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Statin use and risk of breast cancer: a meta-analysis of observational studies.
Breast Cancer Res Treat. 2012 Aug; 135(1):261-9.BC

Abstract

Emerging evidence suggests that statins' may decrease the risk of cancers. However, available evidence on breast cancer is conflicting. We, therefore, examined the association between statin use and risk of breast cancer by conducting a detailed meta-analysis of all observational studies published regarding this subject. PubMed database and bibliographies of retrieved articles were searched for epidemiological studies published up to January 2012, investigating the relationship between statin use and breast cancer. Before meta-analysis, the studies were evaluated for publication bias and heterogeneity. Combined relative risk (RR) and 95 % confidence interval (CI) were calculated using a random-effects model (DerSimonian and Laird method). Subgroup analyses, sensitivity analysis, and cumulative meta-analysis were also performed. A total of 24 (13 cohort and 11 case-control) studies involving more than 2.4 million participants, including 76,759 breast cancer cases contributed to this analysis. We found no evidence of publication bias and evidence of heterogeneity among the studies. Statin use and long-term statin use did not significantly affect breast cancer risk (RR = 0.99, 95 % CI = 0.94, 1.04 and RR = 1.03, 95 % CI = 0.96, 1.11, respectively). When the analysis was stratified into subgroups, there was no evidence that study design substantially influenced the effect estimate. Sensitivity analysis confirmed the stability of our results. Cumulative meta-analysis showed a change in trend of reporting risk of breast cancer from positive to negative in statin users between 1993 and 2011. Our meta-analysis findings do not support the hypothesis that statins' have a protective effect against breast cancer. More randomized clinical trials and observational studies are needed to confirm this association with underlying biological mechanisms in the future.

Authors+Show Affiliations

Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab, India. krishna.niperian10@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

22806241

Citation

Undela, Krishna, et al. "Statin Use and Risk of Breast Cancer: a Meta-analysis of Observational Studies." Breast Cancer Research and Treatment, vol. 135, no. 1, 2012, pp. 261-9.
Undela K, Srikanth V, Bansal D. Statin use and risk of breast cancer: a meta-analysis of observational studies. Breast Cancer Res Treat. 2012;135(1):261-9.
Undela, K., Srikanth, V., & Bansal, D. (2012). Statin use and risk of breast cancer: a meta-analysis of observational studies. Breast Cancer Research and Treatment, 135(1), 261-9. https://doi.org/10.1007/s10549-012-2154-x
Undela K, Srikanth V, Bansal D. Statin Use and Risk of Breast Cancer: a Meta-analysis of Observational Studies. Breast Cancer Res Treat. 2012;135(1):261-9. PubMed PMID: 22806241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin use and risk of breast cancer: a meta-analysis of observational studies. AU - Undela,Krishna, AU - Srikanth,Vallakatla, AU - Bansal,Dipika, Y1 - 2012/07/18/ PY - 2012/02/13/received PY - 2012/06/25/accepted PY - 2012/7/19/entrez PY - 2012/7/19/pubmed PY - 2013/1/25/medline SP - 261 EP - 9 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 135 IS - 1 N2 - Emerging evidence suggests that statins' may decrease the risk of cancers. However, available evidence on breast cancer is conflicting. We, therefore, examined the association between statin use and risk of breast cancer by conducting a detailed meta-analysis of all observational studies published regarding this subject. PubMed database and bibliographies of retrieved articles were searched for epidemiological studies published up to January 2012, investigating the relationship between statin use and breast cancer. Before meta-analysis, the studies were evaluated for publication bias and heterogeneity. Combined relative risk (RR) and 95 % confidence interval (CI) were calculated using a random-effects model (DerSimonian and Laird method). Subgroup analyses, sensitivity analysis, and cumulative meta-analysis were also performed. A total of 24 (13 cohort and 11 case-control) studies involving more than 2.4 million participants, including 76,759 breast cancer cases contributed to this analysis. We found no evidence of publication bias and evidence of heterogeneity among the studies. Statin use and long-term statin use did not significantly affect breast cancer risk (RR = 0.99, 95 % CI = 0.94, 1.04 and RR = 1.03, 95 % CI = 0.96, 1.11, respectively). When the analysis was stratified into subgroups, there was no evidence that study design substantially influenced the effect estimate. Sensitivity analysis confirmed the stability of our results. Cumulative meta-analysis showed a change in trend of reporting risk of breast cancer from positive to negative in statin users between 1993 and 2011. Our meta-analysis findings do not support the hypothesis that statins' have a protective effect against breast cancer. More randomized clinical trials and observational studies are needed to confirm this association with underlying biological mechanisms in the future. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/22806241/Statin_use_and_risk_of_breast_cancer:_a_meta_analysis_of_observational_studies_ L2 - https://doi.org/10.1007/s10549-012-2154-x DB - PRIME DP - Unbound Medicine ER -