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Long-term recordings of local field potentials from implanted deep brain stimulation electrodes.
Neurosurgery. 2012 Oct; 71(4):804-14.N

Abstract

BACKGROUND

Deep brain stimulation (DBS) of the subthalamic nucleus is an effective treatment for Parkinson disease. However, DBS is not responsive to an individual's disease state, and programming parameters, once established, do not change to reflect disease state. Local field potentials (LFPs) recorded from DBS electrodes are being investigated as potential biomarkers for the Parkinson disease state. However, no patient data exist about what happens to LFPs over the lifetime of the implant.

OBJECTIVE

We investigated whether LFP amplitude and response to limb movement differed between patients implanted acutely with subthalamic nucleus DBS electrodes and patients implanted 2 to 7 years previously.

METHODS

We recorded LFPs at DBS surgery time (9 subjects), 3 weeks after initial placement (9 subjects), and 2 to 7 years (median: 3.5) later during implanted programmable generator replacement (11 sides). LFP power-frequency spectra for each of 3 bipolar electrode derivations of adjacent contacts were calculated over 5-minute resting and 30-second movement epochs. Monopolar impedance data were used to evaluate trends over time.

RESULTS

There was no significant difference in β-band LFP amplitude between initial electrode implantation (OR) and 3-week post-OR times (P=.94). However, β-band amplitude was lower at implanted programmable generator replacement times than in OR (P=.008) and post-OR recordings (P=.039). Impedance measurements declined over time (P<.001).

CONCLUSION

Postoperative LFP activity can be recorded years after DBS implantation and demonstrates a similar profile in response to movement as during acute recordings, although amplitude may decrease. These results support the feasibility of constructing a closed-loop, patient-responsive DBS device based on LFP activity.

Authors+Show Affiliations

Department of Neurosurgery, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55414, USA. aabosch@umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22791039

Citation

Abosch, Aviva, et al. "Long-term Recordings of Local Field Potentials From Implanted Deep Brain Stimulation Electrodes." Neurosurgery, vol. 71, no. 4, 2012, pp. 804-14.
Abosch A, Lanctin D, Onaran I, et al. Long-term recordings of local field potentials from implanted deep brain stimulation electrodes. Neurosurgery. 2012;71(4):804-14.
Abosch, A., Lanctin, D., Onaran, I., Eberly, L., Spaniol, M., & Ince, N. F. (2012). Long-term recordings of local field potentials from implanted deep brain stimulation electrodes. Neurosurgery, 71(4), 804-14.
Abosch A, et al. Long-term Recordings of Local Field Potentials From Implanted Deep Brain Stimulation Electrodes. Neurosurgery. 2012;71(4):804-14. PubMed PMID: 22791039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term recordings of local field potentials from implanted deep brain stimulation electrodes. AU - Abosch,Aviva, AU - Lanctin,David, AU - Onaran,Ibrahim, AU - Eberly,Lynn, AU - Spaniol,Maggie, AU - Ince,Nuri Firat, PY - 2012/7/14/entrez PY - 2012/7/14/pubmed PY - 2013/2/28/medline SP - 804 EP - 14 JF - Neurosurgery JO - Neurosurgery VL - 71 IS - 4 N2 - BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus is an effective treatment for Parkinson disease. However, DBS is not responsive to an individual's disease state, and programming parameters, once established, do not change to reflect disease state. Local field potentials (LFPs) recorded from DBS electrodes are being investigated as potential biomarkers for the Parkinson disease state. However, no patient data exist about what happens to LFPs over the lifetime of the implant. OBJECTIVE: We investigated whether LFP amplitude and response to limb movement differed between patients implanted acutely with subthalamic nucleus DBS electrodes and patients implanted 2 to 7 years previously. METHODS: We recorded LFPs at DBS surgery time (9 subjects), 3 weeks after initial placement (9 subjects), and 2 to 7 years (median: 3.5) later during implanted programmable generator replacement (11 sides). LFP power-frequency spectra for each of 3 bipolar electrode derivations of adjacent contacts were calculated over 5-minute resting and 30-second movement epochs. Monopolar impedance data were used to evaluate trends over time. RESULTS: There was no significant difference in β-band LFP amplitude between initial electrode implantation (OR) and 3-week post-OR times (P=.94). However, β-band amplitude was lower at implanted programmable generator replacement times than in OR (P=.008) and post-OR recordings (P=.039). Impedance measurements declined over time (P<.001). CONCLUSION: Postoperative LFP activity can be recorded years after DBS implantation and demonstrates a similar profile in response to movement as during acute recordings, although amplitude may decrease. These results support the feasibility of constructing a closed-loop, patient-responsive DBS device based on LFP activity. SN - 1524-4040 UR - https://www.unboundmedicine.com/medline/citation/22791039/Long_term_recordings_of_local_field_potentials_from_implanted_deep_brain_stimulation_electrodes_ L2 - https://academic.oup.com/neurosurgery/article-lookup/doi/10.1227/NEU.0b013e3182676b91 DB - PRIME DP - Unbound Medicine ER -