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[Presence of IgG class antibodies anti-measles virus in sera of subjects in different age].
Med Dosw Mikrobiol. 2012; 64(1):73-8.MD

Abstract

INTRODUCTION

The increase of measles incidence in Poland was recently observed. Furthermore, the analysis of routine serological tests performed in the department of virology, NIPH-NIH revealed, that nearly half of young people (20-30 years old) have no antibodies against measles virus. The paper presents results of IgG specific for measles virus prevalence in the sera of vaccinated and unvaccinated subjects, which aimed to make the selection of groups for immunological memory research.

METHODS

Total of 100 persons were examined based on results of determination of the presence of IgG anti-MeV: 26 people born before and 74 born after 1972 year. From this group, 55 participants were selected for further study and divided into 3 groups (1) subjects born before 1972, unvaccinated against measles and seropositive as a result of natural infection, (2) subjects born after 1972, vaccinated against measles but seronegative or with traces ofanti-MeV IgG presence, (3) subjects born after 1972 seropositive due to vaccination. Selected persons are subject to further examinations include determination the number of leukocytes and lymphocytes profile.

RESULTS

The level of anty-MeV IgG antibodies in subjects after natural infection was significantly higher compared to levels obtained by vaccinations. No significant differences in the immunological parameters which could influence on immune response were observed.

CONCLUSIONS

Obtained results lead to search other factors that may affect the weak postvaccinal humoral response.

Authors+Show Affiliations

Cześcik A
Zakład Wirusologii NIZP-PZH w Warszawie.
Dunal M
No affiliation info available
Trzcińska A
No affiliation info available
Siennicka J
No affiliation info available

MeSH

AdultAntibodies, Anti-IdiotypicAntibodies, ViralFemaleHumansImmunity, HumoralImmunoglobulin GMaleMeaslesMeasles VaccineMeasles virusSeroepidemiologic StudiesSerologic TestsYoung Adult

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

22808732

Citation

Cześcik, Agnieszka, et al. "[Presence of IgG Class Antibodies Anti-measles Virus in Sera of Subjects in Different Age]." Medycyna Doswiadczalna I Mikrobiologia, vol. 64, no. 1, 2012, pp. 73-8.
Cześcik A, Dunal M, Trzcińska A, et al. [Presence of IgG class antibodies anti-measles virus in sera of subjects in different age]. Med Dosw Mikrobiol. 2012;64(1):73-8.
Cześcik, A., Dunal, M., Trzcińska, A., & Siennicka, J. (2012). [Presence of IgG class antibodies anti-measles virus in sera of subjects in different age]. Medycyna Doswiadczalna I Mikrobiologia, 64(1), 73-8.
Cześcik A, et al. [Presence of IgG Class Antibodies Anti-measles Virus in Sera of Subjects in Different Age]. Med Dosw Mikrobiol. 2012;64(1):73-8. PubMed PMID: 22808732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Presence of IgG class antibodies anti-measles virus in sera of subjects in different age]. AU - Cześcik,Agnieszka, AU - Dunal,Milena, AU - Trzcińska,Agnieszka, AU - Siennicka,Joanna, PY - 2012/7/20/entrez PY - 2012/7/20/pubmed PY - 2012/8/10/medline SP - 73 EP - 8 JF - Medycyna doswiadczalna i mikrobiologia JO - Med Dosw Mikrobiol VL - 64 IS - 1 N2 - INTRODUCTION: The increase of measles incidence in Poland was recently observed. Furthermore, the analysis of routine serological tests performed in the department of virology, NIPH-NIH revealed, that nearly half of young people (20-30 years old) have no antibodies against measles virus. The paper presents results of IgG specific for measles virus prevalence in the sera of vaccinated and unvaccinated subjects, which aimed to make the selection of groups for immunological memory research. METHODS: Total of 100 persons were examined based on results of determination of the presence of IgG anti-MeV: 26 people born before and 74 born after 1972 year. From this group, 55 participants were selected for further study and divided into 3 groups (1) subjects born before 1972, unvaccinated against measles and seropositive as a result of natural infection, (2) subjects born after 1972, vaccinated against measles but seronegative or with traces ofanti-MeV IgG presence, (3) subjects born after 1972 seropositive due to vaccination. Selected persons are subject to further examinations include determination the number of leukocytes and lymphocytes profile. RESULTS: The level of anty-MeV IgG antibodies in subjects after natural infection was significantly higher compared to levels obtained by vaccinations. No significant differences in the immunological parameters which could influence on immune response were observed. CONCLUSIONS: Obtained results lead to search other factors that may affect the weak postvaccinal humoral response. SN - 0025-8601 UR - https://www.unboundmedicine.com/medline/citation/22808732/[Presence_of_IgG_class_antibodies_anti_measles_virus_in_sera_of_subjects_in_different_age]_ DB - PRIME DP - Unbound Medicine ER -