Citation
Dechet, Amy M., et al. "Leptospirosis Outbreak Following Severe Flooding: a Rapid Assessment and Mass Prophylaxis Campaign; Guyana, January-February 2005." PloS One, vol. 7, no. 7, 2012, pp. e39672.
Dechet AM, Parsons M, Rambaran M, et al. Leptospirosis outbreak following severe flooding: a rapid assessment and mass prophylaxis campaign; Guyana, January-February 2005. PLoS One. 2012;7(7):e39672.
Dechet, A. M., Parsons, M., Rambaran, M., Mohamed-Rambaran, P., Florendo-Cumbermack, A., Persaud, S., Baboolal, S., Ari, M. D., Shadomy, S. V., Zaki, S. R., Paddock, C. D., Clark, T. A., Harris, L., Lyon, D., & Mintz, E. D. (2012). Leptospirosis outbreak following severe flooding: a rapid assessment and mass prophylaxis campaign; Guyana, January-February 2005. PloS One, 7(7), e39672. https://doi.org/10.1371/journal.pone.0039672
Dechet AM, et al. Leptospirosis Outbreak Following Severe Flooding: a Rapid Assessment and Mass Prophylaxis Campaign; Guyana, January-February 2005. PLoS One. 2012;7(7):e39672. PubMed PMID: 22808049.
TY - JOUR
T1 - Leptospirosis outbreak following severe flooding: a rapid assessment and mass prophylaxis campaign; Guyana, January-February 2005.
AU - Dechet,Amy M,
AU - Parsons,Michele,
AU - Rambaran,Madan,
AU - Mohamed-Rambaran,Pheona,
AU - Florendo-Cumbermack,Anita,
AU - Persaud,Shamdeo,
AU - Baboolal,Shirematee,
AU - Ari,Mary D,
AU - Shadomy,Sean V,
AU - Zaki,Sherif R,
AU - Paddock,Christopher D,
AU - Clark,Thomas A,
AU - Harris,Lazenia,
AU - Lyon,Douglas,
AU - Mintz,Eric D,
Y1 - 2012/07/09/
PY - 2011/07/02/received
PY - 2012/05/25/accepted
PY - 2012/7/19/entrez
PY - 2012/7/19/pubmed
PY - 2013/3/27/medline
SP - e39672
EP - e39672
JF - PloS one
JO - PLoS One
VL - 7
IS - 7
N2 - BACKGROUND: Leptospirosis is a zoonosis usually transmitted through contact with water or soil contaminated with urine from infected animals. Severe flooding can put individuals at greater risk for contracting leptospirosis in endemic areas. Rapid testing for the disease and large-scale interventions are necessary to identify and control infection. We describe a leptospirosis outbreak following severe flooding and a mass chemoprophylaxis campaign in Guyana. METHODOLOGY/PRINCIPAL FINDINGS: From January-March 2005, we collected data on suspected leptospirosis hospitalizations and deaths. Laboratory testing included anti-leptospiral dot enzyme immunoassay (DST), immunohistochemistry (IHC) staining, and microscopic agglutination testing (MAT). DST testing was conducted for 105 (44%) of 236 patients; 52 (50%) tested positive. Four (57%) paired serum samples tested by MAT were confirmed leptospirosis. Of 34 total deaths attributed to leptospirosis, postmortem samples from 10 (83%) of 12 patients were positive by IHC. Of 201 patients interviewed, 89% reported direct contact with flood waters. A 3-week doxycycline chemoprophylaxis campaign reached over 280,000 people. CONCLUSIONS: A confirmed leptospirosis outbreak in Guyana occurred after severe flooding, resulting in a massive chemoprophylaxis campaign to try to limit morbidity and mortality.
SN - 1932-6203
UR - https://www.unboundmedicine.com/medline/citation/22808049/Leptospirosis_outbreak_following_severe_flooding:_a_rapid_assessment_and_mass_prophylaxis_campaign
L2 - https://dx.plos.org/10.1371/journal.pone.0039672
DB - PRIME
DP - Unbound Medicine
ER -