantly reduced gastric damage by 67.85, 82.50 and 71.01%, respectively, and the positive control, cimetidine (200mg/kg), reduced gastric damage by 91.02%. The CUE (100mg/kg) and cimetidine (200mg/kg) treatments significantly reduced the ulcerative pathology induced by acetic acid, promoting 81.55 and 72.62% healing, respectively. Nitric oxide did not change the cytoprotection generated by CUE. However, the antiulcerogenic activity of CUE appears to involve sulphydryl compounds because CUE activity was inhibited in animals receiving a sulphydryl compound blocker. In addition, CUE exhibited systemic effects, increasing mucous production and decreasing gastric acidity. CONCLUSIONS: The present study shows that Croton urucurana bark exerts gastroprotective activity in rats without causing toxicity. This effect appears to involve sulphydryl compounds, increasing mucus production and reducing gastric acidity. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22771279/Antiulcerogenic_effect_of_Croton_urucurana_Baillon_bark_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00444-8 DB - PRIME DP - Unbound Medicine ER -