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The Parkinson's disease-related genes act in mitochondrial homeostasis.
Neurosci Biobehav Rev. 2012 Oct; 36(9):2034-43.NB

Abstract

Neurons are metabolically active cells with high energy demands. Thus, neurons are particularly reliant on mitochondrial function, especially on the homeostasis properties of mitochondria. This is reflected by the observation that mitochondrial abnormalities have been well recognized to contribute to neurodegenerative diseases, like Parkinson's disease (PD). Mitochondria are highly complex and dynamic organelles continuously undergoing different alterations. The dynamic property of mitochondria is named as mitochondrial homeostasis. Imbalance of mitochondrial homeostasis is associated with neurodegenerative disease, such as Parkinson's diseases. Recently, the related genes of PD-familial, such as alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, are observed to be associated with mitochondria, and capable of modulating normal mitochondrial integrity and functions under certain conditions. Therefore, in this review, we will focus on the action of PD-related genes in mitochondrial homeostasis.

Authors+Show Affiliations

The Institute of Toxicology, Third Military Medical University, Chongqing 400038, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22771336

Citation

Sai, Yan, et al. "The Parkinson's Disease-related Genes Act in Mitochondrial Homeostasis." Neuroscience and Biobehavioral Reviews, vol. 36, no. 9, 2012, pp. 2034-43.
Sai Y, Zou Z, Peng K, et al. The Parkinson's disease-related genes act in mitochondrial homeostasis. Neurosci Biobehav Rev. 2012;36(9):2034-43.
Sai, Y., Zou, Z., Peng, K., & Dong, Z. (2012). The Parkinson's disease-related genes act in mitochondrial homeostasis. Neuroscience and Biobehavioral Reviews, 36(9), 2034-43. https://doi.org/10.1016/j.neubiorev.2012.06.007
Sai Y, et al. The Parkinson's Disease-related Genes Act in Mitochondrial Homeostasis. Neurosci Biobehav Rev. 2012;36(9):2034-43. PubMed PMID: 22771336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Parkinson's disease-related genes act in mitochondrial homeostasis. AU - Sai,Yan, AU - Zou,Zhongmin, AU - Peng,Kaige, AU - Dong,Zhaojun, Y1 - 2012/07/06/ PY - 2012/02/21/received PY - 2012/05/09/revised PY - 2012/06/12/accepted PY - 2012/7/10/entrez PY - 2012/7/10/pubmed PY - 2013/3/15/medline SP - 2034 EP - 43 JF - Neuroscience and biobehavioral reviews JO - Neurosci Biobehav Rev VL - 36 IS - 9 N2 - Neurons are metabolically active cells with high energy demands. Thus, neurons are particularly reliant on mitochondrial function, especially on the homeostasis properties of mitochondria. This is reflected by the observation that mitochondrial abnormalities have been well recognized to contribute to neurodegenerative diseases, like Parkinson's disease (PD). Mitochondria are highly complex and dynamic organelles continuously undergoing different alterations. The dynamic property of mitochondria is named as mitochondrial homeostasis. Imbalance of mitochondrial homeostasis is associated with neurodegenerative disease, such as Parkinson's diseases. Recently, the related genes of PD-familial, such as alpha-synuclein, Parkin, PINK1, DJ-1 and LRRK2, are observed to be associated with mitochondria, and capable of modulating normal mitochondrial integrity and functions under certain conditions. Therefore, in this review, we will focus on the action of PD-related genes in mitochondrial homeostasis. SN - 1873-7528 UR - https://www.unboundmedicine.com/medline/citation/22771336/The_Parkinson's_disease_related_genes_act_in_mitochondrial_homeostasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0149-7634(12)00097-8 DB - PRIME DP - Unbound Medicine ER -