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Cranberry-containing products for prevention of urinary tract infections in susceptible populations: a systematic review and meta-analysis of randomized controlled trials.
Arch Intern Med. 2012 Jul 09; 172(13):988-96.AI

Abstract

BACKGROUND

Urinary tract infection (UTI) is one of the most commonly acquired bacterial infections. Cranberry-containing products have long been used as a folk remedy to prevent UTIs. The aims of this study were to evaluate cranberry-containing products for the prevention of UTI and to examine the factors influencing their effectiveness.

METHODS

MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were systemically searched from inception to November 2011 for randomized controlled trials that compared prevention of UTIs in users of cranberry-containing products vs placebo or nonplacebo controls. There were no restrictions for language, population, or publication year.

RESULTS

Thirteen trials, including 1616 subjects, were identified for qualitative synthesis from 414 potentially relevant references; 10 of these trials, including a total of 1494 subjects, were further analyzed in quantitative synthesis. The random-effects pooled risk ratio (RR) for cranberry users vs nonusers was 0.62 (95% CI, 0.49-0.80), with a moderate degree of heterogeneity (I(2) = 43%) after the exclusion of 1 outlier study. On subgroup analysis, cranberry-containing products seemed to be more effective in several subgroups, including women with recurrent UTIs (RR, 0.53; 95% CI, 0.33-0.83) (I(2) = 0%), female populations (RR, 0.49; 95% CI, 0.34-0.73) (I(2) = 34%), children (RR, 0.33; 95% CI, 0.16-0.69) (I(2) = 0%), cranberry juice drinkers (RR, 0.47; 95% CI, 0.30-0.72) (I(2) = 2%), and subjects using cranberry-containing products more than twice daily (RR, 0.58; 95% CI, 0.40-0.84) (I(2) = 18%).

CONCLUSIONS

Our findings indicate that cranberry-containing products are associated with protective effect against UTIs. However, this result should be interpreted in the context of substantial heterogeneity across trials.

Authors+Show Affiliations

Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

22777630

Citation

Wang, Chih-Hung, et al. "Cranberry-containing Products for Prevention of Urinary Tract Infections in Susceptible Populations: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Archives of Internal Medicine, vol. 172, no. 13, 2012, pp. 988-96.
Wang CH, Fang CC, Chen NC, et al. Cranberry-containing products for prevention of urinary tract infections in susceptible populations: a systematic review and meta-analysis of randomized controlled trials. Arch Intern Med. 2012;172(13):988-96.
Wang, C. H., Fang, C. C., Chen, N. C., Liu, S. S., Yu, P. H., Wu, T. Y., Chen, W. T., Lee, C. C., & Chen, S. C. (2012). Cranberry-containing products for prevention of urinary tract infections in susceptible populations: a systematic review and meta-analysis of randomized controlled trials. Archives of Internal Medicine, 172(13), 988-96. https://doi.org/10.1001/archinternmed.2012.3004
Wang CH, et al. Cranberry-containing Products for Prevention of Urinary Tract Infections in Susceptible Populations: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2012 Jul 9;172(13):988-96. PubMed PMID: 22777630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cranberry-containing products for prevention of urinary tract infections in susceptible populations: a systematic review and meta-analysis of randomized controlled trials. AU - Wang,Chih-Hung, AU - Fang,Cheng-Chung, AU - Chen,Nai-Chuan, AU - Liu,Sot Shih-Hung, AU - Yu,Ping-Hsun, AU - Wu,Tao-Yu, AU - Chen,Wei-Ting, AU - Lee,Chien-Chang, AU - Chen,Shyr-Chyr, PY - 2012/7/11/entrez PY - 2012/7/11/pubmed PY - 2012/9/18/medline SP - 988 EP - 96 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 172 IS - 13 N2 - BACKGROUND: Urinary tract infection (UTI) is one of the most commonly acquired bacterial infections. Cranberry-containing products have long been used as a folk remedy to prevent UTIs. The aims of this study were to evaluate cranberry-containing products for the prevention of UTI and to examine the factors influencing their effectiveness. METHODS: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were systemically searched from inception to November 2011 for randomized controlled trials that compared prevention of UTIs in users of cranberry-containing products vs placebo or nonplacebo controls. There were no restrictions for language, population, or publication year. RESULTS: Thirteen trials, including 1616 subjects, were identified for qualitative synthesis from 414 potentially relevant references; 10 of these trials, including a total of 1494 subjects, were further analyzed in quantitative synthesis. The random-effects pooled risk ratio (RR) for cranberry users vs nonusers was 0.62 (95% CI, 0.49-0.80), with a moderate degree of heterogeneity (I(2) = 43%) after the exclusion of 1 outlier study. On subgroup analysis, cranberry-containing products seemed to be more effective in several subgroups, including women with recurrent UTIs (RR, 0.53; 95% CI, 0.33-0.83) (I(2) = 0%), female populations (RR, 0.49; 95% CI, 0.34-0.73) (I(2) = 34%), children (RR, 0.33; 95% CI, 0.16-0.69) (I(2) = 0%), cranberry juice drinkers (RR, 0.47; 95% CI, 0.30-0.72) (I(2) = 2%), and subjects using cranberry-containing products more than twice daily (RR, 0.58; 95% CI, 0.40-0.84) (I(2) = 18%). CONCLUSIONS: Our findings indicate that cranberry-containing products are associated with protective effect against UTIs. However, this result should be interpreted in the context of substantial heterogeneity across trials. SN - 1538-3679 UR - https://www.unboundmedicine.com/medline/citation/22777630/Cranberry_containing_products_for_prevention_of_urinary_tract_infections_in_susceptible_populations:_a_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinternmed.2012.3004 DB - PRIME DP - Unbound Medicine ER -