The spectrum of vitamin B12 deficiency.
Am Fam Physician. 1990 Jan; 41(1):150-62.AF

Abstract

Low serum vitamin B12 levels are not uncommon in the elderly. Patients with vitamin B12 deficiency manifest a spectrum of clinical findings. Pernicious anemia and malabsorption syndrome are the usual causes of vitamin B12 deficiency. Pernicious anemia is confirmed by the presence of intrinsic factor blocking antibody or abnormal results on the Schilling test. Patients with neuropsychiatric symptoms of vitamin B12 deficiency may have a normal Schilling test and no evidence of macrocytic anemia. In such patients, vitamin B12 deficiency is confirmed by determining serum levels of homocysteine and methylmalonic acid.

Authors+Show Affiliations

Clementz GL

University of Illinois College of Medicine, Peoria.

Schade SG

No affiliation info available

MeSH

HumansMalabsorption SyndromesSchilling TestVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

2278533

Citation

Clementz, G L., and S G. Schade. "The Spectrum of Vitamin B12 Deficiency." American Family Physician, vol. 41, no. 1, 1990, pp. 150-62.

Clementz GL, Schade SG. The spectrum of vitamin B12 deficiency. Am Fam Physician. 1990;41(1):150-62.

Clementz, G. L., & Schade, S. G. (1990). The spectrum of vitamin B12 deficiency. American Family Physician, 41(1), 150-62.

Clementz GL, Schade SG. The Spectrum of Vitamin B12 Deficiency. Am Fam Physician. 1990;41(1):150-62. PubMed PMID: 2278533.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - The spectrum of vitamin B12 deficiency. AU - Clementz,G L, AU - Schade,S G, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 150 EP - 62 JF - American family physician JO - Am Fam Physician VL - 41 IS - 1 N2 - Low serum vitamin B12 levels are not uncommon in the elderly. Patients with vitamin B12 deficiency manifest a spectrum of clinical findings. Pernicious anemia and malabsorption syndrome are the usual causes of vitamin B12 deficiency. Pernicious anemia is confirmed by the presence of intrinsic factor blocking antibody or abnormal results on the Schilling test. Patients with neuropsychiatric symptoms of vitamin B12 deficiency may have a normal Schilling test and no evidence of macrocytic anemia. In such patients, vitamin B12 deficiency is confirmed by determining serum levels of homocysteine and methylmalonic acid. SN - 0002-838X UR - https://www.unboundmedicine.com/medline/citation/2278533/The_spectrum_of_vitamin_B12_deficiency_ DB - PRIME DP - Unbound Medicine ER -

Tags

The spectrum of vitamin B12 deficiency.Am Fam Physician. 1990 Jan; 41(1):150-62.AF