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Multi-institutional experience with the in-office potassium titanyl phosphate laser for laryngeal lesions.
J Voice. 2012 Nov; 26(6):806-10.JV

Abstract

OBJECTIVE/HYPOTHESIS

To determine the efficacy of the potassium titanyl phosphate (KTP) laser in lesion reduction, as well as preservation of mucosal wave and glottic closure in a cohort of patients with benign laryngeal pathology across multiple institutions.

STUDY DESIGN

Multi-institutional and retrospective.

METHODS

One hundred two patients who underwent in-office KTP procedures at multiple academic laryngology practices with at least a single follow-up visit were included. Image analysis was used to quantify vocal fold lesion size before and after treatment. A subset of images was analyzed by expert reviewers to determine the impact of this treatment on glottic closure and mucosal wave.

RESULTS

Statistically, when considering all lesions, KTP induced a significant reduction in lesion size. Post hoc analyses revealed some lesion specificity; all lesions decreased in size, with the exception of vocal fold scar. Mucosal wave and glottic closure were improved or unchanged in more than 90% of the patients examined. The inter- and intrarater reliabilities of the lesion quantification method were excellent.

CONCLUSIONS

With great care and insight, the KTP laser appears to be a valuable tool for the treatment of various benign laryngeal lesions. Furthermore, KTP laser therapy appears to preserve or improve mucosal wave and glottic closure. The lesion measurement protocol previously described by our group appears to be reliable.

Authors+Show Affiliations

Department of Otolaryngology, New York University School of Medicine, New York City, New York 10016, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

22795983

Citation

Sheu, Mike, et al. "Multi-institutional Experience With the In-office Potassium Titanyl Phosphate Laser for Laryngeal Lesions." Journal of Voice : Official Journal of the Voice Foundation, vol. 26, no. 6, 2012, pp. 806-10.
Sheu M, Sridharan S, Kuhn M, et al. Multi-institutional experience with the in-office potassium titanyl phosphate laser for laryngeal lesions. J Voice. 2012;26(6):806-10.
Sheu, M., Sridharan, S., Kuhn, M., Wang, S., Paul, B., Venkatesan, N., Fuller, C. W., Simpson, C. B., Johns, M., Branski, R. C., & Amin, M. R. (2012). Multi-institutional experience with the in-office potassium titanyl phosphate laser for laryngeal lesions. Journal of Voice : Official Journal of the Voice Foundation, 26(6), 806-10. https://doi.org/10.1016/j.jvoice.2012.04.003
Sheu M, et al. Multi-institutional Experience With the In-office Potassium Titanyl Phosphate Laser for Laryngeal Lesions. J Voice. 2012;26(6):806-10. PubMed PMID: 22795983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multi-institutional experience with the in-office potassium titanyl phosphate laser for laryngeal lesions. AU - Sheu,Mike, AU - Sridharan,Shaum, AU - Kuhn,Maggie, AU - Wang,Sean, AU - Paul,Benjamin, AU - Venkatesan,Naren, AU - Fuller,Colin W, AU - Simpson,C Blake, AU - Johns,Michael, AU - Branski,Ryan C, AU - Amin,Milan R, Y1 - 2012/07/13/ PY - 2012/02/21/received PY - 2012/04/18/accepted PY - 2012/7/17/entrez PY - 2012/7/17/pubmed PY - 2013/5/15/medline SP - 806 EP - 10 JF - Journal of voice : official journal of the Voice Foundation JO - J Voice VL - 26 IS - 6 N2 - OBJECTIVE/HYPOTHESIS: To determine the efficacy of the potassium titanyl phosphate (KTP) laser in lesion reduction, as well as preservation of mucosal wave and glottic closure in a cohort of patients with benign laryngeal pathology across multiple institutions. STUDY DESIGN: Multi-institutional and retrospective. METHODS: One hundred two patients who underwent in-office KTP procedures at multiple academic laryngology practices with at least a single follow-up visit were included. Image analysis was used to quantify vocal fold lesion size before and after treatment. A subset of images was analyzed by expert reviewers to determine the impact of this treatment on glottic closure and mucosal wave. RESULTS: Statistically, when considering all lesions, KTP induced a significant reduction in lesion size. Post hoc analyses revealed some lesion specificity; all lesions decreased in size, with the exception of vocal fold scar. Mucosal wave and glottic closure were improved or unchanged in more than 90% of the patients examined. The inter- and intrarater reliabilities of the lesion quantification method were excellent. CONCLUSIONS: With great care and insight, the KTP laser appears to be a valuable tool for the treatment of various benign laryngeal lesions. Furthermore, KTP laser therapy appears to preserve or improve mucosal wave and glottic closure. The lesion measurement protocol previously described by our group appears to be reliable. SN - 1873-4588 UR - https://www.unboundmedicine.com/medline/citation/22795983/Multi_institutional_experience_with_the_in_office_potassium_titanyl_phosphate_laser_for_laryngeal_lesions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0892-1997(12)00049-5 DB - PRIME DP - Unbound Medicine ER -