Tags

Type your tag names separated by a space and hit enter

Electrochemistry of metoclopramide at multi-walled carbon nanotube modified electrode and its voltammetric detection.
Anal Sci. 2012; 28(7):693-8.AS

Abstract

A simple, sensitive and inexpensive electrochemical method was developed for the determination of metoclopramide (MCP) with a multi-wall carbon nanotube (MWNT) modified glassy carbon electrode (GCE). MWNT was dispersed into polyacrylic acid (PAA); the aqueous suspension was then cast on GCE electrodes, forming MWNT-PAA films after evaporation of the solvent. The electrochemical behavior of MCP at the MWNT-modified electrode was investigated in detail. Compared with the bare GCE, the MWNT-modified electrode exhibits electrocatalytic activity to the oxidation of MCP because of the significant oxidation peak-current enhancement. Furthermore, various experimental parameters, such as the solution pH value, the amount of MWNT-PAA suspension and accumulation conditions were optimized for the determination of MCP. Based on the electrocatalytic effect of the MWNT-modified electrode, linear sweep voltammetry (LSV) was developed for the determination of MCP with the linear response in the range from 1.0 × 10(-7) to 1.0 × 10(-5) mol L(-1) and a detection limit of 5.0 × 10(-8) mol L(-1). The method has been successfully applied to the determination of MCP in commercial MCP tablets.

Links

FREE Publisher Full Text

Authors+Show Affiliations

Guo W
Department of Chemistry, Xinxiang Medical University, Xinxiang, Henan,P R China.
Geng M
No affiliation info available
Zhou L
No affiliation info available

MeSH

Acrylic ResinsCalibrationElectrochemistryElectrodesGlassHydrogen-Ion ConcentrationMetoclopramideNanotubes, CarbonTablets

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22790372

Citation

Guo, Wei, et al. "Electrochemistry of Metoclopramide at Multi-walled Carbon Nanotube Modified Electrode and Its Voltammetric Detection." Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry, vol. 28, no. 7, 2012, pp. 693-8.
Guo W, Geng M, Zhou L. Electrochemistry of metoclopramide at multi-walled carbon nanotube modified electrode and its voltammetric detection. Anal Sci. 2012;28(7):693-8.
Guo, W., Geng, M., & Zhou, L. (2012). Electrochemistry of metoclopramide at multi-walled carbon nanotube modified electrode and its voltammetric detection. Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry, 28(7), 693-8.
Guo W, Geng M, Zhou L. Electrochemistry of Metoclopramide at Multi-walled Carbon Nanotube Modified Electrode and Its Voltammetric Detection. Anal Sci. 2012;28(7):693-8. PubMed PMID: 22790372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemistry of metoclopramide at multi-walled carbon nanotube modified electrode and its voltammetric detection. AU - Guo,Wei, AU - Geng,Mingjiang, AU - Zhou,Lingyun, PY - 2012/7/14/entrez PY - 2012/7/14/pubmed PY - 2012/12/10/medline SP - 693 EP - 8 JF - Analytical sciences : the international journal of the Japan Society for Analytical Chemistry JO - Anal Sci VL - 28 IS - 7 N2 - A simple, sensitive and inexpensive electrochemical method was developed for the determination of metoclopramide (MCP) with a multi-wall carbon nanotube (MWNT) modified glassy carbon electrode (GCE). MWNT was dispersed into polyacrylic acid (PAA); the aqueous suspension was then cast on GCE electrodes, forming MWNT-PAA films after evaporation of the solvent. The electrochemical behavior of MCP at the MWNT-modified electrode was investigated in detail. Compared with the bare GCE, the MWNT-modified electrode exhibits electrocatalytic activity to the oxidation of MCP because of the significant oxidation peak-current enhancement. Furthermore, various experimental parameters, such as the solution pH value, the amount of MWNT-PAA suspension and accumulation conditions were optimized for the determination of MCP. Based on the electrocatalytic effect of the MWNT-modified electrode, linear sweep voltammetry (LSV) was developed for the determination of MCP with the linear response in the range from 1.0 × 10(-7) to 1.0 × 10(-5) mol L(-1) and a detection limit of 5.0 × 10(-8) mol L(-1). The method has been successfully applied to the determination of MCP in commercial MCP tablets. SN - 1348-2246 UR - https://www.unboundmedicine.com/medline/citation/22790372/Electrochemistry_of_metoclopramide_at_multi_walled_carbon_nanotube_modified_electrode_and_its_voltammetric_detection_ L2 - http://japanlinkcenter.org/DN/JST.JSTAGE/analsci/28.693?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -