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Depressive symptoms are associated with (sub)clinical psychotic symptoms in patients with non-affective psychotic disorder, siblings and healthy controls.
Psychol Med. 2013 Apr; 43(4):747-56.PM

Abstract

BACKGROUND

Depression is a clinically relevant dimension, associated with both positive and negative symptoms, in patients with schizophrenia. However, in siblings it is unknown whether depression is associated with subclinical positive and negative symptoms. Method Depressive symptoms and their association with positive and negative symptoms were examined in 813 healthy siblings of patients with a non-affective psychotic disorder, 822 patients and 527 healthy controls. Depressive episodes meeting DSM-IV-TR criteria (lifetime) and depressed mood (lifetime) were assessed with the Comprehensive Assessment of Symptoms and History (CASH) in all three groups. In the patient group, the severity of positive and negative psychosis symptoms was assessed with the CASH. In the siblings and healthy controls, the severity of subclinical psychosis symptoms was assessed with the Community Assessment of Psychic Experiences (CAPE).

RESULTS

Patients reported more lifetime depressed mood and more depressive episodes than both siblings and controls. Siblings had a higher chance of meeting lifetime depressive episodes than the controls; no significant differences in depressed mood were found between siblings and controls. In all three groups the number and duration of depressive symptoms were associated with (sub)clinical negative symptoms. In the patients and siblings the number of depressive symptoms was furthermore associated with (sub)clinical positive symptoms. Finally, lifetime depressed mood showed familial clustering but this clustering was absent for lifetime depressive episodes.

CONCLUSIONS

These findings suggest that a co-occurring genetic vulnerability for both depressive and psychotic symptomatology exists on a clinical and a subclinical level.

Authors+Show Affiliations

Rivierduinen Mental Health, Leiden, The Netherlands. r.klaassen@ggzkinderenenjeugd.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22804999

Citation

Klaassen, R M C., et al. "Depressive Symptoms Are Associated With (sub)clinical Psychotic Symptoms in Patients With Non-affective Psychotic Disorder, Siblings and Healthy Controls." Psychological Medicine, vol. 43, no. 4, 2013, pp. 747-56.
Klaassen RM, Heins M, Luteijn LB, et al. Depressive symptoms are associated with (sub)clinical psychotic symptoms in patients with non-affective psychotic disorder, siblings and healthy controls. Psychol Med. 2013;43(4):747-56.
Klaassen, R. M., Heins, M., Luteijn, L. B., van der Gaag, M., & van Beveren, N. J. (2013). Depressive symptoms are associated with (sub)clinical psychotic symptoms in patients with non-affective psychotic disorder, siblings and healthy controls. Psychological Medicine, 43(4), 747-56. https://doi.org/10.1017/S0033291712001572
Klaassen RM, et al. Depressive Symptoms Are Associated With (sub)clinical Psychotic Symptoms in Patients With Non-affective Psychotic Disorder, Siblings and Healthy Controls. Psychol Med. 2013;43(4):747-56. PubMed PMID: 22804999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depressive symptoms are associated with (sub)clinical psychotic symptoms in patients with non-affective psychotic disorder, siblings and healthy controls. AU - Klaassen,R M C, AU - Heins,M, AU - Luteijn,L B, AU - van der Gaag,M, AU - van Beveren,N J M, AU - ,, Y1 - 2012/07/18/ PY - 2012/7/19/entrez PY - 2012/7/19/pubmed PY - 2013/9/21/medline SP - 747 EP - 56 JF - Psychological medicine JO - Psychol Med VL - 43 IS - 4 N2 - BACKGROUND: Depression is a clinically relevant dimension, associated with both positive and negative symptoms, in patients with schizophrenia. However, in siblings it is unknown whether depression is associated with subclinical positive and negative symptoms. Method Depressive symptoms and their association with positive and negative symptoms were examined in 813 healthy siblings of patients with a non-affective psychotic disorder, 822 patients and 527 healthy controls. Depressive episodes meeting DSM-IV-TR criteria (lifetime) and depressed mood (lifetime) were assessed with the Comprehensive Assessment of Symptoms and History (CASH) in all three groups. In the patient group, the severity of positive and negative psychosis symptoms was assessed with the CASH. In the siblings and healthy controls, the severity of subclinical psychosis symptoms was assessed with the Community Assessment of Psychic Experiences (CAPE). RESULTS: Patients reported more lifetime depressed mood and more depressive episodes than both siblings and controls. Siblings had a higher chance of meeting lifetime depressive episodes than the controls; no significant differences in depressed mood were found between siblings and controls. In all three groups the number and duration of depressive symptoms were associated with (sub)clinical negative symptoms. In the patients and siblings the number of depressive symptoms was furthermore associated with (sub)clinical positive symptoms. Finally, lifetime depressed mood showed familial clustering but this clustering was absent for lifetime depressive episodes. CONCLUSIONS: These findings suggest that a co-occurring genetic vulnerability for both depressive and psychotic symptomatology exists on a clinical and a subclinical level. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/22804999/Depressive_symptoms_are_associated_with__sub_clinical_psychotic_symptoms_in_patients_with_non_affective_psychotic_disorder_siblings_and_healthy_controls_ L2 - https://www.cambridge.org/core/product/identifier/S0033291712001572/type/journal_article DB - PRIME DP - Unbound Medicine ER -