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[Human papillomavirus infection in oropharyngeal squamous cell carcinoma and prognosis: a preliminary analysis of 66 cases].

Abstract

OBJECTIVE

To analyze the relationship between the prognosis of patients with oropharyngeal squamous cell carcinoma (OSCC) and human papillomavirus (HPV) infection in OSCC.

METHODS

Sixty-six patients with oropharyngeal carcinoma who met the enrollment criteria during the period from January 1999 to December 2009 were retrospectively reviewed. The presence or absence of HPV oncogenic types in OSCC specimen was determined by multiplex polymerase chain reaction (PCR). Overall survival (OS) and disease specific survival (DSS) for HPV-positive and HPV-negative patients were estimated by Kaplan-Meier analysis. Cox regression model was used for multivariate analysis.

RESULTS

HPV-DNA was detected in 11(16.7%) of all specimens. Among them, 7 were positive for HPV-16, 1 for HPV-16/11, 1 for HPV-35, 1 for HPV-58/52, and 1 for HPV-33/52/54. With the follow-up of 3-78 months (a median of 24.5 months), patients with HPV-positive tumors had significantly better overall survival (χ2=5.792, P=0.016) and disease specific survival (χ2=4.721, P=0.030), the 3-year OS and DSS were 90.0% vs 52.4% and 90.0% vs 56.4%, respectively. Multivariate analysis by Cox regression model showed that HPV infection and nodal status were both independent prognostic factors for patients with OSCC (P<0.05).

CONCLUSIONS

Patients with HPV-positive OSCC have significantly better prognosis than patients with HPV-negative tumors. HPV infection is an independent prognostic factor.

Authors+Show Affiliations

Department of Head and Neck Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

22805021

Citation

Huang, Hui, et al. "[Human Papillomavirus Infection in Oropharyngeal Squamous Cell Carcinoma and Prognosis: a Preliminary Analysis of 66 Cases]." Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery, vol. 47, no. 3, 2012, pp. 207-11.
Huang H, Zhang B, Chen W, et al. [Human papillomavirus infection in oropharyngeal squamous cell carcinoma and prognosis: a preliminary analysis of 66 cases]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012;47(3):207-11.
Huang, H., Zhang, B., Chen, W., Zhou, S. M., Zhang, Y. X., Gao, L., ... Tang, P. Z. (2012). [Human papillomavirus infection in oropharyngeal squamous cell carcinoma and prognosis: a preliminary analysis of 66 cases]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 47(3), pp. 207-11.
Huang H, et al. [Human Papillomavirus Infection in Oropharyngeal Squamous Cell Carcinoma and Prognosis: a Preliminary Analysis of 66 Cases]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012;47(3):207-11. PubMed PMID: 22805021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Human papillomavirus infection in oropharyngeal squamous cell carcinoma and prognosis: a preliminary analysis of 66 cases]. AU - Huang,Hui, AU - Zhang,Bin, AU - Chen,Wen, AU - Zhou,Shuang-mei, AU - Zhang,Yong-xia, AU - Gao,Li, AU - Xu,Zhen-gang, AU - Qiao,You-lin, AU - Tang,Ping-zhang, PY - 2012/7/19/entrez PY - 2012/7/19/pubmed PY - 2013/3/13/medline SP - 207 EP - 11 JF - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery JO - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi VL - 47 IS - 3 N2 - OBJECTIVE: To analyze the relationship between the prognosis of patients with oropharyngeal squamous cell carcinoma (OSCC) and human papillomavirus (HPV) infection in OSCC. METHODS: Sixty-six patients with oropharyngeal carcinoma who met the enrollment criteria during the period from January 1999 to December 2009 were retrospectively reviewed. The presence or absence of HPV oncogenic types in OSCC specimen was determined by multiplex polymerase chain reaction (PCR). Overall survival (OS) and disease specific survival (DSS) for HPV-positive and HPV-negative patients were estimated by Kaplan-Meier analysis. Cox regression model was used for multivariate analysis. RESULTS: HPV-DNA was detected in 11(16.7%) of all specimens. Among them, 7 were positive for HPV-16, 1 for HPV-16/11, 1 for HPV-35, 1 for HPV-58/52, and 1 for HPV-33/52/54. With the follow-up of 3-78 months (a median of 24.5 months), patients with HPV-positive tumors had significantly better overall survival (χ2=5.792, P=0.016) and disease specific survival (χ2=4.721, P=0.030), the 3-year OS and DSS were 90.0% vs 52.4% and 90.0% vs 56.4%, respectively. Multivariate analysis by Cox regression model showed that HPV infection and nodal status were both independent prognostic factors for patients with OSCC (P<0.05). CONCLUSIONS: Patients with HPV-positive OSCC have significantly better prognosis than patients with HPV-negative tumors. HPV infection is an independent prognostic factor. SN - 1673-0860 UR - https://www.unboundmedicine.com/medline/citation/22805021/[Human_papillomavirus_infection_in_oropharyngeal_squamous_cell_carcinoma_and_prognosis:_a_preliminary_analysis_of_66_cases]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1673-0860&amp;year=2012&amp;vol=47&amp;issue=3&amp;fpage=207 DB - PRIME DP - Unbound Medicine ER -