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MC1R variation and melanoma risk in relation to host/clinical and environmental factors in CDKN2A positive and negative melanoma patients.
Exp Dermatol 2012; 21(9):718-20ED

Abstract

Host, environmental and genetic factors differently modulate cutaneous melanoma (CM) risk across populations. Currently, the main genetic risk determinants are germline mutations in the major known high-risk susceptibility genes, CDKN2A and CDK4, and variants of the low-risk gene MC1R, which is key in the pigmentation process. This case-control study aimed at investigating the influence of the main host and environmental risk factors and of MC1R variation on CM risk in 390 CDKN2A-negative and 49 CDKN2A-positive Italian individuals. Multivariate analysis showed that MC1R variation, number of nevi and childhood sunburns doubled CM risk in CDKN2A-negative individuals. In CDKN2A-positive individuals, family history of CM and presence of atypical nevi, rather than MC1R status, modified risk (20.75- and 2.83-fold, respectively). Occupational sun exposure increased CM risk (three to sixfold) in both CDKN2A-negative and CDKN2A-positive individuals, reflecting the occupational habits of the Ligurian population and the geographical position of Liguria.

Authors+Show Affiliations

Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy. paola.ghiorzo@unige.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22804906

Citation

Ghiorzo, Paola, et al. "MC1R Variation and Melanoma Risk in Relation to Host/clinical and Environmental Factors in CDKN2A Positive and Negative Melanoma Patients." Experimental Dermatology, vol. 21, no. 9, 2012, pp. 718-20.
Ghiorzo P, Bonelli L, Pastorino L, et al. MC1R variation and melanoma risk in relation to host/clinical and environmental factors in CDKN2A positive and negative melanoma patients. Exp Dermatol. 2012;21(9):718-20.
Ghiorzo, P., Bonelli, L., Pastorino, L., Bruno, W., Barile, M., Andreotti, V., ... Queirolo, P. (2012). MC1R variation and melanoma risk in relation to host/clinical and environmental factors in CDKN2A positive and negative melanoma patients. Experimental Dermatology, 21(9), pp. 718-20. doi:10.1111/j.1600-0625.2012.01549.x.
Ghiorzo P, et al. MC1R Variation and Melanoma Risk in Relation to Host/clinical and Environmental Factors in CDKN2A Positive and Negative Melanoma Patients. Exp Dermatol. 2012;21(9):718-20. PubMed PMID: 22804906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MC1R variation and melanoma risk in relation to host/clinical and environmental factors in CDKN2A positive and negative melanoma patients. AU - Ghiorzo,Paola, AU - Bonelli,Luigina, AU - Pastorino,Lorenza, AU - Bruno,William, AU - Barile,Monica, AU - Andreotti,Virginia, AU - Nasti,Sabina, AU - Battistuzzi,Linda, AU - Grosso,Marco, AU - Bianchi-Scarrà,Giovanna, AU - Queirolo,Paola, PY - 2012/7/19/entrez PY - 2012/7/19/pubmed PY - 2013/3/6/medline SP - 718 EP - 20 JF - Experimental dermatology JO - Exp. Dermatol. VL - 21 IS - 9 N2 - Host, environmental and genetic factors differently modulate cutaneous melanoma (CM) risk across populations. Currently, the main genetic risk determinants are germline mutations in the major known high-risk susceptibility genes, CDKN2A and CDK4, and variants of the low-risk gene MC1R, which is key in the pigmentation process. This case-control study aimed at investigating the influence of the main host and environmental risk factors and of MC1R variation on CM risk in 390 CDKN2A-negative and 49 CDKN2A-positive Italian individuals. Multivariate analysis showed that MC1R variation, number of nevi and childhood sunburns doubled CM risk in CDKN2A-negative individuals. In CDKN2A-positive individuals, family history of CM and presence of atypical nevi, rather than MC1R status, modified risk (20.75- and 2.83-fold, respectively). Occupational sun exposure increased CM risk (three to sixfold) in both CDKN2A-negative and CDKN2A-positive individuals, reflecting the occupational habits of the Ligurian population and the geographical position of Liguria. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/22804906/MC1R_variation_and_melanoma_risk_in_relation_to_host/clinical_and_environmental_factors_in_CDKN2A_positive_and_negative_melanoma_patients_ L2 - https://doi.org/10.1111/j.1600-0625.2012.01549.x DB - PRIME DP - Unbound Medicine ER -