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Effects of turpentine-induced inflammation on the hypoxic stimulation of intestinal Fe3+ absorption in mice.
Int J Exp Pathol. 1990 Dec; 71(6):785-9.IJ

Abstract

Chronic subcutaneous turpentine administration (weekly for 6 weeks) induced a mild normocytic anaemia in mice. In-vitro and in-vivo intestinal Fe3+ absorption parameters were, however, not significantly altered from values in saline-treated or untreated mice. Normal mice, when exposed to 3 days hypoxia demonstrated a 2-3-fold increase in iron absorption in vivo, mainly due to changes in the amount of iron transferred from the mucosa to the plasma and thence to the carcass. A 2-3-fold increase in Vmax was also observed in in-vitro uptake experiments using isolated duodenal fragments. In contrast, turpentine-treated animals, though demonstrating an enhanced in-vitro maximal uptake capacity, failed to elicit an adaptive response in vivo following hypoxic exposure. These findings suggest that a circulating (humoral) factor may be responsible for the inhibition in absorption in vivo in this turpentine-induced inflammatory model.

Authors+Show Affiliations

Department of Clinical Biochemistry, King's College School of Medicine and Dentistry, Denmark Hill, London, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2278822

Citation

Raja, K B., et al. "Effects of Turpentine-induced Inflammation On the Hypoxic Stimulation of Intestinal Fe3+ Absorption in Mice." International Journal of Experimental Pathology, vol. 71, no. 6, 1990, pp. 785-9.
Raja KB, Duane P, Peters TJ. Effects of turpentine-induced inflammation on the hypoxic stimulation of intestinal Fe3+ absorption in mice. Int J Exp Pathol. 1990;71(6):785-9.
Raja, K. B., Duane, P., & Peters, T. J. (1990). Effects of turpentine-induced inflammation on the hypoxic stimulation of intestinal Fe3+ absorption in mice. International Journal of Experimental Pathology, 71(6), 785-9.
Raja KB, Duane P, Peters TJ. Effects of Turpentine-induced Inflammation On the Hypoxic Stimulation of Intestinal Fe3+ Absorption in Mice. Int J Exp Pathol. 1990;71(6):785-9. PubMed PMID: 2278822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of turpentine-induced inflammation on the hypoxic stimulation of intestinal Fe3+ absorption in mice. AU - Raja,K B, AU - Duane,P, AU - Peters,T J, PY - 1990/12/1/pubmed PY - 1990/12/1/medline PY - 1990/12/1/entrez SP - 785 EP - 9 JF - International journal of experimental pathology JO - Int J Exp Pathol VL - 71 IS - 6 N2 - Chronic subcutaneous turpentine administration (weekly for 6 weeks) induced a mild normocytic anaemia in mice. In-vitro and in-vivo intestinal Fe3+ absorption parameters were, however, not significantly altered from values in saline-treated or untreated mice. Normal mice, when exposed to 3 days hypoxia demonstrated a 2-3-fold increase in iron absorption in vivo, mainly due to changes in the amount of iron transferred from the mucosa to the plasma and thence to the carcass. A 2-3-fold increase in Vmax was also observed in in-vitro uptake experiments using isolated duodenal fragments. In contrast, turpentine-treated animals, though demonstrating an enhanced in-vitro maximal uptake capacity, failed to elicit an adaptive response in vivo following hypoxic exposure. These findings suggest that a circulating (humoral) factor may be responsible for the inhibition in absorption in vivo in this turpentine-induced inflammatory model. SN - 0959-9673 UR - https://www.unboundmedicine.com/medline/citation/2278822/Effects_of_turpentine_induced_inflammation_on_the_hypoxic_stimulation_of_intestinal_Fe3+_absorption_in_mice_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0959-9673&date=1990&volume=71&issue=6&spage=785 DB - PRIME DP - Unbound Medicine ER -