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[The effects of Guanxinshutong on protection of left ventricular function after acute myocardial infarction in rats].
Zhonghua Nei Ke Za Zhi. 2012 Mar; 51(3):225-7.ZN

Abstract

OBJECTIVE

To assess the effects of Guanxinshutong capsule (GXST) on protection of left ventricular (LV) function after acute myocardial infarction (AMI) in rats.

METHODS

Twenty-eight male Sprague Dawley rats were randomized to Model group, Drug group and Sham-operated group, with acute myocardial infarction (AMI) achieved by ligating coronary artery in Model and Drug groups. From one week before surgery to four weeks after surgery, GXST for Drug group (1.5 g/kg, 2 times/day) or saline for Model and Sham-operated groups was administered via direct gastric gavage. After four weeks of treatment following surgery, measurement of LV function, pathohistological observation and analysis were performed.

RESULTS

Compared with rats in the Model group, LV systolic pressure (LVSP) [(97.7 ± 9.0) mm Hg (1 mm Hg = 0.133 kPa) vs (85.9 ± 9.4) mm Hg], the maximum rising rate of LV pressure (+dp/dtmax) [(4810.2 ± 595.0) mm Hg/s vs (3786.2 ± 723.0) mm Hg/s] and the maximum dropping rate of LV pressure (-dp/dtmax) [(3781.6 ± 573.6) mm Hg/s vs (2774.4 ± 633.5)mm Hg/s] in the Drug group were significantly increased, while LV end-diastolic pressure (LVEDP) [(10.3 ± 0.7) mm Hg vs (12.7 ± 2.4) mm Hg] in the Drug group was significantly decreased (all P < 0.05). Myocardial pathohistological morphology was improved in the Drug group with fibrosis alleviated [(5.13 ± 1.37)% vs (7.27 ± 1.01)%] and infarct size reduced [(20.14 ± 8.49)% vs (31.90 ± 4.98)%]. Apoptosis index (AI) was decreased [(14.05 ± 4.04)% vs (20.87 ± 6.03)%] and vessel density was significantly increased by 1.48-fold in the Drug group (all P < 0.05).

CONCLUSIONS

GXST is effective in protecting LV function after AMI in rats, which may be affect through increasing vessel density of infarction area, improving myocardial pathohistological morphology, alleviating fibrosis, reducing infarct size and decreasing AI.

Authors+Show Affiliations

Department of Cardiology, Shenyang Northern Hospital, Shenyang 110016, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

22781899

Citation

Liang, Zhuo, et al. "[The Effects of Guanxinshutong On Protection of Left Ventricular Function After Acute Myocardial Infarction in Rats]." Zhonghua Nei Ke Za Zhi, vol. 51, no. 3, 2012, pp. 225-7.
Liang Z, Yao TM, Huo Y, et al. [The effects of Guanxinshutong on protection of left ventricular function after acute myocardial infarction in rats]. Zhonghua Nei Ke Za Zhi. 2012;51(3):225-7.
Liang, Z., Yao, T. M., Huo, Y., & Han, Y. L. (2012). [The effects of Guanxinshutong on protection of left ventricular function after acute myocardial infarction in rats]. Zhonghua Nei Ke Za Zhi, 51(3), 225-7.
Liang Z, et al. [The Effects of Guanxinshutong On Protection of Left Ventricular Function After Acute Myocardial Infarction in Rats]. Zhonghua Nei Ke Za Zhi. 2012;51(3):225-7. PubMed PMID: 22781899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effects of Guanxinshutong on protection of left ventricular function after acute myocardial infarction in rats]. AU - Liang,Zhuo, AU - Yao,Tian-ming, AU - Huo,Yu, AU - Han,Ya-ling, PY - 2012/7/12/entrez PY - 2012/7/12/pubmed PY - 2013/3/15/medline SP - 225 EP - 7 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 51 IS - 3 N2 - OBJECTIVE: To assess the effects of Guanxinshutong capsule (GXST) on protection of left ventricular (LV) function after acute myocardial infarction (AMI) in rats. METHODS: Twenty-eight male Sprague Dawley rats were randomized to Model group, Drug group and Sham-operated group, with acute myocardial infarction (AMI) achieved by ligating coronary artery in Model and Drug groups. From one week before surgery to four weeks after surgery, GXST for Drug group (1.5 g/kg, 2 times/day) or saline for Model and Sham-operated groups was administered via direct gastric gavage. After four weeks of treatment following surgery, measurement of LV function, pathohistological observation and analysis were performed. RESULTS: Compared with rats in the Model group, LV systolic pressure (LVSP) [(97.7 ± 9.0) mm Hg (1 mm Hg = 0.133 kPa) vs (85.9 ± 9.4) mm Hg], the maximum rising rate of LV pressure (+dp/dtmax) [(4810.2 ± 595.0) mm Hg/s vs (3786.2 ± 723.0) mm Hg/s] and the maximum dropping rate of LV pressure (-dp/dtmax) [(3781.6 ± 573.6) mm Hg/s vs (2774.4 ± 633.5)mm Hg/s] in the Drug group were significantly increased, while LV end-diastolic pressure (LVEDP) [(10.3 ± 0.7) mm Hg vs (12.7 ± 2.4) mm Hg] in the Drug group was significantly decreased (all P < 0.05). Myocardial pathohistological morphology was improved in the Drug group with fibrosis alleviated [(5.13 ± 1.37)% vs (7.27 ± 1.01)%] and infarct size reduced [(20.14 ± 8.49)% vs (31.90 ± 4.98)%]. Apoptosis index (AI) was decreased [(14.05 ± 4.04)% vs (20.87 ± 6.03)%] and vessel density was significantly increased by 1.48-fold in the Drug group (all P < 0.05). CONCLUSIONS: GXST is effective in protecting LV function after AMI in rats, which may be affect through increasing vessel density of infarction area, improving myocardial pathohistological morphology, alleviating fibrosis, reducing infarct size and decreasing AI. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/22781899/[The_effects_of_Guanxinshutong_on_protection_of_left_ventricular_function_after_acute_myocardial_infarction_in_rats]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0578-1426&amp;year=2012&amp;vol=51&amp;issue=3&amp;fpage=225 DB - PRIME DP - Unbound Medicine ER -