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Formulation development and optimization of bilayer tablets of aceclofenac.
Expert Opin Drug Deliv. 2012 Sep; 9(9):1041-50.EO

Abstract

OBJECTIVE

The objective of the present study was to develop bilayer tablets of aceclofenac that are characterized by initial burst drug release followed by sustained release of drug.

METHODS

The fast-release layer of the bilayer tablet was formulated using microcrystaline cellulose (MCC) and HPMC K4M. The amount of HPMC E4M (X(1)) and MCC (X(2)) was used as independent variables for optimization of sustained release formulation applying 3(2) factorial design. Three dependent variables were considered: percentage of aceclofenac release at 1 h, percentage of aceclofenac release at 12 h, and time to release 50% of drug (t(50%)). The composition of optimum formulation of sustained release tablets were employed to formulate double layer tablets.

RESULTS

The results indicate that X(1) and X(2) significantly affected the release properties of aceclofenac from sustained release formulation. The double layer tablets containing fast-release layer showed an initial burst drug release of more than 30% of its drug content during first 1 h followed by sustained release of the drug for a period of 24 h.

CONCLUSION

The double layer tablets for aceclofenac can be successfully employed as once-a-day oral-controlled release drug delivery system characterized by initial burst release of aceclofenac for providing the loading dose of drug.

Authors+Show Affiliations

Dibrugarh University, Department of Pharmaceutical Sciences, Dibrugarh-786004, Assam, India. sanju1980dey@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22788786

Citation

Dey, Sanjay, et al. "Formulation Development and Optimization of Bilayer Tablets of Aceclofenac." Expert Opinion On Drug Delivery, vol. 9, no. 9, 2012, pp. 1041-50.
Dey S, Mahanti B, Khila S, et al. Formulation development and optimization of bilayer tablets of aceclofenac. Expert Opin Drug Deliv. 2012;9(9):1041-50.
Dey, S., Mahanti, B., Khila, S., Mazumder, B., & Gupta, S. D. (2012). Formulation development and optimization of bilayer tablets of aceclofenac. Expert Opinion On Drug Delivery, 9(9), 1041-50. https://doi.org/10.1517/17425247.2012.707187
Dey S, et al. Formulation Development and Optimization of Bilayer Tablets of Aceclofenac. Expert Opin Drug Deliv. 2012;9(9):1041-50. PubMed PMID: 22788786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation development and optimization of bilayer tablets of aceclofenac. AU - Dey,Sanjay, AU - Mahanti,Beduin, AU - Khila,Sudip, AU - Mazumder,Bhaskar, AU - Gupta,Sadipan Das, Y1 - 2012/07/12/ PY - 2012/7/14/entrez PY - 2012/7/14/pubmed PY - 2013/4/26/medline SP - 1041 EP - 50 JF - Expert opinion on drug delivery JO - Expert Opin Drug Deliv VL - 9 IS - 9 N2 - OBJECTIVE: The objective of the present study was to develop bilayer tablets of aceclofenac that are characterized by initial burst drug release followed by sustained release of drug. METHODS: The fast-release layer of the bilayer tablet was formulated using microcrystaline cellulose (MCC) and HPMC K4M. The amount of HPMC E4M (X(1)) and MCC (X(2)) was used as independent variables for optimization of sustained release formulation applying 3(2) factorial design. Three dependent variables were considered: percentage of aceclofenac release at 1 h, percentage of aceclofenac release at 12 h, and time to release 50% of drug (t(50%)). The composition of optimum formulation of sustained release tablets were employed to formulate double layer tablets. RESULTS: The results indicate that X(1) and X(2) significantly affected the release properties of aceclofenac from sustained release formulation. The double layer tablets containing fast-release layer showed an initial burst drug release of more than 30% of its drug content during first 1 h followed by sustained release of the drug for a period of 24 h. CONCLUSION: The double layer tablets for aceclofenac can be successfully employed as once-a-day oral-controlled release drug delivery system characterized by initial burst release of aceclofenac for providing the loading dose of drug. SN - 1744-7593 UR - https://www.unboundmedicine.com/medline/citation/22788786/Formulation_development_and_optimization_of_bilayer_tablets_of_aceclofenac_ L2 - https://www.tandfonline.com/doi/full/10.1517/17425247.2012.707187 DB - PRIME DP - Unbound Medicine ER -