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Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV).
Addict Biol. 2014 Mar; 19(2):165-74.AB

Abstract

Reports of abuse and toxic effects of synthetic cathinones, frequently sold as 'bath salts' or 'legal highs', have increased dramatically in recent years. One of the most widely used synthetic cathinones is 3,4-methylenedioxypyrovalerone (MDPV). The current study evaluated the abuse potential of MDPV by assessing its ability to support intravenous self-administration and to lower thresholds for intracranial self-stimulation (ICSS) in rats. In the first experiment, the rats were trained to intravenously self-administer MDPV in daily 2-hour sessions for 10 days at doses of 0.05, 0.1 or 0.2 mg/kg per infusion. The rats were then allowed to self-administer MDPV under a progressive ratio (PR) schedule of reinforcement. Next, the rats self-administered MDPV for an additional 10 days under short access (ShA; 2 hours/day) or long access (LgA; 6 hours/day) conditions to assess escalation of intake. A separate group of rats underwent the same procedures, with the exception of self-administering methamphetamine (0.05 mg/kg per infusion) instead of MDPV. In the second experiment, the effects of MDPV on ICSS thresholds following acute administration (0.1, 0.5, 1 and 2 mg/kg, i.p.) were assessed. MDPV maintained self-administration across all doses tested. A positive relationship between MDPV dose and breakpoints for reinforcement under PR conditions was observed. LgA conditions led to escalation of drug intake at 0.1 and 0.2 mg/kg doses, and rats self-administering methamphetamine showed similar patterns of escalation. Finally, MDPV significantly lowered ICSS thresholds at all doses tested. Together, these findings indicate that MDPV has reinforcing properties and activates brain reward circuitry, suggesting a potential for abuse and addiction in humans.

Authors+Show Affiliations

Department of Psychology, Arizona State University, Tempe, AZ, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22784198

Citation

Watterson, Lucas R., et al. "Potent Rewarding and Reinforcing Effects of the Synthetic Cathinone 3,4-methylenedioxypyrovalerone (MDPV)." Addiction Biology, vol. 19, no. 2, 2014, pp. 165-74.
Watterson LR, Kufahl PR, Nemirovsky NE, et al. Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV). Addict Biol. 2014;19(2):165-74.
Watterson, L. R., Kufahl, P. R., Nemirovsky, N. E., Sewalia, K., Grabenauer, M., Thomas, B. F., Marusich, J. A., Wegner, S., & Olive, M. F. (2014). Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV). Addiction Biology, 19(2), 165-74. https://doi.org/10.1111/j.1369-1600.2012.00474.x
Watterson LR, et al. Potent Rewarding and Reinforcing Effects of the Synthetic Cathinone 3,4-methylenedioxypyrovalerone (MDPV). Addict Biol. 2014;19(2):165-74. PubMed PMID: 22784198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV). AU - Watterson,Lucas R, AU - Kufahl,Peter R, AU - Nemirovsky,Natali E, AU - Sewalia,Kaveish, AU - Grabenauer,Megan, AU - Thomas,Brian F, AU - Marusich,Julie A, AU - Wegner,Scott, AU - Olive,M Foster, Y1 - 2012/07/11/ PY - 2012/7/13/entrez PY - 2012/7/13/pubmed PY - 2014/12/15/medline KW - 3 KW - 4-methylenedioxypyrovalerone KW - abuse liability KW - bath salt KW - extended access KW - intracranial self-stimulation KW - intravenous self-administration KW - synthetic cathinone SP - 165 EP - 74 JF - Addiction biology JO - Addict Biol VL - 19 IS - 2 N2 - Reports of abuse and toxic effects of synthetic cathinones, frequently sold as 'bath salts' or 'legal highs', have increased dramatically in recent years. One of the most widely used synthetic cathinones is 3,4-methylenedioxypyrovalerone (MDPV). The current study evaluated the abuse potential of MDPV by assessing its ability to support intravenous self-administration and to lower thresholds for intracranial self-stimulation (ICSS) in rats. In the first experiment, the rats were trained to intravenously self-administer MDPV in daily 2-hour sessions for 10 days at doses of 0.05, 0.1 or 0.2 mg/kg per infusion. The rats were then allowed to self-administer MDPV under a progressive ratio (PR) schedule of reinforcement. Next, the rats self-administered MDPV for an additional 10 days under short access (ShA; 2 hours/day) or long access (LgA; 6 hours/day) conditions to assess escalation of intake. A separate group of rats underwent the same procedures, with the exception of self-administering methamphetamine (0.05 mg/kg per infusion) instead of MDPV. In the second experiment, the effects of MDPV on ICSS thresholds following acute administration (0.1, 0.5, 1 and 2 mg/kg, i.p.) were assessed. MDPV maintained self-administration across all doses tested. A positive relationship between MDPV dose and breakpoints for reinforcement under PR conditions was observed. LgA conditions led to escalation of drug intake at 0.1 and 0.2 mg/kg doses, and rats self-administering methamphetamine showed similar patterns of escalation. Finally, MDPV significantly lowered ICSS thresholds at all doses tested. Together, these findings indicate that MDPV has reinforcing properties and activates brain reward circuitry, suggesting a potential for abuse and addiction in humans. SN - 1369-1600 UR - https://www.unboundmedicine.com/medline/citation/22784198/Potent_rewarding_and_reinforcing_effects_of_the_synthetic_cathinone_34_methylenedioxypyrovalerone__MDPV__ L2 - https://doi.org/10.1111/j.1369-1600.2012.00474.x DB - PRIME DP - Unbound Medicine ER -