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Evaluation of hydrophilic, hydrophobic and waxy matrix excipients for sustained release tablets of venlafaxine hydrochloride.
Drug Dev Ind Pharm. 2013 Aug; 39(8):1197-206.DD

Abstract

OBJECTIVE

Venlafaxine is freely soluble In water and administered orally as hydrochloride salt In two to three divided doses. In the present investigation different release retarding matrices have been evaluated for sustained release of venlafaxine hydrochloride (VH) from the formulated tablets.

MATERIALS AND METHODS

Sustained release matrix tablets were formulated using different hydrophilic, hydrophobic and waxy materials as matrix formers. Tableting was done by pre-compression, direct compression and hot melt granulation depending on the type of matrix material used and evaluated for different tests. The formulated tablets were compared with commercial venlafaxine products. In vitro drug dissolution profiles were fitted In different mathematical models to elucidate the release mechanism.

RESULTS

Dissolution data showed that commercial formulations Venlor XR(®) and Venfax PR(®) released the entire drug withIn 8 h where as the formulated tablets with hydroxypropylmethylcellulose (HPMC) and cetyl alcohol as matrix formers provided sustained release of drug for 14-15 h. The release was found to follow Hixson Crowel and Higuchi kinetics for HPMC and cetyl alcohol tablets, respectively.

CONCLUSION

The developed matrix tablet formulations with HPMC and cetyl alcohol provided sustained release profiles for prolonged periods than commercial formulations.

Authors+Show Affiliations

Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22803761

Citation

Yadav, Kiran, et al. "Evaluation of Hydrophilic, Hydrophobic and Waxy Matrix Excipients for Sustained Release Tablets of Venlafaxine Hydrochloride." Drug Development and Industrial Pharmacy, vol. 39, no. 8, 2013, pp. 1197-206.
Yadav K, Yadav D, Srivastava AK. Evaluation of hydrophilic, hydrophobic and waxy matrix excipients for sustained release tablets of venlafaxine hydrochloride. Drug Dev Ind Pharm. 2013;39(8):1197-206.
Yadav, K., Yadav, D., & Srivastava, A. K. (2013). Evaluation of hydrophilic, hydrophobic and waxy matrix excipients for sustained release tablets of venlafaxine hydrochloride. Drug Development and Industrial Pharmacy, 39(8), 1197-206. https://doi.org/10.3109/03639045.2012.704381
Yadav K, Yadav D, Srivastava AK. Evaluation of Hydrophilic, Hydrophobic and Waxy Matrix Excipients for Sustained Release Tablets of Venlafaxine Hydrochloride. Drug Dev Ind Pharm. 2013;39(8):1197-206. PubMed PMID: 22803761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of hydrophilic, hydrophobic and waxy matrix excipients for sustained release tablets of venlafaxine hydrochloride. AU - Yadav,Kiran, AU - Yadav,Deepak, AU - Srivastava,Anand Kumar, Y1 - 2012/07/17/ PY - 2012/7/19/entrez PY - 2012/7/19/pubmed PY - 2013/11/7/medline SP - 1197 EP - 206 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 39 IS - 8 N2 - OBJECTIVE: Venlafaxine is freely soluble In water and administered orally as hydrochloride salt In two to three divided doses. In the present investigation different release retarding matrices have been evaluated for sustained release of venlafaxine hydrochloride (VH) from the formulated tablets. MATERIALS AND METHODS: Sustained release matrix tablets were formulated using different hydrophilic, hydrophobic and waxy materials as matrix formers. Tableting was done by pre-compression, direct compression and hot melt granulation depending on the type of matrix material used and evaluated for different tests. The formulated tablets were compared with commercial venlafaxine products. In vitro drug dissolution profiles were fitted In different mathematical models to elucidate the release mechanism. RESULTS: Dissolution data showed that commercial formulations Venlor XR(®) and Venfax PR(®) released the entire drug withIn 8 h where as the formulated tablets with hydroxypropylmethylcellulose (HPMC) and cetyl alcohol as matrix formers provided sustained release of drug for 14-15 h. The release was found to follow Hixson Crowel and Higuchi kinetics for HPMC and cetyl alcohol tablets, respectively. CONCLUSION: The developed matrix tablet formulations with HPMC and cetyl alcohol provided sustained release profiles for prolonged periods than commercial formulations. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/22803761/Evaluation_of_hydrophilic_hydrophobic_and_waxy_matrix_excipients_for_sustained_release_tablets_of_venlafaxine_hydrochloride_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2012.704381 DB - PRIME DP - Unbound Medicine ER -