Tags

Type your tag names separated by a space and hit enter

Skin prick test and specific serum IgE in the diagnostic evaluation of suspected cow's milk and hen's egg allergy in children: does one replace the other?
Clin Exp Allergy 2012; 42(8):1266-72CE

Abstract

BACKGROUND

The measurement of specific serum immunoglobulin E (sIgE) and the skin prick test (SPT) are accepted tools in the diagnostic work-up of suspected food allergy. Often only one of the methods is used to determine sensitization; however, it is still under debate whether these two methods can be used interchangeably.

OBJECTIVES

To investigate the concordance of SPT and sIgE serum assays with regard to suspected food allergy.

METHODS

In 395 children referred to our clinic with suspected cow's milk allergy and in 268 children with suspected hen's egg allergy specific immunoglobulin E (IgE) was measured, a SPT and an oral food challenge performed. A weal size ≥ 3 mm and sIgE ≥ 0.35 kU/L were considered positive. The weal size of the SPT and the level of food-specific IgE were tested for correlation for each allergen.

RESULTS

Of the 395 (23%) children orally challenged with cow's milk, 92 showed no corresponding results for SPT and sIgE as either positive or negative. For hen's egg, in 27 of 268 (10%) children differing test results for SPT and sIgE in serum were obtained. Moreover, regarding the quantitative values for sIgE and SPT in children with or without clinically relevant food allergy, sIgE and SPT correlated badly.

CONCLUSIONS

The concordance between SPT and sIgE is surprisingly low for cow's milk and hen's egg on an individual basis. Therefore, the tests should not be used interchangeably. Especially in children who receive a negative test result the alternative test should also be used. Furthermore, our data indicate again that oral food challenges are still the method of choice to diagnose food allergies.

Authors+Show Affiliations

Department of Pediatric Pneumology and Immunology, Charité University Medical Center, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22805474

Citation

Mehl, A, et al. "Skin Prick Test and Specific Serum IgE in the Diagnostic Evaluation of Suspected Cow's Milk and Hen's Egg Allergy in Children: Does One Replace the Other?" Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 42, no. 8, 2012, pp. 1266-72.
Mehl A, Niggemann B, Keil T, et al. Skin prick test and specific serum IgE in the diagnostic evaluation of suspected cow's milk and hen's egg allergy in children: does one replace the other? Clin Exp Allergy. 2012;42(8):1266-72.
Mehl, A., Niggemann, B., Keil, T., Wahn, U., & Beyer, K. (2012). Skin prick test and specific serum IgE in the diagnostic evaluation of suspected cow's milk and hen's egg allergy in children: does one replace the other? Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 42(8), pp. 1266-72. doi:10.1111/j.1365-2222.2012.04046.x.
Mehl A, et al. Skin Prick Test and Specific Serum IgE in the Diagnostic Evaluation of Suspected Cow's Milk and Hen's Egg Allergy in Children: Does One Replace the Other. Clin Exp Allergy. 2012;42(8):1266-72. PubMed PMID: 22805474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Skin prick test and specific serum IgE in the diagnostic evaluation of suspected cow's milk and hen's egg allergy in children: does one replace the other? AU - Mehl,A, AU - Niggemann,B, AU - Keil,T, AU - Wahn,U, AU - Beyer,K, PY - 2012/7/19/entrez PY - 2012/7/19/pubmed PY - 2012/12/12/medline SP - 1266 EP - 72 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 42 IS - 8 N2 - BACKGROUND: The measurement of specific serum immunoglobulin E (sIgE) and the skin prick test (SPT) are accepted tools in the diagnostic work-up of suspected food allergy. Often only one of the methods is used to determine sensitization; however, it is still under debate whether these two methods can be used interchangeably. OBJECTIVES: To investigate the concordance of SPT and sIgE serum assays with regard to suspected food allergy. METHODS: In 395 children referred to our clinic with suspected cow's milk allergy and in 268 children with suspected hen's egg allergy specific immunoglobulin E (IgE) was measured, a SPT and an oral food challenge performed. A weal size ≥ 3 mm and sIgE ≥ 0.35 kU/L were considered positive. The weal size of the SPT and the level of food-specific IgE were tested for correlation for each allergen. RESULTS: Of the 395 (23%) children orally challenged with cow's milk, 92 showed no corresponding results for SPT and sIgE as either positive or negative. For hen's egg, in 27 of 268 (10%) children differing test results for SPT and sIgE in serum were obtained. Moreover, regarding the quantitative values for sIgE and SPT in children with or without clinically relevant food allergy, sIgE and SPT correlated badly. CONCLUSIONS: The concordance between SPT and sIgE is surprisingly low for cow's milk and hen's egg on an individual basis. Therefore, the tests should not be used interchangeably. Especially in children who receive a negative test result the alternative test should also be used. Furthermore, our data indicate again that oral food challenges are still the method of choice to diagnose food allergies. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/22805474/Skin_prick_test_and_specific_serum_IgE_in_the_diagnostic_evaluation_of_suspected_cow's_milk_and_hen's_egg_allergy_in_children:_does_one_replace_the_other L2 - https://doi.org/10.1111/j.1365-2222.2012.04046.x DB - PRIME DP - Unbound Medicine ER -