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Effectiveness of pandemic and seasonal influenza vaccines in preventing pandemic influenza-associated hospitalization.

Abstract

Vaccines are leading pharmacological measures for limiting the impact of pandemic influenza in the community. The objective of this study was to investigate the effectiveness of influenza (pandemic and seasonal) vaccines in preventing pandemic influenza-associated hospitalization. We conducted a multicenter matched case-control study in 36 Spanish hospitals. Patients hospitalized with confirmed pandemic influenza between November 2009 and February 2010 and two hospitalized controls per case, matched according to age, date of hospitalization and province of residence, were selected. Multivariate analysis was performed using conditional logistic regression. Subjects were considered vaccinated if they had received the vaccine >14 days (seasonal influenza vaccine) or >7 days (pandemic influenza vaccine) before the onset of symptoms (cases) or the onset of symptoms of the matched case (controls). For the pandemic influenza vaccine, vaccination effectiveness (VE) was estimated taking into account only patients recruited from November 23, 2009, seven days after the beginning of the pandemic influenza vaccination campaign. 638 cases and 1250 controls were included. The adjusted VE of the pandemic vaccine in the ≥18 years age group was 74.2% (95% CI, 29-90) and that of the influenza seasonal vaccine 15.0% (-34 to 43). The recommendation of influenza vaccination should be reinforced as a regular measure to reduce influenza-associated hospitalization during pandemics and seasonal epidemics.

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  • Authors+Show Affiliations

    ,

    Department de Salut Pública, Universitat de Barcelona, Barcelona, Spain. angela.dominguez@ub.edu

    , , , , , , , , , , , , , , , ,

    Source

    Vaccine 30:38 2012 Aug 17 pg 5644-50

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Child
    Child, Preschool
    Female
    Hospitalization
    Hospitals
    Humans
    Infant
    Infant, Newborn
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Spain
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22796136

    Citation

    Domínguez, Angela, et al. "Effectiveness of Pandemic and Seasonal Influenza Vaccines in Preventing Pandemic Influenza-associated Hospitalization." Vaccine, vol. 30, no. 38, 2012, pp. 5644-50.
    Domínguez A, Castilla J, Godoy P, et al. Effectiveness of pandemic and seasonal influenza vaccines in preventing pandemic influenza-associated hospitalization. Vaccine. 2012;30(38):5644-50.
    Domínguez, A., Castilla, J., Godoy, P., Delgado-Rodríguez, M., Martín, V., Saez, M., ... Pumarola, T. (2012). Effectiveness of pandemic and seasonal influenza vaccines in preventing pandemic influenza-associated hospitalization. Vaccine, 30(38), pp. 5644-50.
    Domínguez A, et al. Effectiveness of Pandemic and Seasonal Influenza Vaccines in Preventing Pandemic Influenza-associated Hospitalization. Vaccine. 2012 Aug 17;30(38):5644-50. PubMed PMID: 22796136.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effectiveness of pandemic and seasonal influenza vaccines in preventing pandemic influenza-associated hospitalization. AU - Domínguez,Angela, AU - Castilla,Jesús, AU - Godoy,Pere, AU - Delgado-Rodríguez,Miguel, AU - Martín,Vicente, AU - Saez,Marc, AU - Soldevila,Núria, AU - Quintana,José María, AU - Mayoral,José María, AU - Astray,Jenaro, AU - González-Candelas,Fernando, AU - Cantón,Rafael, AU - Tamames,Sonia, AU - Castro,Ady, AU - Baricot,Maretva, AU - Alonso,Jordi, AU - Pumarola,Tomás, AU - ,, Y1 - 2012/07/10/ PY - 2011/10/21/received PY - 2012/06/14/revised PY - 2012/06/29/accepted PY - 2012/7/17/entrez PY - 2012/7/17/pubmed PY - 2012/12/12/medline SP - 5644 EP - 50 JF - Vaccine JO - Vaccine VL - 30 IS - 38 N2 - Vaccines are leading pharmacological measures for limiting the impact of pandemic influenza in the community. The objective of this study was to investigate the effectiveness of influenza (pandemic and seasonal) vaccines in preventing pandemic influenza-associated hospitalization. We conducted a multicenter matched case-control study in 36 Spanish hospitals. Patients hospitalized with confirmed pandemic influenza between November 2009 and February 2010 and two hospitalized controls per case, matched according to age, date of hospitalization and province of residence, were selected. Multivariate analysis was performed using conditional logistic regression. Subjects were considered vaccinated if they had received the vaccine >14 days (seasonal influenza vaccine) or >7 days (pandemic influenza vaccine) before the onset of symptoms (cases) or the onset of symptoms of the matched case (controls). For the pandemic influenza vaccine, vaccination effectiveness (VE) was estimated taking into account only patients recruited from November 23, 2009, seven days after the beginning of the pandemic influenza vaccination campaign. 638 cases and 1250 controls were included. The adjusted VE of the pandemic vaccine in the ≥18 years age group was 74.2% (95% CI, 29-90) and that of the influenza seasonal vaccine 15.0% (-34 to 43). The recommendation of influenza vaccination should be reinforced as a regular measure to reduce influenza-associated hospitalization during pandemics and seasonal epidemics. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/22796136/Effectiveness_of_pandemic_and_seasonal_influenza_vaccines_in_preventing_pandemic_influenza_associated_hospitalization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(12)00980-2 DB - PRIME DP - Unbound Medicine ER -