Tags

Type your tag names separated by a space and hit enter

Association between moderate renal insufficiency and cardiovascular events in a general population: Tehran lipid and glucose study.
BMC Nephrol. 2012 Jul 16; 13:59.BN

Abstract

BACKGROUND

Chronic kidney disease(CKD) has been proposed as a risk factor for cardiovascular disease (CVD). There is conflicting evidence among community based studies regarding the association between CKD and CVD. Furthermore, in order to assess the possible interaction between CKD and BMI, we also examined the association between CKD and CVD, across different BMI categories.

METHODS

The risk of CVD events was evaluated in a large cohort of participants selected from the Tehran Lipid and Glucose Study. Participants(mean age, 47.4 years) free of previous CVD were followed up for 9.1 years. GFR ml/min per 1.73 m(2) was estimated using the MDRD formula.

RESULTS

Of the 6,209 participants, 22.2%(1381) had CKD with eGFR ml/min per 1.73 m(2) <60 at baseline. Almost all of them (99%) were in stage 3a. Moderate renal insufficiency only predicted CVD outcomes independently when we adjusted for age and sex. After further adjustment, the presence of moderate CKD lost its statistical significance to confer an independent increased risk of CVD events with a hazard ratio of: HR: 1.14, CI 95% 0.91-1.42. Furthermore, when participants were categorized according to CKD status and BMI groups, after further adjustment, no interaction was found(P = 0.2).

CONCLUSION

CKD was not an independent risk factor for CVD events in a community-based study in a Tehranian population and the higher prevalence of CVD in subjects with mild to moderate renal insufficiency might be due to the co-occurrence of traditional CVD risk factors in this group.

Authors+Show Affiliations

Obesity Research Center, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. fhospanah@endocrine.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22799559

Citation

Hosseinpanah, Farhad, et al. "Association Between Moderate Renal Insufficiency and Cardiovascular Events in a General Population: Tehran Lipid and Glucose Study." BMC Nephrology, vol. 13, 2012, p. 59.
Hosseinpanah F, Barzin M, Golkashani HA, et al. Association between moderate renal insufficiency and cardiovascular events in a general population: Tehran lipid and glucose study. BMC Nephrol. 2012;13:59.
Hosseinpanah, F., Barzin, M., Golkashani, H. A., Nassiri, A. A., Sheikholeslami, F., & Azizi, F. (2012). Association between moderate renal insufficiency and cardiovascular events in a general population: Tehran lipid and glucose study. BMC Nephrology, 13, 59. https://doi.org/10.1186/1471-2369-13-59
Hosseinpanah F, et al. Association Between Moderate Renal Insufficiency and Cardiovascular Events in a General Population: Tehran Lipid and Glucose Study. BMC Nephrol. 2012 Jul 16;13:59. PubMed PMID: 22799559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between moderate renal insufficiency and cardiovascular events in a general population: Tehran lipid and glucose study. AU - Hosseinpanah,Farhad, AU - Barzin,Maryam, AU - Golkashani,Hosein Aghayan, AU - Nassiri,Amir A, AU - Sheikholeslami,Farhad, AU - Azizi,Fereidoun, Y1 - 2012/07/16/ PY - 2011/10/12/received PY - 2012/07/16/accepted PY - 2012/7/18/entrez PY - 2012/7/18/pubmed PY - 2013/5/28/medline SP - 59 EP - 59 JF - BMC nephrology JO - BMC Nephrol VL - 13 N2 - BACKGROUND: Chronic kidney disease(CKD) has been proposed as a risk factor for cardiovascular disease (CVD). There is conflicting evidence among community based studies regarding the association between CKD and CVD. Furthermore, in order to assess the possible interaction between CKD and BMI, we also examined the association between CKD and CVD, across different BMI categories. METHODS: The risk of CVD events was evaluated in a large cohort of participants selected from the Tehran Lipid and Glucose Study. Participants(mean age, 47.4 years) free of previous CVD were followed up for 9.1 years. GFR ml/min per 1.73 m(2) was estimated using the MDRD formula. RESULTS: Of the 6,209 participants, 22.2%(1381) had CKD with eGFR ml/min per 1.73 m(2) <60 at baseline. Almost all of them (99%) were in stage 3a. Moderate renal insufficiency only predicted CVD outcomes independently when we adjusted for age and sex. After further adjustment, the presence of moderate CKD lost its statistical significance to confer an independent increased risk of CVD events with a hazard ratio of: HR: 1.14, CI 95% 0.91-1.42. Furthermore, when participants were categorized according to CKD status and BMI groups, after further adjustment, no interaction was found(P = 0.2). CONCLUSION: CKD was not an independent risk factor for CVD events in a community-based study in a Tehranian population and the higher prevalence of CVD in subjects with mild to moderate renal insufficiency might be due to the co-occurrence of traditional CVD risk factors in this group. SN - 1471-2369 UR - https://www.unboundmedicine.com/medline/citation/22799559/Association_between_moderate_renal_insufficiency_and_cardiovascular_events_in_a_general_population:_Tehran_lipid_and_glucose_study_ L2 - https://www.biomedcentral.com/1471-2369/13/59 DB - PRIME DP - Unbound Medicine ER -