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Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment.
Neuroimage. 2012 Oct 15; 63(1):320-7.N

Abstract

Abnormalities of functional connectivity in the default mode network (DMN) recently have been reported in patients with amnestic mild cognitive impairment (aMCI), Alzheimer's disease (AD) or other psychiatric diseases. As such, these abnormalities may be epiphenomena instead of playing a causal role in AD progression. To date, few studies have investigated specific brain networks, which extend beyond the DMN involved in the early AD stages, especially in aMCI. The insula is one site affected by early pathological changes in AD and is a crucial hub of the human brain networks. Currently, we explored the contribution of the insula networks to cognitive performance in aMCI patients. Thirty aMCI and 26 cognitively normal (CN) subjects participated in this study. Intrinsic connectivity of the insula networks was measured, using the resting-state functional connectivity fMRI approach. We examined the differential connectivity of insula networks between groups, and the neural correlation between the altered insula networks connectivity and the cognitive performance in aMCI patients and CN subjects, respectively. Insula subregional volumes were also investigated. AMCI subjects, when compared to CN subjects, showed significantly reduced right posterior insula volumes, cognitive deficits and disrupted intrinsic connectivity of the insula networks. Specifically, decreased intrinsic connectivity was primarily located in the frontal-parietal network and the cingulo-opercular network, including the anterior prefrontal cortex (aPFC), anterior cingulate cortex, operculum, inferior parietal cortex and precuneus. Increased intrinsic connectivity was primarily situated in the visual-auditory pathway, which included the posterior superior temporal gyrus and middle occipital gyrus. Conjunction analysis was performed; and significantly decreased intrinsic connectivity in the overlapping regions of the anterior and posterior insula networks, including the bilateral aPFC, left dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and anterior temporal pole was found. Furthermore, the disrupted intrinsic connectivity was associated with episodic memory (EM) deficits in the aMCI patients and not in the CN subjects. These findings demonstrated that the functional integration of the insula networks plays an important role in the EM process. They provided new insight into the neural mechanism underlying the memory deficits in aMCI patients.

Authors+Show Affiliations

Department of Neuropsychiatry, Affiliated ZhongDa Hospital of Southeast University, Nanjing, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22776459

Citation

Xie, Chunming, et al. "Abnormal Insula Functional Network Is Associated With Episodic Memory Decline in Amnestic Mild Cognitive Impairment." NeuroImage, vol. 63, no. 1, 2012, pp. 320-7.
Xie C, Bai F, Yu H, et al. Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment. Neuroimage. 2012;63(1):320-7.
Xie, C., Bai, F., Yu, H., Shi, Y., Yuan, Y., Chen, G., Li, W., Chen, G., Zhang, Z., & Li, S. J. (2012). Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment. NeuroImage, 63(1), 320-7. https://doi.org/10.1016/j.neuroimage.2012.06.062
Xie C, et al. Abnormal Insula Functional Network Is Associated With Episodic Memory Decline in Amnestic Mild Cognitive Impairment. Neuroimage. 2012 Oct 15;63(1):320-7. PubMed PMID: 22776459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment. AU - Xie,Chunming, AU - Bai,Feng, AU - Yu,Hui, AU - Shi,Yongmei, AU - Yuan,Yonggui, AU - Chen,Gang, AU - Li,Wenjun, AU - Chen,Guangyu, AU - Zhang,Zhijun, AU - Li,Shi-Jiang, Y1 - 2012/07/06/ PY - 2012/02/13/received PY - 2012/06/23/revised PY - 2012/06/28/accepted PY - 2012/7/11/entrez PY - 2012/7/11/pubmed PY - 2013/1/30/medline SP - 320 EP - 7 JF - NeuroImage JO - Neuroimage VL - 63 IS - 1 N2 - Abnormalities of functional connectivity in the default mode network (DMN) recently have been reported in patients with amnestic mild cognitive impairment (aMCI), Alzheimer's disease (AD) or other psychiatric diseases. As such, these abnormalities may be epiphenomena instead of playing a causal role in AD progression. To date, few studies have investigated specific brain networks, which extend beyond the DMN involved in the early AD stages, especially in aMCI. The insula is one site affected by early pathological changes in AD and is a crucial hub of the human brain networks. Currently, we explored the contribution of the insula networks to cognitive performance in aMCI patients. Thirty aMCI and 26 cognitively normal (CN) subjects participated in this study. Intrinsic connectivity of the insula networks was measured, using the resting-state functional connectivity fMRI approach. We examined the differential connectivity of insula networks between groups, and the neural correlation between the altered insula networks connectivity and the cognitive performance in aMCI patients and CN subjects, respectively. Insula subregional volumes were also investigated. AMCI subjects, when compared to CN subjects, showed significantly reduced right posterior insula volumes, cognitive deficits and disrupted intrinsic connectivity of the insula networks. Specifically, decreased intrinsic connectivity was primarily located in the frontal-parietal network and the cingulo-opercular network, including the anterior prefrontal cortex (aPFC), anterior cingulate cortex, operculum, inferior parietal cortex and precuneus. Increased intrinsic connectivity was primarily situated in the visual-auditory pathway, which included the posterior superior temporal gyrus and middle occipital gyrus. Conjunction analysis was performed; and significantly decreased intrinsic connectivity in the overlapping regions of the anterior and posterior insula networks, including the bilateral aPFC, left dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and anterior temporal pole was found. Furthermore, the disrupted intrinsic connectivity was associated with episodic memory (EM) deficits in the aMCI patients and not in the CN subjects. These findings demonstrated that the functional integration of the insula networks plays an important role in the EM process. They provided new insight into the neural mechanism underlying the memory deficits in aMCI patients. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/22776459/Abnormal_insula_functional_network_is_associated_with_episodic_memory_decline_in_amnestic_mild_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(12)00678-7 DB - PRIME DP - Unbound Medicine ER -