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High-density lipoprotein cholesterol and the risk of nephropathy in type 2 diabetic patients.
Nutr Metab Cardiovasc Dis. 2013 Aug; 23(8):751-7.NM

Abstract

BACKGROUND AND AIMS

To date, few studies have demonstrated the impact of variations in blood pressure, blood glucose and lipid levels on the progression of diabetic nephropathy (DN) in type 2 diabetic patients. This study aimed to assess the associations of mean values and variability in metabolic parameters with the development of DN in type 2 diabetic patients.

METHODS AND RESULTS

A total of 864 patients who had participated in a comprehensive diabetic care program for at least for 3 years were studied. Patients were stratified into progressor (n = 180) and non-progressor groups (n = 684) according to the status of progression of DN during the follow-up period. By Cox regression analysis, a higher mean HDL-C level was observed to be a protective factor against the progression of DN [hazard ratio (95% CI): 0.971(0.953-0.989), P = 0.002] and a higher HDL-C variation was found to be associated with a higher risk [hazard ratio (95% CI): 1.177(1.032-1.341), P = 0.015] of DN progression. By the Kaplan-Meier survival curve, patients with a higher HDL-C level and lower HDL-C variability were found to have the lowest risk of development of nephropathy.

CONCLUSIONS

Our study demonstrated for the first time that type 2 diabetic patients under a standard disease management program who have a stable and a higher mean HDL-C level were associated with a lower risk of development of DN.

Authors+Show Affiliations

Lee's Endocrinology Clinic, # 130 Min-Tzu Rd, Pingtung 90000, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22789808

Citation

Chang, Y-H, et al. "High-density Lipoprotein Cholesterol and the Risk of Nephropathy in Type 2 Diabetic Patients." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 23, no. 8, 2013, pp. 751-7.
Chang YH, Chang DM, Lin KC, et al. High-density lipoprotein cholesterol and the risk of nephropathy in type 2 diabetic patients. Nutr Metab Cardiovasc Dis. 2013;23(8):751-7.
Chang, Y. H., Chang, D. M., Lin, K. C., Hsieh, C. H., & Lee, Y. J. (2013). High-density lipoprotein cholesterol and the risk of nephropathy in type 2 diabetic patients. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 23(8), 751-7. https://doi.org/10.1016/j.numecd.2012.05.005
Chang YH, et al. High-density Lipoprotein Cholesterol and the Risk of Nephropathy in Type 2 Diabetic Patients. Nutr Metab Cardiovasc Dis. 2013;23(8):751-7. PubMed PMID: 22789808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-density lipoprotein cholesterol and the risk of nephropathy in type 2 diabetic patients. AU - Chang,Y-H, AU - Chang,D-M, AU - Lin,K-C, AU - Hsieh,C-H, AU - Lee,Y-J, Y1 - 2012/07/11/ PY - 2011/11/30/received PY - 2012/03/22/revised PY - 2012/05/16/accepted PY - 2012/7/14/entrez PY - 2012/7/14/pubmed PY - 2014/2/6/medline KW - Diabetic nephropathy KW - High-density lipoprotein cholesterol KW - Type 2 diabetes mellitus SP - 751 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 23 IS - 8 N2 - BACKGROUND AND AIMS: To date, few studies have demonstrated the impact of variations in blood pressure, blood glucose and lipid levels on the progression of diabetic nephropathy (DN) in type 2 diabetic patients. This study aimed to assess the associations of mean values and variability in metabolic parameters with the development of DN in type 2 diabetic patients. METHODS AND RESULTS: A total of 864 patients who had participated in a comprehensive diabetic care program for at least for 3 years were studied. Patients were stratified into progressor (n = 180) and non-progressor groups (n = 684) according to the status of progression of DN during the follow-up period. By Cox regression analysis, a higher mean HDL-C level was observed to be a protective factor against the progression of DN [hazard ratio (95% CI): 0.971(0.953-0.989), P = 0.002] and a higher HDL-C variation was found to be associated with a higher risk [hazard ratio (95% CI): 1.177(1.032-1.341), P = 0.015] of DN progression. By the Kaplan-Meier survival curve, patients with a higher HDL-C level and lower HDL-C variability were found to have the lowest risk of development of nephropathy. CONCLUSIONS: Our study demonstrated for the first time that type 2 diabetic patients under a standard disease management program who have a stable and a higher mean HDL-C level were associated with a lower risk of development of DN. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/22789808/High_density_lipoprotein_cholesterol_and_the_risk_of_nephropathy_in_type_2_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(12)00145-7 DB - PRIME DP - Unbound Medicine ER -