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A cell population that strongly expresses the CB1 cannabinoid receptor in the ependyma of the rat spinal cord.
J Comp Neurol. 2013 Jan 01; 521(1):233-51.JC

Abstract

The cells surrounding the central canal of the spinal cord are a source of stem/precursor cells that may give rise to neurons, astrocytes, or oligodendrocytes. However, they are a heterogeneous population that remains poorly understood. Here we describe a subpopulation characterized by their strong expression of the CB(1) cannabinoid receptor, oval/round soma, apical nucleus, a variable number of cilia (0, 1, or 2), and the presence of a single short and occasionally ramified basal process. These cells are mainly located in the lateral and dorsal central canal throughout the spinal cord. These CB(1)(HIGH) cells are closely related to the basal lamina labyrinths or fractones derived from subependymal microglia. In addition, CB(1)(HIGH) cells express some stem/precursor cell markers, including vimentin, nestin, Sox2, Sox9, and GLAST, but not others such as CD15 or GFAP. In addition, this cell population does not proliferate in the intact adult spinal cord, although up to 50% of these cells express the proliferation marker Ki67 in newly born rats or after a spinal cord contusion. The present findings contribute to our understanding of the spinal cord central canal structure and reveal the targets for endocannabinoids inside this neurogenic niche.

Authors+Show Affiliations

Laboratorio de Neuroinflamacion, Unidad de Neurologia Experimental, Hospital Nacional de Paraplejicos, Toledo 45071, Spain. dgarciao@sescam.jccm.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22791629

Citation

Garcia-Ovejero, Daniel, et al. "A Cell Population That Strongly Expresses the CB1 Cannabinoid Receptor in the Ependyma of the Rat Spinal Cord." The Journal of Comparative Neurology, vol. 521, no. 1, 2013, pp. 233-51.
Garcia-Ovejero D, Arevalo-Martin A, Paniagua-Torija B, et al. A cell population that strongly expresses the CB1 cannabinoid receptor in the ependyma of the rat spinal cord. J Comp Neurol. 2013;521(1):233-51.
Garcia-Ovejero, D., Arevalo-Martin, A., Paniagua-Torija, B., Sierra-Palomares, Y., & Molina-Holgado, E. (2013). A cell population that strongly expresses the CB1 cannabinoid receptor in the ependyma of the rat spinal cord. The Journal of Comparative Neurology, 521(1), 233-51. https://doi.org/10.1002/cne.23184
Garcia-Ovejero D, et al. A Cell Population That Strongly Expresses the CB1 Cannabinoid Receptor in the Ependyma of the Rat Spinal Cord. J Comp Neurol. 2013 Jan 1;521(1):233-51. PubMed PMID: 22791629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cell population that strongly expresses the CB1 cannabinoid receptor in the ependyma of the rat spinal cord. AU - Garcia-Ovejero,Daniel, AU - Arevalo-Martin,Angel, AU - Paniagua-Torija,Beatriz, AU - Sierra-Palomares,Yolanda, AU - Molina-Holgado,Eduardo, PY - 2012/04/26/received PY - 2012/06/22/revised PY - 2012/07/06/accepted PY - 2012/7/14/entrez PY - 2012/7/14/pubmed PY - 2013/3/9/medline SP - 233 EP - 51 JF - The Journal of comparative neurology JO - J Comp Neurol VL - 521 IS - 1 N2 - The cells surrounding the central canal of the spinal cord are a source of stem/precursor cells that may give rise to neurons, astrocytes, or oligodendrocytes. However, they are a heterogeneous population that remains poorly understood. Here we describe a subpopulation characterized by their strong expression of the CB(1) cannabinoid receptor, oval/round soma, apical nucleus, a variable number of cilia (0, 1, or 2), and the presence of a single short and occasionally ramified basal process. These cells are mainly located in the lateral and dorsal central canal throughout the spinal cord. These CB(1)(HIGH) cells are closely related to the basal lamina labyrinths or fractones derived from subependymal microglia. In addition, CB(1)(HIGH) cells express some stem/precursor cell markers, including vimentin, nestin, Sox2, Sox9, and GLAST, but not others such as CD15 or GFAP. In addition, this cell population does not proliferate in the intact adult spinal cord, although up to 50% of these cells express the proliferation marker Ki67 in newly born rats or after a spinal cord contusion. The present findings contribute to our understanding of the spinal cord central canal structure and reveal the targets for endocannabinoids inside this neurogenic niche. SN - 1096-9861 UR - https://www.unboundmedicine.com/medline/citation/22791629/A_cell_population_that_strongly_expresses_the_CB1_cannabinoid_receptor_in_the_ependyma_of_the_rat_spinal_cord_ L2 - https://doi.org/10.1002/cne.23184 DB - PRIME DP - Unbound Medicine ER -