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Composition, antimicrobial and free-radical scavenging activities of the essential oil of Plectranthus marrubatus.
Nat Prod Commun. 2012 May; 7(5):667-70.NP

Abstract

Essential oil from the aerial part of Plectranthus marrubatus J. K. Morton (Lamiaceae), obtained by hydrodistillation was analyzed by gas chromatography/mass spectrometry (GC/MS) and evaluated for antimicrobial and free radical scavenging activities. Twenty-four compounds representing 99% of the total oil were identified. The major constituents were thymol, p-cymene and gamma-terpinene. The oil was tested against 21 bacterial and 4 fungal strains using the disc diffusion method and found to be active against a broad spectrum of pathogens including Gram-positive and Gram-negative bacteria as well as some fungal strains. The minimum inhibitory concentrations (MICs) of the oil against the bacterial strains tested ranged from 10 to 800 microg/mL, and from 400 to 800 microg/mL against the fungal strains employed. The in vitro antioxidant activity was assessed using 2,2-diphenyl-l-picrylhydrazil (DPPH) and showed a low EC50 value of 0.15 microl/mL. The study provides evidence for the broad-spectrum antimicrobial and antioxidant effect of Plectranthus marrubatus essential oil, and a possible explanation for its traditional use in the treatment of cold, fever, stomach disorder, diarrhea and as a skin cleaner.

Authors+Show Affiliations

Asres K
Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia. kasres@phar.aau.edu.et
Tadesse S
No affiliation info available
Mazumder A
No affiliation info available
Bucar F
No affiliation info available

MeSH

Anti-Infective AgentsFree Radical ScavengersGas Chromatography-Mass SpectrometryMicrobial Sensitivity TestsOils, VolatilePhytotherapyPlectranthus

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22799104

Citation

Asres, Kaleab, et al. "Composition, Antimicrobial and Free-radical Scavenging Activities of the Essential Oil of Plectranthus Marrubatus." Natural Product Communications, vol. 7, no. 5, 2012, pp. 667-70.
Asres K, Tadesse S, Mazumder A, et al. Composition, antimicrobial and free-radical scavenging activities of the essential oil of Plectranthus marrubatus. Nat Prod Commun. 2012;7(5):667-70.
Asres, K., Tadesse, S., Mazumder, A., & Bucar, F. (2012). Composition, antimicrobial and free-radical scavenging activities of the essential oil of Plectranthus marrubatus. Natural Product Communications, 7(5), 667-70.
Asres K, et al. Composition, Antimicrobial and Free-radical Scavenging Activities of the Essential Oil of Plectranthus Marrubatus. Nat Prod Commun. 2012;7(5):667-70. PubMed PMID: 22799104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition, antimicrobial and free-radical scavenging activities of the essential oil of Plectranthus marrubatus. AU - Asres,Kaleab, AU - Tadesse,Solomon, AU - Mazumder,Avijit, AU - Bucar,Franz, PY - 2012/7/18/entrez PY - 2012/7/18/pubmed PY - 2012/8/7/medline SP - 667 EP - 70 JF - Natural product communications JO - Nat Prod Commun VL - 7 IS - 5 N2 - Essential oil from the aerial part of Plectranthus marrubatus J. K. Morton (Lamiaceae), obtained by hydrodistillation was analyzed by gas chromatography/mass spectrometry (GC/MS) and evaluated for antimicrobial and free radical scavenging activities. Twenty-four compounds representing 99% of the total oil were identified. The major constituents were thymol, p-cymene and gamma-terpinene. The oil was tested against 21 bacterial and 4 fungal strains using the disc diffusion method and found to be active against a broad spectrum of pathogens including Gram-positive and Gram-negative bacteria as well as some fungal strains. The minimum inhibitory concentrations (MICs) of the oil against the bacterial strains tested ranged from 10 to 800 microg/mL, and from 400 to 800 microg/mL against the fungal strains employed. The in vitro antioxidant activity was assessed using 2,2-diphenyl-l-picrylhydrazil (DPPH) and showed a low EC50 value of 0.15 microl/mL. The study provides evidence for the broad-spectrum antimicrobial and antioxidant effect of Plectranthus marrubatus essential oil, and a possible explanation for its traditional use in the treatment of cold, fever, stomach disorder, diarrhea and as a skin cleaner. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/22799104/Composition_antimicrobial_and_free_radical_scavenging_activities_of_the_essential_oil_of_Plectranthus_marrubatus_ DB - PRIME DP - Unbound Medicine ER -