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Chiari malformation in nonsyndromal single craniosynostosis--much ado about nothing?
Acta Neurochir (Wien). 2012 Oct; 154(10):1803-7.AN

Abstract

BACKGROUND

The significance of Chiari malformation in nonsyndromal-isolated craniosynostosis is still not well documented. Hence, in the present study we investigated the incidence of Chiari malformation in a larger series of patients with nonsyndromic-isolated single-suture craniosynostosis over a 9-year period using preoperative magnetic resonance imaging (MRI).

METHODS

Of 215 children who had undergone surgery for nonsyndromic-isolated craniosynostosis, 89 cases (41.4 %) had MRI prior to surgery. All MRIs were screened for Chiari malformation.

RESULTS

Only one patient (1.1 %) with isolated lambdoid synostosis showed Chiari malformation preoperatively, which was defined as a cerebellar tonsillar descent greater than 5 mm below the foramen magnum. However, no clinical symptoms were associated with Chiari malformation in this patient.

CONCLUSIONS

As Chiari malformation is more likely to be associated with syndromic craniosynostosis, nonsyndromic bilateral coronal synostosis, or synostosis of the lambdoid suture, a general use of MRI as a screening tool for Chiari malformation should not be recommended for patients with nonsyndromic-isolated craniosynostosis who lack clinical symptoms.

Authors+Show Affiliations

Department of Oral and Maxillofacial Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany. michael.engel@med.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22790904

Citation

Engel, M, et al. "Chiari Malformation in Nonsyndromal Single Craniosynostosis--much Ado About Nothing?" Acta Neurochirurgica, vol. 154, no. 10, 2012, pp. 1803-7.
Engel M, Castrillón-Oberndorfer G, Hoffmann J, et al. Chiari malformation in nonsyndromal single craniosynostosis--much ado about nothing? Acta Neurochir (Wien). 2012;154(10):1803-7.
Engel, M., Castrillón-Oberndorfer, G., Hoffmann, J., Orakcioglu, B., Rohde, S., Seeberger, R., & Freudlsperger, C. (2012). Chiari malformation in nonsyndromal single craniosynostosis--much ado about nothing? Acta Neurochirurgica, 154(10), 1803-7. https://doi.org/10.1007/s00701-012-1439-5
Engel M, et al. Chiari Malformation in Nonsyndromal Single Craniosynostosis--much Ado About Nothing. Acta Neurochir (Wien). 2012;154(10):1803-7. PubMed PMID: 22790904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chiari malformation in nonsyndromal single craniosynostosis--much ado about nothing? AU - Engel,M, AU - Castrillón-Oberndorfer,G, AU - Hoffmann,J, AU - Orakcioglu,B, AU - Rohde,S, AU - Seeberger,R, AU - Freudlsperger,C, Y1 - 2012/07/13/ PY - 2012/04/16/received PY - 2012/06/21/accepted PY - 2012/7/14/entrez PY - 2012/7/14/pubmed PY - 2013/3/13/medline SP - 1803 EP - 7 JF - Acta neurochirurgica JO - Acta Neurochir (Wien) VL - 154 IS - 10 N2 - BACKGROUND: The significance of Chiari malformation in nonsyndromal-isolated craniosynostosis is still not well documented. Hence, in the present study we investigated the incidence of Chiari malformation in a larger series of patients with nonsyndromic-isolated single-suture craniosynostosis over a 9-year period using preoperative magnetic resonance imaging (MRI). METHODS: Of 215 children who had undergone surgery for nonsyndromic-isolated craniosynostosis, 89 cases (41.4 %) had MRI prior to surgery. All MRIs were screened for Chiari malformation. RESULTS: Only one patient (1.1 %) with isolated lambdoid synostosis showed Chiari malformation preoperatively, which was defined as a cerebellar tonsillar descent greater than 5 mm below the foramen magnum. However, no clinical symptoms were associated with Chiari malformation in this patient. CONCLUSIONS: As Chiari malformation is more likely to be associated with syndromic craniosynostosis, nonsyndromic bilateral coronal synostosis, or synostosis of the lambdoid suture, a general use of MRI as a screening tool for Chiari malformation should not be recommended for patients with nonsyndromic-isolated craniosynostosis who lack clinical symptoms. SN - 0942-0940 UR - https://www.unboundmedicine.com/medline/citation/22790904/Chiari_malformation_in_nonsyndromal_single_craniosynostosis__much_ado_about_nothing DB - PRIME DP - Unbound Medicine ER -