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Stem cell-based therapy for malignant glioma.
Cancer Treat Rev 2013; 39(4):358-65CT

Abstract

Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation and tumour neovascularisation can specifically attract stem cells to invasive gliomas. Injected stem cells engineered to produce anti-tumour substances have shown strong therapeutic effects in experimental glioma models. However, the potential caveats include the immunosuppressive functions of multipotent mesenchymal stromal cells, the contribution of stem cells to the pro-tumourigenic stroma, and the malignant transformation of implanted stem cells. In addition, it is not yet known which stem cell types and therapeutic genes will be most effective for the treatment of glioma patients. Here, we highlight the possibilities and problems for translating promising experimental findings in glioma models into the clinic.

Authors+Show Affiliations

Lund Stem Cell Center, BMC B10, Lund University, Lund, Sweden; Molecular Medicine, Center for Molecular Pathology, Lund University, Skåne University Hospital, Malmö, Sweden. daniel.bexell@med.lu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22795538

Citation

Bexell, Daniel, et al. "Stem Cell-based Therapy for Malignant Glioma." Cancer Treatment Reviews, vol. 39, no. 4, 2013, pp. 358-65.
Bexell D, Svensson A, Bengzon J. Stem cell-based therapy for malignant glioma. Cancer Treat Rev. 2013;39(4):358-65.
Bexell, D., Svensson, A., & Bengzon, J. (2013). Stem cell-based therapy for malignant glioma. Cancer Treatment Reviews, 39(4), pp. 358-65. doi:10.1016/j.ctrv.2012.06.006.
Bexell D, Svensson A, Bengzon J. Stem Cell-based Therapy for Malignant Glioma. Cancer Treat Rev. 2013;39(4):358-65. PubMed PMID: 22795538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stem cell-based therapy for malignant glioma. AU - Bexell,Daniel, AU - Svensson,Andreas, AU - Bengzon,Johan, Y1 - 2012/07/13/ PY - 2012/04/10/received PY - 2012/06/13/revised PY - 2012/06/17/accepted PY - 2012/7/17/entrez PY - 2012/7/17/pubmed PY - 2013/5/11/medline SP - 358 EP - 65 JF - Cancer treatment reviews JO - Cancer Treat. Rev. VL - 39 IS - 4 N2 - Stem cells have been extensively investigated as tumour-tropic vectors for gene delivery to solid tumours. In this review, we discuss the potential for using stem cells as cellular vector systems in gene therapy for malignant gliomas, with a focus on neural stem cells, and multipotent mesenchymal stromal cells. Tumour cell-derived substances and factors associated with tumour-induced inflammation and tumour neovascularisation can specifically attract stem cells to invasive gliomas. Injected stem cells engineered to produce anti-tumour substances have shown strong therapeutic effects in experimental glioma models. However, the potential caveats include the immunosuppressive functions of multipotent mesenchymal stromal cells, the contribution of stem cells to the pro-tumourigenic stroma, and the malignant transformation of implanted stem cells. In addition, it is not yet known which stem cell types and therapeutic genes will be most effective for the treatment of glioma patients. Here, we highlight the possibilities and problems for translating promising experimental findings in glioma models into the clinic. SN - 1532-1967 UR - https://www.unboundmedicine.com/medline/citation/22795538/Stem_cell_based_therapy_for_malignant_glioma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0305-7372(12)00140-5 DB - PRIME DP - Unbound Medicine ER -