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Protective effects of aqueous extract of Hammada scoparia against hepatotoxicity induced by ethanol in the rat.
Toxicol Ind Health 2014; 30(2):113-22TI

Abstract

Aqueous extract (AE) of Hammada scoparia leaves was chemically characterized and its hepatoprotective activities were investigated in vivo in rat model. Wistar rats were treated daily with 35% ethanol solution (3 g/kg/day) during 4 weeks and fed with basal diet or basal diet containing AE (200 mg/kg/day). Control rats were treated with saline solution and fed with basal diet. The bioactivity of AE against ethanol-induced oxidative stress in rat liver was studied in order to explore its hepatoprotective effects. H. scoparia extract used at 200 mg/kg body weight significantly prevented the effects of ethanol, which induced a hepatic pathological damage and increased the levels of the serum markers of the enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). Concomitantly, with these changes, this extract also prevented ethanol-induced oxidative stress in the rat liver as evidenced by the decreased lipid peroxidation level, a considerable decrease in the activities of AST, ALT and ALP and restoring the activities of antioxidant enzymes: superoxide dismutase, catalase and glutathione peroxidase. These biochemical changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the AE of H. scoparia.

Authors+Show Affiliations

1Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, University of Sfax, Sfax, Tunisie.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22778112

Citation

Bourogaa, Ezzeddine, et al. "Protective Effects of Aqueous Extract of Hammada Scoparia Against Hepatotoxicity Induced By Ethanol in the Rat." Toxicology and Industrial Health, vol. 30, no. 2, 2014, pp. 113-22.
Bourogaa E, Jarraya RM, Nciri R, et al. Protective effects of aqueous extract of Hammada scoparia against hepatotoxicity induced by ethanol in the rat. Toxicol Ind Health. 2014;30(2):113-22.
Bourogaa, E., Jarraya, R. M., Nciri, R., Damak, M., & Elfeki, A. (2014). Protective effects of aqueous extract of Hammada scoparia against hepatotoxicity induced by ethanol in the rat. Toxicology and Industrial Health, 30(2), pp. 113-22. doi:10.1177/0748233712452602.
Bourogaa E, et al. Protective Effects of Aqueous Extract of Hammada Scoparia Against Hepatotoxicity Induced By Ethanol in the Rat. Toxicol Ind Health. 2014;30(2):113-22. PubMed PMID: 22778112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of aqueous extract of Hammada scoparia against hepatotoxicity induced by ethanol in the rat. AU - Bourogaa,Ezzeddine, AU - Jarraya,Raoudha Mezghani, AU - Nciri,Riadh, AU - Damak,Mohamed, AU - Elfeki,Abdelfattah, Y1 - 2012/07/09/ PY - 2012/7/11/entrez PY - 2012/7/11/pubmed PY - 2014/10/22/medline KW - Hammada scoparia KW - antioxidant activity KW - ethanol KW - hepatoprotective effect KW - liver KW - oxidative stress SP - 113 EP - 22 JF - Toxicology and industrial health JO - Toxicol Ind Health VL - 30 IS - 2 N2 - Aqueous extract (AE) of Hammada scoparia leaves was chemically characterized and its hepatoprotective activities were investigated in vivo in rat model. Wistar rats were treated daily with 35% ethanol solution (3 g/kg/day) during 4 weeks and fed with basal diet or basal diet containing AE (200 mg/kg/day). Control rats were treated with saline solution and fed with basal diet. The bioactivity of AE against ethanol-induced oxidative stress in rat liver was studied in order to explore its hepatoprotective effects. H. scoparia extract used at 200 mg/kg body weight significantly prevented the effects of ethanol, which induced a hepatic pathological damage and increased the levels of the serum markers of the enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). Concomitantly, with these changes, this extract also prevented ethanol-induced oxidative stress in the rat liver as evidenced by the decreased lipid peroxidation level, a considerable decrease in the activities of AST, ALT and ALP and restoring the activities of antioxidant enzymes: superoxide dismutase, catalase and glutathione peroxidase. These biochemical changes were consistent with histopathological observations suggesting marked hepatoprotective effect of the AE of H. scoparia. SN - 1477-0393 UR - https://www.unboundmedicine.com/medline/citation/22778112/Protective_effects_of_aqueous_extract_of_Hammada_scoparia_against_hepatotoxicity_induced_by_ethanol_in_the_rat_ L2 - http://journals.sagepub.com/doi/full/10.1177/0748233712452602?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -