Tags

Type your tag names separated by a space and hit enter

Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behaviour.
Behav Pharmacol 2012; 23(5-6):551-9BP

Abstract

This study characterized the effects of seven diverse cannabinoid receptor agonists (and one antagonist) on ingestive behaviour in nondeprived adult, male CD1 mice. Microstructural analysis of licking for a range of concentrations of condensed milk (10, 15 and 20%) was carried out following administration of vehicle or: Δ⁹-tetrahydrocannabinol (Δ⁹-THC) at 1, 3 or 6 mg/kg; CP55,940 at 10, 30 or 50 µg/kg; Win 55,212-2 at 0.5, 1 or 3 mg/kg; HU-210 at 0.01, 0.03 or 0.1 mg/kg; methanandamide at 1, 3 or 6 mg/kg; arachidonyl-2'-chloroethylamide at 1, 3 or 6 mg/kg and JWH133 at 1, 3 or 6 mg/kg. The cannabinoid receptor antagonist/inverse agonist rimonabant was also tested at 0.3, 1 or 3 mg/kg. Test sessions comprised three 30 s presentations of the milk concentrations separated by 10 s interpresentation intervals. The nonselective CB1 receptor agonists Δ⁹-THC, CP55,940 and Win 55,212-2 increased the number of licks for condensed milk, primarily by a significant increase in bout number. The potent and nonselective CB1 receptor agonist HU-210 and the selective CB1 receptor agonists methanandamide and arachidonyl-2'-chloroethylamide did not significantly affect licking behaviour but did significantly increase the latency to start licking. The CB1 receptor antagonist rimonabant produced effects that were opposite in direction to those produced by Δ⁹-THC, CP55,940 and Win 55,212-2. Finally, the selective CB2 receptor agonist JWH133 had no significant effects on behaviour. These data add to reports that cannabinoid agonists can enhance the appetitive aspects of feeding, but they also demonstrate that not all CB1 receptor agonists do this, and therefore the relationship between action at CB1 receptors and appetitive feeding effects is not straightforward.

Authors+Show Affiliations

School of Psychology, University of Birmingham, Birmingham, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22772336

Citation

Grey, Jonathan, et al. "Contrasting Effects of Different Cannabinoid Receptor Ligands On Mouse Ingestive Behaviour." Behavioural Pharmacology, vol. 23, no. 5-6, 2012, pp. 551-9.
Grey J, Terry P, Higgs S. Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behaviour. Behav Pharmacol. 2012;23(5-6):551-9.
Grey, J., Terry, P., & Higgs, S. (2012). Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behaviour. Behavioural Pharmacology, 23(5-6), pp. 551-9. doi:10.1097/FBP.0b013e328356c3dc.
Grey J, Terry P, Higgs S. Contrasting Effects of Different Cannabinoid Receptor Ligands On Mouse Ingestive Behaviour. Behav Pharmacol. 2012;23(5-6):551-9. PubMed PMID: 22772336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behaviour. AU - Grey,Jonathan, AU - Terry,Phil, AU - Higgs,Suzanne, PY - 2012/7/10/entrez PY - 2012/7/10/pubmed PY - 2013/1/18/medline SP - 551 EP - 9 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 23 IS - 5-6 N2 - This study characterized the effects of seven diverse cannabinoid receptor agonists (and one antagonist) on ingestive behaviour in nondeprived adult, male CD1 mice. Microstructural analysis of licking for a range of concentrations of condensed milk (10, 15 and 20%) was carried out following administration of vehicle or: Δ⁹-tetrahydrocannabinol (Δ⁹-THC) at 1, 3 or 6 mg/kg; CP55,940 at 10, 30 or 50 µg/kg; Win 55,212-2 at 0.5, 1 or 3 mg/kg; HU-210 at 0.01, 0.03 or 0.1 mg/kg; methanandamide at 1, 3 or 6 mg/kg; arachidonyl-2'-chloroethylamide at 1, 3 or 6 mg/kg and JWH133 at 1, 3 or 6 mg/kg. The cannabinoid receptor antagonist/inverse agonist rimonabant was also tested at 0.3, 1 or 3 mg/kg. Test sessions comprised three 30 s presentations of the milk concentrations separated by 10 s interpresentation intervals. The nonselective CB1 receptor agonists Δ⁹-THC, CP55,940 and Win 55,212-2 increased the number of licks for condensed milk, primarily by a significant increase in bout number. The potent and nonselective CB1 receptor agonist HU-210 and the selective CB1 receptor agonists methanandamide and arachidonyl-2'-chloroethylamide did not significantly affect licking behaviour but did significantly increase the latency to start licking. The CB1 receptor antagonist rimonabant produced effects that were opposite in direction to those produced by Δ⁹-THC, CP55,940 and Win 55,212-2. Finally, the selective CB2 receptor agonist JWH133 had no significant effects on behaviour. These data add to reports that cannabinoid agonists can enhance the appetitive aspects of feeding, but they also demonstrate that not all CB1 receptor agonists do this, and therefore the relationship between action at CB1 receptors and appetitive feeding effects is not straightforward. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/22772336/abstract/Contrasting_effects_of_different_cannabinoid_receptor_ligands_on_mouse_ingestive_behaviour_ L2 - http://Insights.ovid.com/pubmed?pmid=22772336 DB - PRIME DP - Unbound Medicine ER -