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RETRACTED ARTICLE

Increased risk of stomach and esophageal malignancies in people with AIDS.
Gastroenterology 2012; 143(4):943-950.e2G

Abstract

BACKGROUND & AIMS

People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk of cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hodgkin lymphomas (NHLs) of the stomach and esophagus in people with acquired immunodeficiency syndrome (AIDS).

METHODS

We analyzed data from the HIV/AIDS Cancer Match Study, which links data collected from 1980 to 2007 for 16 US population-based HIV and AIDS and cancer registries. We compared risks of stomach and esophageal malignancies in people with AIDS (N = 596,955) with those of the general population using standardized incidence ratios (SIRs). We assessed calendar trends using Poisson regression.

RESULTS

People with AIDS had increased risks of carcinomas of the esophagus (SIR, 1.69; 95% confidence interval [CI], 1.37-2.07; n = 95) and stomach (SIR, 1.44; 95% CI, 1.17-1.76; n = 96). Risk was increased for esophageal adenocarcinoma (SIR, 1.91; 95% CI, 1.31-2.70) and squamous cell carcinoma (SIR, 1.47; 95% CI, 1.10-1.92). People with AIDS had greater risks of carcinomas of the gastric cardia (SIR, 1.36; 95% CI, 0.83-2.11) and noncardia (SIR, 1.53; 95% CI, 1.12-2.05) than the general population. Although most stomach and esophageal NHLs that developed in people with AIDS were diffuse large B-cell lymphomas, these individuals also had an increased risk of stomach mucosa-associated lymphoid tissue lymphoma (SIR, 5.99; 95% CI, 3.19-10.2; n = 13). The incidence of carcinomas remained fairly constant over time, but rates of NHL decreased from 1980 to 2007 (P(trend) < .0001).

CONCLUSIONS

People with AIDS are at increased risk for developing esophageal and stomach carcinomas and NHLs. Although the incidence of NHL decreased from 1980 to 2007 as treatments for HIV infection improved, HIV-infected individuals face continued risks of esophageal and stomach carcinomas.

Authors+Show Affiliations

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852-7234, USA. christina.persson@nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Retracted Publication

Language

eng

PubMed ID

22796240

Citation

Persson, E Christina, et al. "Increased Risk of Stomach and Esophageal Malignancies in People With AIDS." Gastroenterology, vol. 143, no. 4, 2012, pp. 943-950.e2.
Persson EC, Shiels MS, Dawsey SM, et al. Increased risk of stomach and esophageal malignancies in people with AIDS. Gastroenterology. 2012;143(4):943-950.e2.
Persson, E. C., Shiels, M. S., Dawsey, S. M., Bhatia, K., Anderson, L. A., & Engels, E. A. (2012). Increased risk of stomach and esophageal malignancies in people with AIDS. Gastroenterology, 143(4), pp. 943-950.e2. doi:10.1053/j.gastro.2012.07.013.
Persson EC, et al. Increased Risk of Stomach and Esophageal Malignancies in People With AIDS. Gastroenterology. 2012;143(4):943-950.e2. PubMed PMID: 22796240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk of stomach and esophageal malignancies in people with AIDS. AU - Persson,E Christina, AU - Shiels,Meredith S, AU - Dawsey,Sanford M, AU - Bhatia,Kishor, AU - Anderson,Lesley A, AU - Engels,Eric A, Y1 - 2012/07/14/ PY - 2012/03/16/received PY - 2012/06/21/revised PY - 2012/07/10/accepted PY - 2012/7/17/entrez PY - 2012/7/17/pubmed PY - 2012/12/18/medline SP - 943 EP - 950.e2 JF - Gastroenterology JO - Gastroenterology VL - 143 IS - 4 N2 - BACKGROUND & AIMS: People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk of cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hodgkin lymphomas (NHLs) of the stomach and esophagus in people with acquired immunodeficiency syndrome (AIDS). METHODS: We analyzed data from the HIV/AIDS Cancer Match Study, which links data collected from 1980 to 2007 for 16 US population-based HIV and AIDS and cancer registries. We compared risks of stomach and esophageal malignancies in people with AIDS (N = 596,955) with those of the general population using standardized incidence ratios (SIRs). We assessed calendar trends using Poisson regression. RESULTS: People with AIDS had increased risks of carcinomas of the esophagus (SIR, 1.69; 95% confidence interval [CI], 1.37-2.07; n = 95) and stomach (SIR, 1.44; 95% CI, 1.17-1.76; n = 96). Risk was increased for esophageal adenocarcinoma (SIR, 1.91; 95% CI, 1.31-2.70) and squamous cell carcinoma (SIR, 1.47; 95% CI, 1.10-1.92). People with AIDS had greater risks of carcinomas of the gastric cardia (SIR, 1.36; 95% CI, 0.83-2.11) and noncardia (SIR, 1.53; 95% CI, 1.12-2.05) than the general population. Although most stomach and esophageal NHLs that developed in people with AIDS were diffuse large B-cell lymphomas, these individuals also had an increased risk of stomach mucosa-associated lymphoid tissue lymphoma (SIR, 5.99; 95% CI, 3.19-10.2; n = 13). The incidence of carcinomas remained fairly constant over time, but rates of NHL decreased from 1980 to 2007 (P(trend) < .0001). CONCLUSIONS: People with AIDS are at increased risk for developing esophageal and stomach carcinomas and NHLs. Although the incidence of NHL decreased from 1980 to 2007 as treatments for HIV infection improved, HIV-infected individuals face continued risks of esophageal and stomach carcinomas. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/22796240/Increased_risk_of_stomach_and_esophageal_malignancies_in_people_with_AIDS_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(12)00963-8 DB - PRIME DP - Unbound Medicine ER -