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The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids.
Chem Commun (Camb). 2012 Aug 18; 48(64):8003-5.CC

Abstract

The first asymmetric aza-Friedel-Crafts reaction of indoles and pyrroles with isatin-derived N-Boc ketimines catalyzed by chiral phosphoric acids is reported. In general, derivatives of substituted 3-amino-2-oxindoles were obtained with excellent enantioselectivities and high yields.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Feng J
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
Yan W
No affiliation info available
Wang D
No affiliation info available
Li P
No affiliation info available
Sun Q
No affiliation info available
Wang R
No affiliation info available

MeSH

CatalysisIminesIndolesMolecular StructureNitrilesOxindolesPhosphoric AcidsPyrrolesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22773055

Citation

Feng, Jingchao, et al. "The Highly Enantioselective Addition of Indoles and Pyrroles to Isatins-derived N-Boc Ketimines Catalyzed By Chiral Phosphoric Acids." Chemical Communications (Cambridge, England), vol. 48, no. 64, 2012, pp. 8003-5.
Feng J, Yan W, Wang D, et al. The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids. Chem Commun (Camb). 2012;48(64):8003-5.
Feng, J., Yan, W., Wang, D., Li, P., Sun, Q., & Wang, R. (2012). The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids. Chemical Communications (Cambridge, England), 48(64), 8003-5. https://doi.org/10.1039/c2cc33200k
Feng J, et al. The Highly Enantioselective Addition of Indoles and Pyrroles to Isatins-derived N-Boc Ketimines Catalyzed By Chiral Phosphoric Acids. Chem Commun (Camb). 2012 Aug 18;48(64):8003-5. PubMed PMID: 22773055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The highly enantioselective addition of indoles and pyrroles to isatins-derived N-Boc ketimines catalyzed by chiral phosphoric acids. AU - Feng,Jingchao, AU - Yan,Wenjin, AU - Wang,Dong, AU - Li,Peng, AU - Sun,Quantao, AU - Wang,Rui, Y1 - 2012/07/06/ PY - 2012/7/10/entrez PY - 2012/7/10/pubmed PY - 2012/11/13/medline SP - 8003 EP - 5 JF - Chemical communications (Cambridge, England) JO - Chem Commun (Camb) VL - 48 IS - 64 N2 - The first asymmetric aza-Friedel-Crafts reaction of indoles and pyrroles with isatin-derived N-Boc ketimines catalyzed by chiral phosphoric acids is reported. In general, derivatives of substituted 3-amino-2-oxindoles were obtained with excellent enantioselectivities and high yields. SN - 1364-548X UR - https://www.unboundmedicine.com/medline/citation/22773055/The_highly_enantioselective_addition_of_indoles_and_pyrroles_to_isatins_derived_N_Boc_ketimines_catalyzed_by_chiral_phosphoric_acids_ L2 - https://doi.org/10.1039/c2cc33200k DB - PRIME DP - Unbound Medicine ER -
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