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Compliance in pharmacotherapy in patients with chronic venous disorders.
Int Angiol. 2012 Aug; 31(4):393-401.IA

Abstract

AIM

The aim of this study was to evaluate the factors that limit the use of venoactive drugs (VADs), especially in patient with chronic venous disorders (CVD) noncompliant with compression therapy in a nationwide survey.

METHODS

Analysis included 5134 CVD patients compliant with compression therapy and 4663 of those not accepting such method of therapy, participating in a large survey.

RESULTS

Venoactive drugs (VADs) and topical agents were used significantly less frequently by patients noncompliant with compression therapy compared to the compliant population (95.2% vs. 97.7%, P<0.001 and 70.1% vs. 79.9%, P<0.001, respectively). There were also less patients on two VADs concurrently in these subgroups (14.6% vs. 24.6%, P<0.001 respectively). Logistic regression analysis confirmed that noncompliant also have decreased adherence to Ruscus aculeatus extracts (OR=0.870), micronized purified flavonoid fraction (MPFF) preparations (OR=0.886), and topical agents (OR=0.877), but not horse chestnuts seed extracts. Coexisting obesity and other chronic illnesses were among the factors that decreased the use of Ruscus aculeatus extracts and micronized purified flavonoid fraction (MPFF) preparations. The use of topical agents was reduced with age, male sex, patients with coexisting chronic illnesses, obesity and adverse to accepting compression therapy. Additionally diuretics, antiplatelet agents and low-molecular weight heparins were less frequently used in the noncompliant population.

CONCLUSIONS

Patients who are not compliant with compression therapy are more frequently not adherent to pharmacological therapy. Coexisting obesity and other chronic illnesses demonstrate decrease in adherence to CVD pharmacotherapy.

Authors+Show Affiliations

Department of Pathophysiology, Medical University of Silesia, Katowice, Poland. chj@poczta.fmNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22801406

Citation

Chudek, J, et al. "Compliance in Pharmacotherapy in Patients With Chronic Venous Disorders." International Angiology : a Journal of the International Union of Angiology, vol. 31, no. 4, 2012, pp. 393-401.
Chudek J, Kocełak P, Ziaja D, et al. Compliance in pharmacotherapy in patients with chronic venous disorders. Int Angiol. 2012;31(4):393-401.
Chudek, J., Kocełak, P., Ziaja, D., Owczarek, A., & Ziaja, K. (2012). Compliance in pharmacotherapy in patients with chronic venous disorders. International Angiology : a Journal of the International Union of Angiology, 31(4), 393-401.
Chudek J, et al. Compliance in Pharmacotherapy in Patients With Chronic Venous Disorders. Int Angiol. 2012;31(4):393-401. PubMed PMID: 22801406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compliance in pharmacotherapy in patients with chronic venous disorders. AU - Chudek,J, AU - Kocełak,P, AU - Ziaja,D, AU - Owczarek,A, AU - Ziaja,K, PY - 2012/7/18/entrez PY - 2012/7/18/pubmed PY - 2012/12/10/medline SP - 393 EP - 401 JF - International angiology : a journal of the International Union of Angiology JO - Int Angiol VL - 31 IS - 4 N2 - AIM: The aim of this study was to evaluate the factors that limit the use of venoactive drugs (VADs), especially in patient with chronic venous disorders (CVD) noncompliant with compression therapy in a nationwide survey. METHODS: Analysis included 5134 CVD patients compliant with compression therapy and 4663 of those not accepting such method of therapy, participating in a large survey. RESULTS: Venoactive drugs (VADs) and topical agents were used significantly less frequently by patients noncompliant with compression therapy compared to the compliant population (95.2% vs. 97.7%, P<0.001 and 70.1% vs. 79.9%, P<0.001, respectively). There were also less patients on two VADs concurrently in these subgroups (14.6% vs. 24.6%, P<0.001 respectively). Logistic regression analysis confirmed that noncompliant also have decreased adherence to Ruscus aculeatus extracts (OR=0.870), micronized purified flavonoid fraction (MPFF) preparations (OR=0.886), and topical agents (OR=0.877), but not horse chestnuts seed extracts. Coexisting obesity and other chronic illnesses were among the factors that decreased the use of Ruscus aculeatus extracts and micronized purified flavonoid fraction (MPFF) preparations. The use of topical agents was reduced with age, male sex, patients with coexisting chronic illnesses, obesity and adverse to accepting compression therapy. Additionally diuretics, antiplatelet agents and low-molecular weight heparins were less frequently used in the noncompliant population. CONCLUSIONS: Patients who are not compliant with compression therapy are more frequently not adherent to pharmacological therapy. Coexisting obesity and other chronic illnesses demonstrate decrease in adherence to CVD pharmacotherapy. SN - 1827-1839 UR - https://www.unboundmedicine.com/medline/citation/22801406/Compliance_in_pharmacotherapy_in_patients_with_chronic_venous_disorders_ L2 - http://www.minervamedica.it/index2.t?show=R34Y2012N04A0393 DB - PRIME DP - Unbound Medicine ER -