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[Study on the correlation between Chinese medicine syndrome and the intestinal mucosal manifestations of 137 patients with active ulcerative colitis].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Apr; 32(4):445-9.ZZ

Abstract

OBJECTIVE

To observe the distribution features of Chinese medicine syndrome (CMS) in 137 patients with active ulcerative colitis (AUC), and to analyze the correlation between the intestinal mucosal manifestations and CMS.

METHODS

Totally 137 AUC patients were syndrome typed. The intestinal mucosal manifestations were observed under endoscope, thus analyzing the correlation between the intestinal mucosal manifestations and CMS.

RESULTS

In the distribution of main syndromes, the case numbers were sequenced as the damp heat of Dachang syndrome > the yang deficiency of Pi-Shen syndrome > the Gan-depression and Pi-deficiency syndrome > the deficiency of Pi-qi syndrome > the blood stasis of the intestine meridian syndrome > the deficiency of blood and yin syndrome. The frequency of intestinal mucosal manifestations more than 50% covered mucosal damage, abnormal mucosa membrane color, congestion, edema, erosion, ulcer, pus tongue fur, and obscure or disappeared blood vessels. The edema, erosion, and ulcer occurred more in the damp-heat of Dachang syndrome, followed by the yang deficiency of Pi-Shen syndrome and the Gan-depression and Pi-deficiency syndrome (P < 0.05, P < 0.01). Polypi, abnormal enterokinesia, grainy occurred more in the damp-heat of Dachang syndrome and the Gan-depression and Pi-deficiency syndrome (P = 0.010). Shallower plica or disappeared sacculations of colon occurred more in the yang deficiency of Pi-Shen syndrome and the damp-heat of Dachang syndrome (P = 0.002). The mucosa bridge occurred more in the yang deficiency of Pi-Shen syndrome and Gan-depression and Pi-deficiency syndrome (P = 0.280). Fragility or contact bleeding occurred more in the damp-heat of Dachang syndrome, the deficiency of Pi-qi syndrome, and Gan-depression and Pi-deficiency syndrome (P = 0. 045). Pale blood of the intestinal hemorrhage occurred more in the deficiency of Pi-qi syndrome while dark blood occurred more in the damp-heat of Dachang syndrome (P = 0.017). Pus tongue fur occurred more in the damp-heat of Dachang syndrome, the yang deficiency of Pi-Shen syndrome, and the Gan-depression and Pi-deficiency syndrome. White pus tongue fur occurred more in the yang deficiency of Pi-Shen syndrome while yellow pus tongue fur occurred more in the damp-heat of Dachang syndrome (P < 0.001). Mucus occurred more in the yang deficiency of Pi-Shen syndrome, the Gan-depression and Pi-deficiency syndrome, and the deficiency of Pi-qi syndrome (P = 0.012). Narrow enteric cavity or intestinal canal fibrosis, lead pipe like manifestations occurred more in the blood stasis of the intestine meridian syndrome (P = 0.001). Atrophic mucosa occurred more in the blood stasis of the intestine meridian syndrome and the deficiency of blood and yin syndrome (P < 0.001).

CONCLUSIONS

The intestinal mucosal manifestations of AUC showed certain laws in CMS. The microscopic differences could verify macroscopic CMS to some extent.

Authors+Show Affiliations

Department of Digestive Diseases, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

chi

PubMed ID

22803419

Citation

Wu, Jian, et al. "[Study On the Correlation Between Chinese Medicine Syndrome and the Intestinal Mucosal Manifestations of 137 Patients With Active Ulcerative Colitis]." Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, vol. 32, no. 4, 2012, pp. 445-9.
Wu J, Wang XY, Sun HY. [Study on the correlation between Chinese medicine syndrome and the intestinal mucosal manifestations of 137 patients with active ulcerative colitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32(4):445-9.
Wu, J., Wang, X. Y., & Sun, H. Y. (2012). [Study on the correlation between Chinese medicine syndrome and the intestinal mucosal manifestations of 137 patients with active ulcerative colitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, 32(4), 445-9.
Wu J, Wang XY, Sun HY. [Study On the Correlation Between Chinese Medicine Syndrome and the Intestinal Mucosal Manifestations of 137 Patients With Active Ulcerative Colitis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32(4):445-9. PubMed PMID: 22803419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the correlation between Chinese medicine syndrome and the intestinal mucosal manifestations of 137 patients with active ulcerative colitis]. AU - Wu,Jian, AU - Wang,Xin-Yue, AU - Sun,Hui-Yi, PY - 2012/7/19/entrez PY - 2012/7/19/pubmed PY - 2013/12/20/medline SP - 445 EP - 9 JF - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine JO - Zhongguo Zhong Xi Yi Jie He Za Zhi VL - 32 IS - 4 N2 - OBJECTIVE: To observe the distribution features of Chinese medicine syndrome (CMS) in 137 patients with active ulcerative colitis (AUC), and to analyze the correlation between the intestinal mucosal manifestations and CMS. METHODS: Totally 137 AUC patients were syndrome typed. The intestinal mucosal manifestations were observed under endoscope, thus analyzing the correlation between the intestinal mucosal manifestations and CMS. RESULTS: In the distribution of main syndromes, the case numbers were sequenced as the damp heat of Dachang syndrome > the yang deficiency of Pi-Shen syndrome > the Gan-depression and Pi-deficiency syndrome > the deficiency of Pi-qi syndrome > the blood stasis of the intestine meridian syndrome > the deficiency of blood and yin syndrome. The frequency of intestinal mucosal manifestations more than 50% covered mucosal damage, abnormal mucosa membrane color, congestion, edema, erosion, ulcer, pus tongue fur, and obscure or disappeared blood vessels. The edema, erosion, and ulcer occurred more in the damp-heat of Dachang syndrome, followed by the yang deficiency of Pi-Shen syndrome and the Gan-depression and Pi-deficiency syndrome (P < 0.05, P < 0.01). Polypi, abnormal enterokinesia, grainy occurred more in the damp-heat of Dachang syndrome and the Gan-depression and Pi-deficiency syndrome (P = 0.010). Shallower plica or disappeared sacculations of colon occurred more in the yang deficiency of Pi-Shen syndrome and the damp-heat of Dachang syndrome (P = 0.002). The mucosa bridge occurred more in the yang deficiency of Pi-Shen syndrome and Gan-depression and Pi-deficiency syndrome (P = 0.280). Fragility or contact bleeding occurred more in the damp-heat of Dachang syndrome, the deficiency of Pi-qi syndrome, and Gan-depression and Pi-deficiency syndrome (P = 0. 045). Pale blood of the intestinal hemorrhage occurred more in the deficiency of Pi-qi syndrome while dark blood occurred more in the damp-heat of Dachang syndrome (P = 0.017). Pus tongue fur occurred more in the damp-heat of Dachang syndrome, the yang deficiency of Pi-Shen syndrome, and the Gan-depression and Pi-deficiency syndrome. White pus tongue fur occurred more in the yang deficiency of Pi-Shen syndrome while yellow pus tongue fur occurred more in the damp-heat of Dachang syndrome (P < 0.001). Mucus occurred more in the yang deficiency of Pi-Shen syndrome, the Gan-depression and Pi-deficiency syndrome, and the deficiency of Pi-qi syndrome (P = 0.012). Narrow enteric cavity or intestinal canal fibrosis, lead pipe like manifestations occurred more in the blood stasis of the intestine meridian syndrome (P = 0.001). Atrophic mucosa occurred more in the blood stasis of the intestine meridian syndrome and the deficiency of blood and yin syndrome (P < 0.001). CONCLUSIONS: The intestinal mucosal manifestations of AUC showed certain laws in CMS. The microscopic differences could verify macroscopic CMS to some extent. SN - 1003-5370 UR - https://www.unboundmedicine.com/medline/citation/22803419/[Study_on_the_correlation_between_Chinese_medicine_syndrome_and_the_intestinal_mucosal_manifestations_of_137_patients_with_active_ulcerative_colitis]_ L2 - http://www.diseaseinfosearch.org/result/7285 DB - PRIME DP - Unbound Medicine ER -