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Buspirone blocks the enhancing effect of the anxiogenic drug RS 79948-197 on consolidation of habit memory.
Behav Brain Res. 2012 Oct 01; 234(2):299-302.BB

Abstract

Previous findings indicate that post-training administration of the anxiogenic α(2)-adrenoceptor antagonist RS 79948-197 facilitates the consolidation of dorsal striatal-dependent habit memory. The present study examined the effect of concurrent administration of the anxiolytic serotonin 5-HT(1A) receptor partial agonist buspirone on anxiety-induced facilitation of habit memory. Male Long-Evans rats were trained in a response learning version of a water plus-maze task that requires animals to learn to make the same body turn response on each trial in order to reach a hidden escape platform. Immediately following training on days 1-3, rats received peripheral injections of either saline, buspirone (1.5 mg/kg, 2.0 mg/kg, or 5.0 mg/kg), RS 79948-197 (0.1 mg/kg), or RS 79948-197 and buspirone together. Post-training injections of RS 79948-197 alone significantly enhanced memory consolidation. The highest dose of buspirone (5.0 mg/kg) also enhanced response learning. However, concurrent administration of a dose of buspirone (1.5 mg/kg) that itself had no effect on acquisition blocked the memory enhancing effects of RS 79948-197. These findings suggest that the facilitation of habit memory observed following drug-induced anxiety can be prevented by co-administration of an anxiolytic agent.

Authors+Show Affiliations

Department of Psychology, Texas A&M University, College Station, TX77843, United States.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22800923

Citation

Leong, Kah-Chung, et al. "Buspirone Blocks the Enhancing Effect of the Anxiogenic Drug RS 79948-197 On Consolidation of Habit Memory." Behavioural Brain Research, vol. 234, no. 2, 2012, pp. 299-302.
Leong KC, Goodman J, Packard MG. Buspirone blocks the enhancing effect of the anxiogenic drug RS 79948-197 on consolidation of habit memory. Behav Brain Res. 2012;234(2):299-302.
Leong, K. C., Goodman, J., & Packard, M. G. (2012). Buspirone blocks the enhancing effect of the anxiogenic drug RS 79948-197 on consolidation of habit memory. Behavioural Brain Research, 234(2), 299-302. https://doi.org/10.1016/j.bbr.2012.07.009
Leong KC, Goodman J, Packard MG. Buspirone Blocks the Enhancing Effect of the Anxiogenic Drug RS 79948-197 On Consolidation of Habit Memory. Behav Brain Res. 2012 Oct 1;234(2):299-302. PubMed PMID: 22800923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Buspirone blocks the enhancing effect of the anxiogenic drug RS 79948-197 on consolidation of habit memory. AU - Leong,Kah-Chung, AU - Goodman,Jarid, AU - Packard,Mark G, Y1 - 2012/07/16/ PY - 2012/04/04/received PY - 2012/06/25/revised PY - 2012/07/07/accepted PY - 2012/7/18/entrez PY - 2012/7/18/pubmed PY - 2013/1/23/medline SP - 299 EP - 302 JF - Behavioural brain research JO - Behav Brain Res VL - 234 IS - 2 N2 - Previous findings indicate that post-training administration of the anxiogenic α(2)-adrenoceptor antagonist RS 79948-197 facilitates the consolidation of dorsal striatal-dependent habit memory. The present study examined the effect of concurrent administration of the anxiolytic serotonin 5-HT(1A) receptor partial agonist buspirone on anxiety-induced facilitation of habit memory. Male Long-Evans rats were trained in a response learning version of a water plus-maze task that requires animals to learn to make the same body turn response on each trial in order to reach a hidden escape platform. Immediately following training on days 1-3, rats received peripheral injections of either saline, buspirone (1.5 mg/kg, 2.0 mg/kg, or 5.0 mg/kg), RS 79948-197 (0.1 mg/kg), or RS 79948-197 and buspirone together. Post-training injections of RS 79948-197 alone significantly enhanced memory consolidation. The highest dose of buspirone (5.0 mg/kg) also enhanced response learning. However, concurrent administration of a dose of buspirone (1.5 mg/kg) that itself had no effect on acquisition blocked the memory enhancing effects of RS 79948-197. These findings suggest that the facilitation of habit memory observed following drug-induced anxiety can be prevented by co-administration of an anxiolytic agent. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/22800923/Buspirone_blocks_the_enhancing_effect_of_the_anxiogenic_drug_RS_79948_197_on_consolidation_of_habit_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(12)00464-0 DB - PRIME DP - Unbound Medicine ER -