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Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.
J Nat Prod. 2012 Jul 27; 75(7):1400-4.JN

Abstract

Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data. 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Ohlendorf B
Kieler Wirkstoff-Zentrum (KiWiZ) at the Helmholtz-Zenrum für Ozeanforschung GEOMAR , Am Kiel-Kanal 44, 24106 Kiel, Germany.
Schulz D
No affiliation info available
Erhard A
No affiliation info available
Nagel K
No affiliation info available
Imhoff JF
No affiliation info available

MeSH

Anti-Bacterial AgentsBacillus subtilisCandida albicansCholinesterase InhibitorsFibroblastsHumansMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPhenazinesStreptomycesXanthomonas campestris

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22775474

Citation

Ohlendorf, Birgit, et al. "Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced By a Streptomyces Species." Journal of Natural Products, vol. 75, no. 7, 2012, pp. 1400-4.
Ohlendorf B, Schulz D, Erhard A, et al. Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species. J Nat Prod. 2012;75(7):1400-4.
Ohlendorf, B., Schulz, D., Erhard, A., Nagel, K., & Imhoff, J. F. (2012). Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species. Journal of Natural Products, 75(7), 1400-4. https://doi.org/10.1021/np2009626
Ohlendorf B, et al. Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced By a Streptomyces Species. J Nat Prod. 2012 Jul 27;75(7):1400-4. PubMed PMID: 22775474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species. AU - Ohlendorf,Birgit, AU - Schulz,Dirk, AU - Erhard,Arlette, AU - Nagel,Kerstin, AU - Imhoff,Johannes F, Y1 - 2012/07/09/ PY - 2012/7/11/entrez PY - 2012/7/11/pubmed PY - 2012/11/7/medline SP - 1400 EP - 4 JF - Journal of natural products JO - J Nat Prod VL - 75 IS - 7 N2 - Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data. 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/22775474/Geranylphenazinediol_an_acetylcholinesterase_inhibitor_produced_by_a_Streptomyces_species_ L2 - https://doi.org/10.1021/np2009626 DB - PRIME DP - Unbound Medicine ER -