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Lipid effects of a dietary supplement softgel capsule containing plant sterols/stanols in primary hypercholesterolemia.
Nutrition. 2013 Jan; 29(1):96-100.N

Abstract

OBJECTIVE

This randomized, placebo-controlled, crossover trial assessed the lipid-altering efficacy of a softgel capsule dietary supplement, providing esterified plant sterols/stanols 1.8 g/d, in 28 participants (≈ 75% women) with primary hypercholesterolemia (fasting low-density lipoprotein cholesterol [LDL-C] levels ≥ 130 and <220 mg/dL), a mean age of 58.4 y, and a mean body mass index of 27.9 kg/m(2).

METHODS

After a 5-wk National Cholesterol Education Program (NCEP) Therapeutic Lifestyle Changes (TLC) diet and a single-blinded placebo lead-in, subjects received double-blinded placebo or sterol/stanol softgel capsules for 6 wk and then crossed over to the opposite product for 6 wk while continuing the TLC diet. Fasting lipids were assessed in duplicate at the end of the diet lead-in (baseline) and the end of each treatment.

RESULTS

The mean baseline lipid concentrations (milligrams per deciliter) were 223 for total cholesterol (TC), 179 for non-high-density lipoprotein cholesterol (non-HDL-C), 154 for low-density lipoprotein cholesterol, 44 for HDL-C, 125 for triacylglycerols, and 5.2 for TC/HDL-C. Differences from the control responses (plant sterol/stanol minus control) in the per-protocol sample were significant (P < 0.05) for LDL-C (-9.2%), non-HDL-C (-9.0%), TC (-7.4%), TC/HDL-C (-5.4%), and triacylglycerols (-9.1%). The HDL-C responses were not significantly different between treatments.

CONCLUSION

The incorporation of softgel capsules providing esterified plant sterols/stanols 1.8 g/d into the NCEP TLC diet produced favorable changes in atherogenic lipoprotein cholesterol levels in these subjects with hypercholesterolemia.

Authors+Show Affiliations

Biofortis Clinical Research, Addison, Illinois, USA. KMaki@mxns.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22796122

Citation

Maki, Kevin C., et al. "Lipid Effects of a Dietary Supplement Softgel Capsule Containing Plant Sterols/stanols in Primary Hypercholesterolemia." Nutrition (Burbank, Los Angeles County, Calif.), vol. 29, no. 1, 2013, pp. 96-100.
Maki KC, Lawless AL, Reeves MS, et al. Lipid effects of a dietary supplement softgel capsule containing plant sterols/stanols in primary hypercholesterolemia. Nutrition. 2013;29(1):96-100.
Maki, K. C., Lawless, A. L., Reeves, M. S., Kelley, K. M., Dicklin, M. R., Jenks, B. H., Shneyvas, E., & Brooks, J. R. (2013). Lipid effects of a dietary supplement softgel capsule containing plant sterols/stanols in primary hypercholesterolemia. Nutrition (Burbank, Los Angeles County, Calif.), 29(1), 96-100. https://doi.org/10.1016/j.nut.2012.05.002
Maki KC, et al. Lipid Effects of a Dietary Supplement Softgel Capsule Containing Plant Sterols/stanols in Primary Hypercholesterolemia. Nutrition. 2013;29(1):96-100. PubMed PMID: 22796122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid effects of a dietary supplement softgel capsule containing plant sterols/stanols in primary hypercholesterolemia. AU - Maki,Kevin C, AU - Lawless,Andrea L, AU - Reeves,Matthew S, AU - Kelley,Kathleen M, AU - Dicklin,Mary R, AU - Jenks,Belinda H, AU - Shneyvas,Ed, AU - Brooks,James R, Y1 - 2012/07/15/ PY - 2011/12/23/received PY - 2012/05/09/revised PY - 2012/05/09/accepted PY - 2012/7/17/entrez PY - 2012/7/17/pubmed PY - 2013/5/15/medline SP - 96 EP - 100 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 29 IS - 1 N2 - OBJECTIVE: This randomized, placebo-controlled, crossover trial assessed the lipid-altering efficacy of a softgel capsule dietary supplement, providing esterified plant sterols/stanols 1.8 g/d, in 28 participants (≈ 75% women) with primary hypercholesterolemia (fasting low-density lipoprotein cholesterol [LDL-C] levels ≥ 130 and <220 mg/dL), a mean age of 58.4 y, and a mean body mass index of 27.9 kg/m(2). METHODS: After a 5-wk National Cholesterol Education Program (NCEP) Therapeutic Lifestyle Changes (TLC) diet and a single-blinded placebo lead-in, subjects received double-blinded placebo or sterol/stanol softgel capsules for 6 wk and then crossed over to the opposite product for 6 wk while continuing the TLC diet. Fasting lipids were assessed in duplicate at the end of the diet lead-in (baseline) and the end of each treatment. RESULTS: The mean baseline lipid concentrations (milligrams per deciliter) were 223 for total cholesterol (TC), 179 for non-high-density lipoprotein cholesterol (non-HDL-C), 154 for low-density lipoprotein cholesterol, 44 for HDL-C, 125 for triacylglycerols, and 5.2 for TC/HDL-C. Differences from the control responses (plant sterol/stanol minus control) in the per-protocol sample were significant (P < 0.05) for LDL-C (-9.2%), non-HDL-C (-9.0%), TC (-7.4%), TC/HDL-C (-5.4%), and triacylglycerols (-9.1%). The HDL-C responses were not significantly different between treatments. CONCLUSION: The incorporation of softgel capsules providing esterified plant sterols/stanols 1.8 g/d into the NCEP TLC diet produced favorable changes in atherogenic lipoprotein cholesterol levels in these subjects with hypercholesterolemia. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/22796122/Lipid_effects_of_a_dietary_supplement_softgel_capsule_containing_plant_sterols/stanols_in_primary_hypercholesterolemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(12)00217-1 DB - PRIME DP - Unbound Medicine ER -