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Effects of a dietary intervention and weight change on vasomotor symptoms in the Women's Health Initiative.
Menopause 2012; 19(9):980-8M

Abstract

OBJECTIVE

The aim of this study was to determine whether a dietary intervention designed to reduce fat intake and increase intake of fruit, vegetables, and whole grains, and weight loss, reduces vasomotor symptoms (VMS; ie, hot flashes or night sweats) in postmenopausal women.

METHODS

We included 17,473 postmenopausal US women, ages 50 to 79 years, at baseline who participated in the Women's Health Initiative Dietary Modification trial and were not taking menopausal hormone therapy. Logistic regression was used to evaluate associations.

RESULTS

In multivariate-adjusted analyses, with simultaneous adjustment for the intervention and weight change, assignment to the dietary intervention versus the control arm was significantly (odds ratio [OR], 1.14; 95% CI, 1.01-1.28) related to a higher likelihood of symptom elimination among women with VMS at baseline. In addition, women with symptoms at baseline who lost 10 lb or more (OR, 1.23; 95% CI, 1.05-1.46) or lost 10% or more of their baseline body weight (OR, 1.56; 95% CI, 1.21-2.02) between baseline and year 1 were significantly more likely to eliminate VMS compared with those who maintained weight. Upon examining the joint effect of the dietary modification and weight loss, compared with women in the control arm who maintained weight, women who lost substantial weight (≥ 10%) as a part of the intervention (OR, 1.89; 95% CI, 1.39-2.57) but not as part of the control arm (OR, 1.40; 95% CI, 0.92-2.13) were significantly more likely to end VMS, although these two groups did not differ significantly from each other. Large weight loss (>22 lb), but not dietary changes, was related to the elimination of moderate/severe VMS.

CONCLUSIONS

Weight loss as part of a healthy dietary modification may help eliminate VMS among postmenopausal women.

Authors+Show Affiliations

Division of Research, Kaiser Permanente, Oakland, CA, USA. candyce.h.kroenke@kp.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22781782

Citation

Kroenke, Candyce H., et al. "Effects of a Dietary Intervention and Weight Change On Vasomotor Symptoms in the Women's Health Initiative." Menopause (New York, N.Y.), vol. 19, no. 9, 2012, pp. 980-8.
Kroenke CH, Caan BJ, Stefanick ML, et al. Effects of a dietary intervention and weight change on vasomotor symptoms in the Women's Health Initiative. Menopause. 2012;19(9):980-8.
Kroenke, C. H., Caan, B. J., Stefanick, M. L., Anderson, G., Brzyski, R., Johnson, K. C., ... Wallace, R. (2012). Effects of a dietary intervention and weight change on vasomotor symptoms in the Women's Health Initiative. Menopause (New York, N.Y.), 19(9), pp. 980-8.
Kroenke CH, et al. Effects of a Dietary Intervention and Weight Change On Vasomotor Symptoms in the Women's Health Initiative. Menopause. 2012;19(9):980-8. PubMed PMID: 22781782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a dietary intervention and weight change on vasomotor symptoms in the Women's Health Initiative. AU - Kroenke,Candyce H, AU - Caan,Bette J, AU - Stefanick,Marcia L, AU - Anderson,Garnet, AU - Brzyski,Robert, AU - Johnson,Karen C, AU - LeBlanc,Erin, AU - Lee,Cathy, AU - La Croix,Andrea Z, AU - Park,Hannah Lui, AU - Sims,Stacy T, AU - Vitolins,Mara, AU - Wallace,Robert, PY - 2012/7/12/entrez PY - 2012/7/12/pubmed PY - 2013/1/4/medline SP - 980 EP - 8 JF - Menopause (New York, N.Y.) JO - Menopause VL - 19 IS - 9 N2 - OBJECTIVE: The aim of this study was to determine whether a dietary intervention designed to reduce fat intake and increase intake of fruit, vegetables, and whole grains, and weight loss, reduces vasomotor symptoms (VMS; ie, hot flashes or night sweats) in postmenopausal women. METHODS: We included 17,473 postmenopausal US women, ages 50 to 79 years, at baseline who participated in the Women's Health Initiative Dietary Modification trial and were not taking menopausal hormone therapy. Logistic regression was used to evaluate associations. RESULTS: In multivariate-adjusted analyses, with simultaneous adjustment for the intervention and weight change, assignment to the dietary intervention versus the control arm was significantly (odds ratio [OR], 1.14; 95% CI, 1.01-1.28) related to a higher likelihood of symptom elimination among women with VMS at baseline. In addition, women with symptoms at baseline who lost 10 lb or more (OR, 1.23; 95% CI, 1.05-1.46) or lost 10% or more of their baseline body weight (OR, 1.56; 95% CI, 1.21-2.02) between baseline and year 1 were significantly more likely to eliminate VMS compared with those who maintained weight. Upon examining the joint effect of the dietary modification and weight loss, compared with women in the control arm who maintained weight, women who lost substantial weight (≥ 10%) as a part of the intervention (OR, 1.89; 95% CI, 1.39-2.57) but not as part of the control arm (OR, 1.40; 95% CI, 0.92-2.13) were significantly more likely to end VMS, although these two groups did not differ significantly from each other. Large weight loss (>22 lb), but not dietary changes, was related to the elimination of moderate/severe VMS. CONCLUSIONS: Weight loss as part of a healthy dietary modification may help eliminate VMS among postmenopausal women. SN - 1530-0374 UR - https://www.unboundmedicine.com/medline/citation/22781782/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=22781782 DB - PRIME DP - Unbound Medicine ER -